Faculty Profile

Dr. Masako Suzuki, Ph.D., D.V.M.

Masako Suzuki, Ph.D., D.V.M.

Research Assistant Professor, Department of Genetics

Professional Interests

Background: I am an epigenetics researcher who has formally trained in Clinical and Translational Research method with broad knowledge of basic biology, assay development and bioinformatics. 

My original degree was an Animal Physiology and Biochemistry doctorate in basic veterinary medicine under the supervision of Dr. Bunei Syuto at United Graduate School of Veterinary Sciences of Gifu University in Japan.  As a postdoctoral fellow at the University of Tokyo under the supervision of Dr. Kunio Shiota, I started to expand my research into epigenetic regulation and carried out tissue and cell-specific genome-wide DNA methylation profiling using restriction enzyme landmark genome scanning (RLGS) as well as developing novel techniques to analyze tissue-specific DNA methylation profiles in animal models.  After I moved to the US, I worked to develop new epigenome-wide assays and, critically, gained bioinformatic expertise so that I could perform effective analyses on the data generated.  I consequently started working with many clinical and translational researchers at the Albert Einstein College of Medicine.  These experiences prompted me to expand my research interest from basic biology research to a greater emphasis on translational research.  In 2012, I was awarded a Career Development Award sponsored by a Clinical and Translational Science Award (CTSA) from NIH and the Einstein-Montefiore Institute for Clinical and Translational Research.  Moreover, to obtain formal didactic training in clinical research methods, I performed further graduate studies, recently graduating from the Masters course (2 year Clinical Research Training Program) at the Einstein Institute of Clinical and Translational Research. 

Current project: My research goals are focused on understanding the relationship between epigenetic alterations and human diseases, especially finding alteration susceptible regions for gaining the information for future preventative intervention.

Selected Publications

Selected publications (from 49 publications)

  1. Suzuki M, Jing Q, Lia D, Pascual M, McLellan A, Greally JM. Optimized design and data analysis of tag-based cytosine methylation assays. Genome Biol. 2010;11(4):R36. Epub 2010/04/03. doi: 10.1186/gb-2010-11-4-r36. PubMed PMID: 20359321; PMCID: 2884539.
  2. Suzuki M*, Oda M*, Ramos MP, Pascual M, Lau K, Stasiek E, Agyiri F, Thompson RF, Glass JL, Jing Q, Sandstrom R, Fazzari MJ, Hansen RS, Stamatoyannopoulos JA, McLellan AS, Greally JM. Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome. Genome Res. 2011;21(11):1833-40. Epub 2011/10/01. doi: 10.1101/gr.116509.110. PubMed PMID: 21957152; PMCID: 3205568. (* equal contribution)
  3. Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, Bhagat TD, Nischal S, Christopeit M, Parekh S, Steidl U, Godley L, Maitra A, Greally JM, Verma A. Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. Nucleic Acids Res. 2013;41(16):e157. doi: 10.1093/nar/gkt601. PubMed PMID: 23861445; PMCID: 3763560.
  4. Rastogi D, Suzuki M, Greally JM. Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Scientific reports. 2013;3:2164. doi: 10.1038/srep02164. PubMed PMID: 23857381; PMCID: 3712321.
  5. Berko ER, Suzuki M, Beren F, Lemetre C, Alaimo CM, Calder RB, Ballaban-Gil K, Gounder B, Kampf K, Kirschen J, Maqbool SB, Momin Z, Reynolds DM, Russo N, Shulman L, Stasiek E, Tozour J, Valicenti-McDermott M, Wang S, Abrahams BS, Hargitai J, Inbar D, Zhang Z, Buxbaum JD, Molholm S, Foxe JJ, Marion RW, Auton A, Greally JM. Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder. PLoS Genet. 2014;10(5):e1004402. doi: 10.1371/journal.pgen.1004402. PubMed PMID: 24875834; PMCID: 4038484.
  6. Li Q*, Suzuki M*, Wendt J, Patterson N, Eichten SR, Hermanson PJ, Green D, Jeddeloh J, Richmond T, Rosenbaum H, Burgess D, Springer NM, Greally JM. Post-conversion targeted capture of modified cytosines in mammalian and plant genomes. Nucleic Acids Res. 2015. doi: 10.1093/nar/gkv244. PubMed PMID: 25813045. (* equal contribution)

Complete List of Published Work in MyBibliography:


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