Department of Pathology

Department Faculty

Sankar Mukhopadhyay, Ph.D.

Dr. Sankar Mukhopadhyay
 

Professional Interests

Our laboratory focuses on the role of eicosanoids in the development of Chagas Disease. We reported that the protozoan parasite, Trypanosoma cruzi (causative agent of Chagas disease) is capable of synthesizing several eicosanoid species including prostaglandin F2a and thromboxane A2 (TXA2). As Chagas disease is a vasculopathy, it is important to study the TXA2 signaling in T. cruzi, particularly because TXA2 is the most potent vasoactive molecule known and TXA2 signaling through both parasite and host modulates Chagas disease pathogenesis.  Recently we observed that the parasite TXA2 biosynthetic pathway is sensitive to aspirin treatment and possibly parasites scavenge PGH2 from the host. We believe that TcTXA2 not only controls parasite replication by acting as a quorum lipid but also controls inflammation to maintain the prolonged intermediate stage observed in the Chagas disease. The finding that the parasite derived eicosanoids can interact with the host arachidonic acid metabolic pathway is of immense clinical importance. A deeper understanding of the interplay of the parasite and host derived vasoactive substances in this infection may lead to the development of new strategies for drug design and treatment.

 

Selected Publications

  1. Mukherjee, S., Bhattacharyya, S., and S. Adhya (1999). Stepwise transfer of tRNA through the double membrane of Leishmania mitochondria. Journal of Biological Chemistry, 274(44):31249-31255.
  2. Bhattacharyya, S., Mukherjee, S., and S. Adhya (2000). Mutations in the tRNA import signals define distinct receptors at the two membranes of Leishmania mitochondria. Molecular and Cellular Biology, 20(19):7410-7417.
  3. Jelicks, L.A., Chandra, M., Shirani, J., Shtutin, V., Tang, B., Christ, G.J., Factor, S.M., Wittner, M., Huang, H., Weiss, L.M., Mukherjee, S., Bouzahzah, B., Petkova, S.B., Teixeira, M.M., Douglas, S.A., Loredo, M.L., D'Orleans-Juste, P., and H.B. Tanowitz (2002). Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. International journal of Parasitology, 32(12):1497-1506.
  4. Mukherjee, S., Huang, H., Weiss, L.M., Costa, S., Scharfstein, J., and H.B. Tanowitz (2003). Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience, 8:e410-9. Review.
  5. Huang, H., Petkova, S.B., Cohen, A.W., Bouzahzah, B., Chan, J., Zhou, J.N., Factor, S.M., Weiss, L.M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R.N., Pestell, R.G., Lisanti, M.P., Albanese, C., and H.B. Tanowitz (2003). Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infection and Immunity, 71(5):2859-2867.
  6. Mukherjee, S., Belbin, T.J., Spray, D.C., Iacobas, D.A., Weiss, L.M., Kitsis, R.N., Wittner, M., Jelicks, L.A., Scherer, P.E., Ding, A., and H.B. Tanowitz (2003). Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy. Parasitology Research, 91(3):187-196.
  7. Huang, H., Petkova, S.B., Cohen, A.W., Bouzahzah, B., Chan, J., Zhou, J.N., Factor, S.M., Weiss, L.M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R.N., Pestell, R.G., Lisanti, M.P., Albanese, C., and H.B. Tanowitz (2003). Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infection and Immunity, 71(5):2859-2867.
  8. Mukherjee, S., Huang, H., Petkova, S.B., Albanese, C., Pestell, R.G., Braunstein, V.L., Christ, G.J., Wittner, M., Lisanti, M.P., Berman, J.W., Weiss, L.M. and H.B. Tanowitz (2004). Trypanosoma cruzi infection activates extra cellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Infection and Immunity, Sep;72(9):5274-82.
  9. Tanowitz, H.B., Huang, H., Jelicks, L.A., Chandra, M, Loredo, M.L., Weiss, L.M., Factor, S.M., Shtutin, V., Mukherjee, S., Kitsis, R.N., Christ, G.J., Wittner, M., Shirani, J., Kisanuki, Y.Y. and M. Yanagisawa (2005). Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infection and Immunity, Apr;73(4):2496-503.
  10. Combs, T.P., Nagajyothi, FNU, Mukherjee, S., Lin Ying, Jayabalan, D.S., Lisanti, M.P. and H.B. Tanowitz (2005). The adipocyte as an important target cell for Trypanosoma cruzi infection. Journal of Biological Chemistry, 280(25):24085-24094.
  11. Mukherjee, S., Belbin, T.J., Spray, D.C., Mukhopadhyay, A., Nagajyothi, F., Weiss, L.M. and H.B. Tanowitz (2006). Microarray technology in the investigation of diseases of myocardium with special reference to infection. Frontiers in Biosciences, 11:1802-1813.
  12. Hassan, G.S., Mukherjee, S., Nagajyothi, F., Weiss, L.M., Petkova, S.B., de Almeida, C.J., Huang, H., Desruisseaux, M.S., Bouzahzah, B., Pestell, R.G., Albanese, C., Christ, G.J., Lisanti, M.P. and H.B. Tanowitz (2006). Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infection and Immunity, 74(1):152-159.
  13. Ashton, A.*, Mukherjee, S.*, Nagajyothi, FNU., Huang, H., Braunstein, V.L., Lopez, L., Berman, J.W., Wittner, M., Scherer, P.E., Capra, V., Coffman, T.M., Serhan, C.N., Gotlinger, K., Wu, K.K., Weiss, L.M. and H.B. Tanowitz (2007). Thromboxane A2 is a key regulator in the pathogenesis during Trypanosoma cruzi infection. Journal of Experimental Medicine, Apr 16;204(4):929-940.     * Joint first author
  14. Bouzahzah, B., Yurchenko, V., Nagajyothi, F., Hulit, J., Sadofsky, M., Braunstein, V.L., Mukherjee, S., Weiss, H., Machado, F.S., Pestell, R.G., Lisanti, M.P., Tanowitz, H.B. and C. Albanese (2008). Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts. Cell Cycle, Feb 15;7(4):500-503.
  15. Mukherjee, S., Nagajyothi, F., Mukhopadhyay, A., Machado, F.S,. Belbin, T.J., Campos de Carvalho, A., Guan, F., Albanese, C., Jelicks, L.A., Lisanti, M.P., Silva, J.S., Spray, D.C., Weiss, L.M., and H.B. Tanowitz (2008). Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection. Genomics, May;91(5):423-432.
  16. Ny, L., Li, H., Mukherjee, S., Persson, K., Holmqvist, B., Zhao, D., Shtutin, V., Huang, H., Weiss, L.M., Machado, F.S., Factor, S.M., Chan, J., Tanowitz, H.B. and L.A. Jelicks (2008). A magnetic resonance imaging study of intestinal dilation in Trypanosoma cruzi-infected mice deficient in nitric oxide synthase. American Journal for Tropical Medical and Hygiene,  Nov;79(5):760-767.
  17. Villalta F, Scharfstein J, Ashton AW, Tyler KM, Guan F, Mukherjee S, Lima MF, Alvarez S, Weiss LM, Huang H, Machado FS and H.B. Tanowitz (2009). Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitology Research, Jun;104(6):1251-1260.
  18. Durand, J.L., Mukherjee, S., Commodari, F., De Souza, A.P., Zhao, D., Machado, F.S., Tanowitz, H.B.and L.A. Jelicks (2009). Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice. American Journal for Tropical Medical and Hygiene, May;80(5):782-787.
  19. Machado, F.S., Mukherjee, S., Weiss, L.M., Tanowitz, H.B/, Ashton, A.W (2011). Bioactive Lipids in Trypanosoma cruzi Infection. Adv Parasitol. 2011;76:1-31. PMID:21884885
  20. Tanowitz, H.B., Mukhopadhyay, A., Ashton, A.W., Lisanti, M.P., Machado, F.S., Weiss, L.M., Mukherjee, S.  (2011) Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction. Cell Cycle. 2011 Apr 1;10(7):1132-43. PMID:21364319
  21. Mukherjee, S., Machado, F.S., Huang, H., Oz, H.S., Jelicks, L.A., Prado, C.M., Koba, W., Fine, E.J., Zhao, D., Factor, S.M., Collado, J.E., Weiss, L.M., Tanowitz, H.B., Ashton, A.W. (2011) Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. PLoS One. Feb 15;6(2):e16959.
 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 504
Bronx, NY 10461

Tel: 718.430.2143
sankar.mukhopadhyay@einstein.yu.edu

 
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