Instructor, Department of Pediatrics (Infectious Diseases)
Dr. Mesquita is a virologist with extensive experience in HIV and STI prevention. His research focuses on developing and optimizing in vitro and ex vivo models to evaluate drug safety and efficacy. He developed a dual-chamber model system to explore the safety of microbicides by examining their impact on the epithelial barrier. This model has proven predictive of microbicide safety, was recently adopted by the NIH as part of their recommended safety algorithm and will be available through the NIH Contract Office to evaluate new microbicides. In addition, Dr. Mesquita adapted this dual-chamber model to evaluate the ability of microbicides to traverse the epithelial barrier (bioavailability) and developed a novel co-culture method to assess drug pharmacodynamics in cervical and vaginal tissue samples from human and non-human origin (rabbit, sheep and non-human primates) ex vivo.
Fletcher PS, Wallace GS, Mesquita PMM, Shattock RJ. Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. Retrovirology. 2006 Aug 1;3:46.
Madan RP*, Mesquita PMM*, Cheshenko N, Jing B, Shende V, Guzman E, Heald T, Keller MJ, Regen SL, Shattock RJ, Herold BC. Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infections. J Virol. 2007 Jul;81(14):7636-46. Epub 2007 May 9. * authors contributed equally
Mesquita PMM, Wilson SS, Manlow P, Fischetti L, Keller MJ, Herold BC, Shattock RJ. Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. J Virol. 2008 Jul;82(13):6576-84. Epub 2008 Apr 23.
Fakioglu E, Wilson SS, Mesquita PMM, Hazrati E, Cheshenko N, Blaho JA, Herold BC. Herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion mechanism. J Virol. 2008 Oct;82(19):9337-44. Epub 2008 Jul 30.
Mesquita PMM, Cheshenko N, Wilson SS, Mhatre M, Guzman E, Fakioglu E, Keller MJ, Herold BC. Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. J Infect Dis. 2009 Aug 15;200(4):599-608.
Wilson SS, Cheshenko N, Fakioglu E, Mesquita PMM, Keller MJ, Herold BC. Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety. Antivir Ther. 2009;14(8):1113-24.
Keller MJ, Mesquita PMM, Torres NM, Cho S, Shust G, Madan RP, Cohen HW, Petrie J, Ford T, Soto-Torres L, Profy AT, Herold BC. Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials. PLoS One. 2010 Jan 22;5(1):e8781.
Herold BC, Mesquita PMM, Madan RP, Keller MJ. Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections. Am J Reprod Immunol. 2011 Mar;65(3):325-33. doi: 10.1111/j.1600-0897.2010.00932.x. Epub 2010 Dec 12. Review.
Keller MJ, Madan RP, Torres NM, Fazzari MJ, Cho S, Kalyoussef S, Shust G, Mesquita PMM, Louissaint N, Chen J, Cohen HW, Diament EC, Lee AC, Soto-Torres L, Hendrix CW, Herold BC. A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel. PLoS One. 2011 Jan 25;6(1):e16475.
Segarra TJ, Fakioglu E, Cheshenko N, Wilson SS, Mesquita PMM, Doncel GF, Herold BC. Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety. PLoS One. 2011;6(11):e27675. Epub 2011 Nov 11.
Mesquita PMM*, Rastogi R*, Segarra TJ, Teller RS, Torres NM, Huber AM, Kiser PF, Herold BC. Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and HSV infection. J Antimicrob Chemother 2012, 67(7): 1730-1738 first published online March 30, 2012 doi:10.1093/jac/dks097. * authors contributed equally.
Kiser, PF, Mesquita, PMM, Herold BC. A perspective on knowledge and gaps in HIV prevention science. AIDS Research amd Human Retroviruses, in press
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