Faculty Profile

Dr. Kartik Chandran, Ph.D.

Kartik Chandran, Ph.D.

Professor, Department of Microbiology & Immunology

Harold and Muriel Block Faculty Scholar in Virology

Areas of Research: Emerging viruses; Ebola and Marburg viruses; bunyaviruses; hantaviruses; viral entry into cells; structure and function of viral fusion glycoproteins; virus-host interactions; viral genetics; antivirals

Professional Interests

Basic and Translational Research on Emerging RNA Viruses 

As our world grows more interconnected and humans impinge on the few remaining wild habitats, infections caused by the accidental transmission of viruses from their natural animal hosts to humans are increasingly of concern. The unprecedented 2013–2015 Ebola virus disease epidemic in western Africa provides a particularly apt example. Few specific antiviral treatments are available for Ebola and other emerging agents, and our ability to develop them is challenged by a poor understanding of exactly how viruses co-opt our own cells at the molecular level.

The Chandran Lab at Einstein strives to understand this molecular warfare between virus and cell, and to apply what we learn to the development of antiviral treatments. Filoviruses, such as Ebola virus and Marburg virus, and hantaviruses, such as Sin Nombre virus and Hantaan virus, are major topics of study in our group. Working collaboratively with our partners on three continents, we have helped uncover critical host factors required for cell invasion by Ebola virus, including the long-sought viral receptor, Niemann-Pick C1 (NPC1). One of our recent interests is to decipher how genetic variation in host-encoded factors—in NPC1, for example—can influence the susceptibility of humans and animals to viral infection and the likelihood of animal-to-human 'host-jumping' events. Our ongoing efforts also include translational studies to develop anti-Ebola drugs, including small molecule and antibody therapeutics, targeting host factors critical for viral invasion.

Selected Publications

Please go here for complete bibliography.

More Information About Dr. Kartik Chandran

Chandran Lab website

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 403
Bronx, NY 10461

Tel: 718.430.8852

Research Information

Media Coverage

Wall Street Journal interviews Drs. Kartik Chandran and Steven Walkley about the connection between the rare genetic disease Niemann-Pick Type C and Ebola. (subscription)

The New York Daily News interviews Dr. Kartik Chandran about the evolving Ebola epidemic and the risk of airline travel.

More media coverage