Science at the heart of medicine

7013 Mechanisms of Disease

COURSE DESCRIPTION: This multidisciplinary course will investigate the pathobiology of human diseases and relevant animal models. Topics will include cellular pathology and the mechanisms of cell injury and repair. The course will emphasize the immunologic, molecular, genetic, and biochemical mechanisms that result in the gross and microscopic changes taking place within affected tissues. Types of injury to be explored in depth will include: biochemical/genetic (mechanisms of neurodegeneration and brain disorders, lysosomal storage diseases, expansion of trinucleotide repeats, chromosomal abnormalities), cancer, infectious, inflammatory, immunologic injury (Tuberculosis, Acquired Immunodeficiency Syndrome, Multiple Sclerosis, Malaria), and environmental (DNA damage). Minimum 12 students.

REQUIRED MATERIALS: Assigned Reading

PREREQUISITES: N/A

STUDENT PREPARATION: Background Knowledge of Immunology and Biochemistry is helpful.

SUITABLE FOR 1ST YEAR STUDENTS: Yes

UNIQUE TRAINING OFFERED IN THIS COURSE: This course will offer a broad perspective of pathologic mechanisms and aspects of disease. There is little overlap with existing courses.

STUDENT ASSESSMENTS: The course requirements will be assigned readings and open discussion, and 1-2 oral presentations of an assigned paper. Attendance is mandatory.

CREDIT HOURS: 3.0