Faculty Profile

Dr. Srikanta Ghosh, Ph.D.

Srikanta Ghosh, Ph.D.

Associate, Department of Cell Biology

Professional Interests

During development of a multicellular organism cells proliferate for a defined length of time before they begin functional differentiation. Precise regulation of proliferation and differentiation is needed to ensure proper development. Studies in different cell types have shown that these two processed are tightly coordinated during normal development. The hallmark features of tumor cells are that they have developed a block to normal differentiation and gained unlimited proliferative capacity. Thus understanding the molecular mechanism of cross-talk between cell proliferation and differentiation in important. Proliferation of mammalian cells is primarily governed by the activities of a family of serine/threonine - proline kinases called cyclin-dependent kinases(CDKs), while differentiation is believed to be controlled by lineage specific transcription factors. The decision to proliferate or differentiate is made in the G1 phase of the cell cycle. Using murine erythroleukemia (MEL) cells we have found that a G1 specific kinase CDK6 can block the differentiation of MEL cells to red blood cells. The phenomenom is very specific to CDK6 as another G1 specific CDKs, CDK4, cannot mediate this block. Moreover we have found that the kinase activity of CDK6 is required to mediate this block in differentiation. Thus CDK6 is blocking differentiation by phosphorylating a novel substance. Thus the goal of my research is to identify novel substrates of CDK6 and elucidate the mechanism of CDK6 mediated block in differentiation. I am utilizing proteomics, chemical genetics and cell biological methods to identify those novel substrates.

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Chanin Building, Room 402
Bronx, NY 10461

Tel: 718.430.2168
Fax: 718.430.8574
srikanta.ghosh@einstein.yu.edu

Research Information