Science at the heart of medicine

7005A Molecular Cell Biology

Molecular Cell Biology is a single course with two parts (A & B). Part A is offered in Course Block II (3 credits) and Part B is offered in Course Block III (3 credits). Both parts A and B of the course must be taken in order to satisfy the course requirement. 

COURSE DESCRIPTION: This course will cover basic areas in cell biology with emphasis on selected topics of current interest. The three main areas will be intracellular protein transport, the nucleus, and the cytoskeleton. Topics will include: membrane structure and biogenesis, functions of intracellular membranes and the signal hypothesis, protein trafficking and intracellular sorting, glycosylation, exocytosis, endocytosis and membrane fusion, nuclear structure and organization, nuclear transport, mRNA localization, self assembly of cytoskeletal structures, actin, microtubules, intermediate filaments, molecular motors, mitosis, cell junctions and extracellular matrix, cytoskeleton and signal transduction, calcium as second messenger, and cilia.

REQUIRED MATERIALS: “Lewin’s CELLS” 2011, second edition; eds. L. Cassimeris, V.R. Lingappa, and G. Plopper; Jones and Bartlett Publishers; Sudbury, MA. http://biology.jbpub.com/lewin/cells; Reading the relevant chapter(s) prior to the lecture is required and es-sential for understanding the lectures. Several copies are on closed reserve in the library. The cheapest source for the book is Amazon (US$76.03). An elec-tronic version is available from CourseSmart ($93.95). Go to http://www.coursesmart.com/, type in “cells” in the search field and follow the instructions.

PREREQUISITES: This is a demanding course involving a substantial amount of reading and should only be taken by those first year students with a background in biochemistry and cell biology.

STUDENT PREPARATION: N/A

SUITABLE FOR 1ST YEAR STUDENTS: Yes

UNIQUE TRAINING OFFERED IN THIS COURSE: N/A

STUDENT ASSESSMENTS: 3 exams + 4TBLs

CREDIT HOURS: 6.0

Molecular Cell Biology is a single course with two parts (A & B). Part A is offered in Course Block II (3 credits) and Part B is offered in Course Block III (3 credits). Both parts A and B of the course must be taken in order to satisfy the course requirement.