COURSE DESCRIPTION: This course considers the variety of signaling systems that allow inputs from outside of a cell, such as growth factors, hormones and lipids, to regulate cellular behavior. The course comprises a detailed analysis of the mechanisms by which activation of intracellular and cell surface receptors control cell metabolism, motility, proliferation, survival, and covers the diverse mechanisms by which different classes of hormones, growth factors and lipids exert their actions. The course emphasizes a mechanistic understanding of how signaling proteins are regulated, a historical view of how signaling pathways were elucidated, and a practical approach to the tools used to study signal transduction.
A partial list of topics includes: receptor tyrosine kinases and their relationship to oncogene products; G-protein-coupled receptors and their coupling to adenylate cyclase, PI 3-kinases and phospholipases; protein-protein interaction domains in signal transduction; regulators of intracellular calcium and calcium-induced signaling via calmodulin- activated and calcium- phospholipid activated protein kinases; phosphoinositide kinases and their downstream effectors; small GTPases and their regulation of MAP Kinases; non-receptor tyrosine kinases and receptor serine/threonine kinases; the progesterone and glucocorticoid receptors and the central roles of steroid receptor-ligand complexes in controlling gene transcription; TGF signaling; and NFkB regulation of gene transcription and inflammation.
REQUIRED MATERIALS: Signal Transduction, Second Edition [Hardcover] Bastien D. Gomperts (Author), Ijsbrand M. Kramer (Author), Peter E.R. Tatham (Author) Elsevier, 2009, ISBN 978-0-12-369441-6
PREREQUISITES: Intermediate Biochemistry is desirable, but not absolutely necessary; graduate level understanding of protein structure and function, DNA structure & function also desirable.
STUDENT PREPARATION: N/A
SUITABLE FOR 1ST YEAR STUDENTS: Yes.
UNIQUE TRAINING OFFERED IN THIS COURSE: N/A
STUDENT ASSESSMENTS: N/A
CREDIT HOURS: 2.0