Assistant Professor, Department of Radiation Oncology
Macrophages in Intestinal stem cell regeneration.
Intestinal epithelial homeostasis depends upon the signaling crosstalk between the crypt intestinal stem cells (ISC) and the surrounding niche including the intestinal subepithelial myofibroblasts, endothelial cells and the macrophages. Our studies in radiation injury model have indicated that macrophages plays a pivotal role in intestinal regeneration.We are using novel mouse genetic and virus based tools to determine macrophage derived regenerative signals and their role in ISC self renewal and proliferation. Identification of macrophage derived regenerative signals will allow us to develop novel therapeutic approaches against intstinal injury.
Unfolded Protein Response and chemoresistant tumor
Role of unfolded protein response in high intensity focused ultrasound (HIFU) treated tumor cells to induce endoplasmic reticular stress and cell death in chemo-resistant tumors. This would allow therapeutic ultrasound to be a chemosensitizer for the treatment of recurrent and resistant solid tumors.
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Albert Einstein College of Medicine
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