The Neuropathology Training Grant will support the training of predoctoral (1) and postdoctoral fellows (4) with state-of-the-art molecular approaches to disease-based neuropathology (requires citizenship or green card). The program is run by an 18-member, highly interactive training faculty with independent research funding and a long history of collaboration. The Program embraces colleagues in the departments of Pathology, Neuroscience, Developmental Molecular Biology, Cell Biology, Microbiology and Immunology and Genetics, with a particular focus on research into the pathogenesis of Alzheimer's disease, Multiple Sclerosis, NeuroAIDS, Lysosomal Storage diseases, and Parkinson's and Huntington's diseases. Trainees will use cutting-edge molecular, proteomic, structural, genetic and clinical approaches to investigate questions of fundamental importance to neurological diseases.