Research within the Infectious Disease focus ranges from studies of pathogen structure and biology to the investigation of pathogenetic mechanisms in the context of animal and cell culture models, and also includes translational studies that connect these models to human disease. Pathogens of special interest are HIV, Trypanosoma cruzi (the cause of Chagas’ disease), Plasmodium spp. (the cause of malaria), Toxoplasma gondii and microsporidia. Recent investigation has focused on the regulation of inflammatory signaling, the impact of pathogens on host metabolic functions, proteomic investigation of critical pathogen structures, the promotion of pathogenesis via the regulation of cell death and cell cycle pathways in host cells, and the development of novel mouse disease models. Clinical studies evaluate novel diagnostics for Point of Care testing.