LIVER PATHOLOGY FELLOWSHIP
There is one hepatopathology fellowship position available each year. Depending on the interests of the Fellow, the program can be one or two years in duration. The goal of the program is to give the Fellow a thorough grounding in diagnostic liver pathology and a broad understanding of the dynamic interface between liver pathology and hepatology for optimal care of patients. With fatty liver disease and hepatitis C at epidemic proportions in the United States (and, increasingly, worldwide), a detailed understanding of liver pathology is becoming increasingly valuable for even those pathologists committed to general surgical pathology practice.
Thus, first and foremost, the fellowship is focused on giving the Fellow a solid grounding in diagnostic liver pathology. The location of the diagnostic sign out room and the Fellow's desk in the Division of Digestive Diseases provides a unique opportunity for the Fellow to fully integrate liver pathology education with clinical hepatology by interacting directly with his/her neighbors: the clinical GI fellows and hepatologists in the division.
As the Fellow becomes familiar with liver pathology basics and demonstrates the ability to take on more teaching responsibility, presentation at case conferences at the Continuum Health Partners Network of hospitals will be shared with Dr. Theise. One presentation at the Division of Digestive Diseases weekly Grand Rounds will also be expected.
Research is also expected; the nature of such academic work depends on the interests and background of the Fellow and can be "in the lab" with a basic science stem cell/hepatic regeneration related project, or can be focused on clinical-path correlation work, often in collaboration with a clinical fellow. Beyond the essential training in diagnostic liver pathology, the Fellow is encouraged to be creative and pursue his/her own interests and inclinations for developing academic output. Presentation at one national meeting a year is encouraged. Submission and/or publication of at least one research paper by the end of the first year is expected.
Eligibility of applicants:
- Any Pathologist who has recently completed his/her residency
Please send all materials to:
Gayle Olton, Fellowship Coordinator
Beth Israel Medical Center
First Avenue at 16th Street, Suite 17BH50
New York, NY 10003
Telephone: (212) 420-4015
Fax: (212) 420-4373
To apply, please submit:
- Curriculum Vitae
- Personal statement
- Three letters of recommendation (LOR). One LOR should be from your residency program director.
- Deadline for submission for position beginning July 2007: February 1, 2006.
- The 2006-2007 position has been filled.
About Dr. Theise
Dr. Theise, an internationally recognized expert in diagnostic liver pathology and adult stem cell research, is active in clinical diagnostic liver pathology, clinico-pathologic correlation studies, and NIH funded basic science research. He is physically located in the Beth Israel Medical Center, Petrie Division, having an office and clinical sign-out room in the Division of Digestive Diseases, a "Liver and Stem Cell Research Laboratory" on 6th floor Singer Building in the same complex, and use of the animal facility at AECOM for basic science related animal research.
Current active research interests are quite broad and range from clinical-pathologic correlation efforts (e.g. PPAR-gamma expression in liver disease, the role of dysplastic nodules in human hepatocarcinogenesis, defining the microanatomy of the hepatic stem cell niche, liver regeneration in humans) to the basic (e.g. adult stem cell plasticity, animal models of hepatic regeneration), to the theoretical (e.g.applications of complexity theory for understanding biological phenomena, the role of stochasticity and "cellular uncertainty" in cell biology research). The breadth of his efforts is reflected in the diversity of journals in which his research has appeared, including Cell, Science, Nature, Lancet, Hepatology, Human Pathology, Cancer, Journal of Hepatology, Experimental Hematology, etc. He is a frequent lecturer at national and international level liver, pathology, and stem cell meetings.
With a dual appointment in the Depts of Medicine (Division of Digestive Diseases) and Pathology, he works closely with hepatologists at all the Continuum affiliate hospitals, responsible for all hepatopathology deriving from the several institutions, teaching clinical GI fellows and pathology resident/fellows, running regular clinical case conferences at all the centers, and overseeing research projects of interested individuals at all levels of training and practice.
Selected from approximately 100 PAPERS IN PEER REVIEWED JOURNALS
1. Saxena R, Theise ND, Crawford JM. Microanatomy of the human liver -- exploring the hidden interfaces. Hepatology 1999; 30:1339-46.
2. Theise ND, Saxena R, Portmann BP, Thung SN, Yee H, Chiriboga L Kumar A, Crawford JM. The canals of hering and hepatic stem cells in humans. Hepatology 1999; 30:1425-33 (featured on cover).
3. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of Hepatocytes From Bone Marrow Cells in Mice After Radiation-Induced Myeloablation. Hepatology 2000; 31: 235-240 (featured on cover).
4. Theise ND, Park YN, Thung SN. "Vascular profiles" of regenerative and dysplastic nodules. Hepatology. 2000; 31: 1380-1.
5. Theise ND, Nimmakayalu M, Gardner R, Illei P, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology 2000; 32: 11-16. (Featured on cover; Selected as “most important contribution to Hepatology” in prior five year period by Editor in Chief E. Montgomery Bissell).
6. Theise ND, Krause DS, Mehal W, Illei PB. Liver stem cells from bone marrow. Hepatology 2000; 32: 1180 (letter).
7. Krause DS*, Theise ND*, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369-377. (*contributed equally)
8. Theise ND, Krause DS. Suggestions for a new paradigm of cell differentiative potential. Blood Cells, Molecules, and Diseases 2001; 27: 625-631.
9. Park YN, Chae KJ, Kim YB, Park C, Theise ND. Increased activity of apoptosis and proliferation in human multistep hepatocarcinogenesis. Cancer 2001; 92: 2733-8.
10. Theise ND, Krause DS. Toward a new paradigm of cell differentation capacity. Leukemia 2002; 16: 542-8.
11. Theise ND, Park YN, Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clinics Liver Dis [Invited Review] 2002; 6: 497-512.
12. Tan JY, Hytiroglou P, Wieczorek R, Park YN, Thung SN, Arias B, Theise ND. Immunohistochemical evidence for hepatic progenitor cells in liver diseases. Liver 2002; 22: 365-373.
13. Saxena R, Hytiroglou P, Thung SN, Theise ND. Destruction of canals of Hering in primary biliary cirrhosis. Hum Pathol 2002; 33: 983-988.
14. Gaglio PJ, Liu HF, Dash S, Cheng S, Dunne B, Ratterree M, Baskin G, Blanchard J, Bohm Jr, R, Theise ND, LaBrecque D. Liver regeneration investigated in a non-human primate model (Macaca mulatta). J Hepatol 2002; 37: 625-632.
15. Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice: A severe injury model for pneumocyte engraftment from bone marrow-derived cells. Exp Hematology 2002; 30: 1333-1338.
16. Grove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. Bone marrow transplantation for the delivery of gene therapy to non-hematopoietic organs. Am J Respir Cell Mol Biol. 2002; 27: 645-51 [Featured on cover].
17. Theise ND, Krause DS. Bone marrow to liver: The blood of Prometheus. Semin Cell Dev Biol. 2002; 13: 411-7 [Invited review].
18. Theise ND. New principles of cell plasticity. Comptes Rendus Biologies (Academie des Sciences, Paris) 2003; 325: 1039-43 [Invited review].
19. Theise ND, Krause DS, Sharkis S. Comments on: “Little evidence for stem cell plasticity.” Science 2003; 299: 1317.
20. Ianus IA, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. JCI 2003; 111: 843-50 [Featured on cover].
21. Theise ND. Liver stem cells: prospects for treatment of inherited and acquired liver diseases. Expert Opin Biol Ther 2003; 3: 403-8.
22. Theise ND. Stem cell research: elephants in the room. Mayo Clinic Proc 2003; 78: 1004.
23. Theise ND, Wilmut I. Cell plasticity: flexible arrangement. Nature 2003; 425: 21.
24. Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, Tsui W, Ohta H, Nakanuma Y. Hepatic "stem cell" malignancies in adults: four cases. Histopathology 2003; 43: 263-271.
25. Falkowski O, An HJ, Ianus IA, Chiriboga L, Yee H, West AB, Theise ND. Regeneration of hepatocyte “buds” in cirrhosis from intrabiliary stem cells. J Hepatology 2003; 39: 357-364.
26. Theise ND. Liver stem cells: the fall and rise of tissue biology. Hepatology 2003; 38: 804-806.
27. Theise ND. Stem cells react! Cell lineages as complex reactive systems. Exp Hematology 2004; 32: 25-27.
28. Hytiroglou P, Tobias H, Saxena R, Abramidou M, Papadimitriou CS, Theise ND. The canals of Hering may represent a target of methotrexate toxicity. Am J Clin Path 2004; 121: 324-9.
29. Saxena R, Theise ND. Canals of Hering: recent insights and current knowledge. Semin Liver Dis. 2004; 24: 43-8.
30. Kofman AV, Theise ND, Hussain MA. Paradigms of adult stem cell therapy for type 1 diabetes in mice. Eur J Endocrinol. 2004; 150: 415-9.
31. Roskams TA*, Theise ND*, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, Brunt EM, Crawford JM, Crosby HA, Desmet V, Finegold MJ, Geller SA, Gouw ASH, Hytiroglou P, Knisely AS, Kojiro M, Lefkowitch JH, Nakanuma Y, Olynyk JK, Park YN, Portmann B, Saxena R, Scheuer PJ, Strain AJ, Thung SN, Wanless IR, West AB. Nomenclature of the finer branches of the biliary tree: canals, ductules and ductular reactions in human livers. Hepatology 2004; 39: 1739-1745. [*contributed equally]
32. Hussain MA, Theise ND. Stem dell therapy for diabetes mellitus: Recent developments and possible mechanisms. Lancet 2004; 364: 203-5. [Invited review].
33. Newsome PN, Hussain MA, Theise ND. Hepatic oval cells: helping redefine a paradigm in stem cell biology. Curr Top Dev Biol 2004; 61: 1-28.
34. Theise ND. Restoring the balance in liver stem cell research. J Hepatol. 2004; 41: 673-6 [Invited editorial].
35. Borue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS. Bone marrow derived stem cells are recruited to wounded skin, and contribute to epithelial engraftment during healing. Am J Pathology [In press].
1. Hirohashi S, Kojiro M, Wanless IR, Theise ND. Hepatocellular Carcinoma. In: Hamilton S, Aaltonen L (eds): WHO Classification of Tumors (vol. 2): Pathology and Genetics of Tumours of the Digestive Tract. 2000.
2. Ferrell L, Theise ND, Scheuer PJ. Viral hepatitis: In: MacSween R, Ishak K, Portmann B, Scheuer PJ, Anthony PP: Pathology of the liver (4th edition). London UK: Saunders and Co. 2001.
3. Theise ND, Bodenheimer H, Ferrell L. Viral hepatitis: In: MacSween R, Ishak K, Portmann B, Scheuer PJ, Anthony PP: Pathology of the liver (5th edition). London UK: Saunders and Co. 2005 [In press].
4. D’Inverno M, Theise ND, Prophet J. Mathematical modeling of stem cells: A complexity primer for the stem cell biologist. In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications (2nd edition), Marcell Dekker Inc, New York NY, 2004 [In press].
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