Samuel Zeav Soffer, M.D.

Soffer SZ , Huang J, Kim E, McCrudden KW, Huang J, New T, Manley CA, O’Toole K, Yamashiro D, Kandel JJ. Vascular remodeling marks tumors that recur during chronic VEGF blockade. Molecular Cancer Research, 2:36-42, 2004 Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'Toole K, Yamashiro DJ, Kandel JJ. Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/ neu-expressing experimental Wilms tumor. J Pediatr Surg, 38(11): 1569-1573, 2003 Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'Toole K, Yamashiro DJ, Kandel JJ. Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncol Rep., 10(5): 1271-4, 2003 Kim E, Serur A, Huang J, Manley C, McCrudden K, Frischer J, Soffer SZ, Ring L, New T, Zabski S, Rudge J, Holash J, Yancopoulos G, Kandel JJ, and Yamashiro DJ. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. PNAS, 99(17): 11399-11404, 2002 Soffer SZ, Kim E, Huang J, Moore JT, McCrudden K, Yokoi A, Manley C, O’Toole K, Middlesworth W, Stolar C, Yamshiro DJ, Kandel JJ. Resistance of a VEGF-producing tumor to anti-VEGF antibody: unimpeded growth of human rhabdoid tumor xenografts. J Pediatr Surg, 37(3): 528-32, 2002 Mcnelis J, Soffer SZ, Marini C, Jurkiewicz A, Ritter G, Simms HH, Nathan I. Abdominal compartment syndrome in the surgical intensive care unit. American Surgeon, 68: 18-23, 2002 Kim ES, Soffer SZ, Huang J, Moore JT, McCrudden K, Yokoi A, Manley C, O’Toole K, Stolar CJ, Kandel JJ, Yamashiro DJ. Distinct response of experimental neuroblastoma to combination anti-angiogenic strategies. J Pediatr Surg, 37(3): 518-22, 2002 Huang J, Soffer SZ, Kim E, Yokoi A, Moore JT, Manley C, O’Toole K, Stolar C, Yamashiro DJ, Kandel JJ. P53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease. J Pediatr Surg, 37(3): 523-27, 2002 Rosen NG, Hong AR, Soffer SZ, Rodriguez G, Peña A. Recto-vaginal fistula: A common diagnostic error with significant consequences in female patients with anorectal malformations. J Pediatr Surg, 37(7): 961-5, 2002 McCrudden KW, Yokoi A, Thosani A, Soffer SZ, Kim ES, Huang J, Manley C, O’Toole K, Yamashiro, DJ, Kandel JJ, Middlesworth W. Topotecan is anti-angiogenic in experimental hepatoblastoma, J Pediatr Surg, 37(6): 857-61, 2002 Soffer SZ, Moore J, Huang J, Kim E, Manley C, O'Toole K, Stolar C, Yamashiro D, Kandel J. Novel use of an established agent: topotecan is anti-angiogenic in experimental Wilms tumor. J Pediatr Surg, 36(12): 1781-84, 2001 Soffer SZ, Moore J, Kim E, Huang J, O’Toole, K, Stolar C, Yamashiro D, Kandel J. Combination anti-angiogenic therapy: increased efficacy in a murine model of Wilms tumor. J Pediatr Surg, 36(8): 1177-81, 2001 Moore J, Lee M, Garzon M, Soffer S, Kim E, Saouaf R, Toro G, Yamashiro D, Kandel J. Effective therapy of a vascular tumor of infancy with vincristine. J Pediatr Surg, 36(8): 1273-6, 2001 Kim E, Moore J, Huang J, Soffer S, Manley C, O'Toole K, Stolar CJ, Kandel JJ, Yamashiro DJ. All angiogenesis is not the same: distinct patterns of response to anti-angiogenic therapy in experimental neuroblastoma and Wilms tumor. J Pediatr Surg, 36(2): 287-90, 2001 Huang J, Moore J, Soffer S, Kim E, Rowe D, Manley C, O'Toole K, Stolar C, Yamashiro D, Kandel J. Highly specific anti-angiogenic therapy is effective in suppressing growth of experimental Wilms tumor. J Pediatr Surg, 36(2): 357-61, 2001 Rosen N, Gibbs D, Soffer SZ, Valderama E, Lee T. Uroepithelium in a colonic diverticulum. J Pediatr Surg, 35(9): 1375-6, 2000 Soffer SZ, Rosen N, Hong A, Alexianu M, Peña A. Cloacal exstrophy: a unified management plan. J Pediatr Surg, 35: 932-7, 2000 Rosen N, Gibbs D, Sher M, Soffer SZ, Peña A. Non-operative management of fistula-in-ano. J Pediatr Surg, 35: 938-9, 2000 Levitt MA, Soffer SZ, Peña A. Continent appendicostomy in the bowel management of fecally incontinent children. J Pediatr Surg, 32:11, 1997 Published Abstracts Kim E, Soffer S, Huang J, Manley C, McCrudden K, Moore J, Stolar C, Holash J, Yancopoulos G, Kandel J, Yamashiro D. Vascular cooption in neuroblastoma: a potential mechanism of resistance to anti-angiogenesis. Surgical Forum Volume, 2001 Kim E, Huang J, Wu N, Manley CA, Rowe DH, Soffer SZ, Moore JT, O'Toole KM, Stolar CJ, Kandel JJ, Yamashiro DJ. Anti-VEGF antibody inhibits primary tumor growth in a metastatic model of neuroblastoma (NBL). Med Pediatr Oncol, 35:6:755, 2000. Yamashiro DJ, Huang J, Manley CA, Kim E, Soffer SZ, Moore JT, Wu N, Rowe DH, Hagani AB, O'Toole KM, Stolar CJ, Kandel JJ. A new in vivo metastatic model of neuroblastoma. Med Pediatr Oncol, 35:6:755, 2000 Soffer SZ, Rosen N, Hong A, Alexianu M, Peña A. Cloacal exstrophy: a unified management plan. Pediatrics, 104(3 Supplement): 776, 1999 Rosen N, Gibbs D, Sher M, Soffer SZ, Peña A. Non-operative management of fistula-in-ano. Pediatrics, 104(3 Supplement): 776, 1999 Soffer SZ, Kiffel YS, Gillette PN, Kral JG. Nutritional effects of sickle cell disease: a study of body mass index. J American College of Nutrition, 15:5,1996