Huan Huang, M.D.
Dr. Huan Huang conducts the studies on Trypanosoma cruzi (T. cruzi), a parasite which causes Chagas disease. The researches include molecular biology of the parasite, pathogenesis of Chagas disease and the genetic techniques in this organism. His laboratory studies protein kinases and kinase signaling pathways in T. cruzi. The laboratory has identified and characterized components in cAMP-dependent protein kinase (PKA) and Mitogen activated protein kinase pathways in T. cruzi and published several manuscripts on cAMP-PKA signaling and mitogen activated protein kinases in T. cruzi. These findings have established a solid basis for further research in this pathogen and the knowledge can be used for drug development. His group also studies Eicosanoids signaling in T. cruzi. Recently, his group advanced molecular genetics in T. cruzi by designing a modified pTREX vector which uses an N-terminal fusion of a ligand-controlled destabilization domain (ddFKBP) to a gene/protein of interest. This vector system allows rapid and reversible protein expression and efficient functional analysis of proteins in different T. cruzi life cycle stages. In addition, his group is creacting transgenic T. cruzi for the study of disease mechanism and for vacine strains.
Bao Y, Weiss LM, Braunstein VL, Huang, H. (2008) The role of protein kinase A in Trypanosoma cruzi . Infection and Immunity 76:4757-63(Spotlighted)
Bao Y, Weiss LM, Hashimoto M, Nara T, and Huang H (2009) Protein kinase A regulatory subunit interacts with P- type ATPases in Trypanosoma cruzi Am J Trop Med Hyg. 80(6):941-3.
Bao Y, Weiss LM, Ma YF, Kahn S, and Huang H.(2010) Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi. Microbes and Infection 202(7):1104-13.
Bao Y, Weiss LM , Ma YF, Lisanti MP, Tanowitz HB, Das BC, Zheng R and Huang H.(2010) Molecular cloning and characterization of Mitogen-activated protein kinase 2 in Trypanosoma cruzi. Cell Cycle 2010 Jul 15;9(14):2888-96. Epub 2010 Jul 13.
Huang H (2011) Signal transduction in Trypanosoma cruzi (review) Advance in Parasitology. 2011; 75:325-44.
Taylor MC, Huang H, Kelly JM (2011) Genetic Techniques in Trypanosoma cruzi (review) Advance In Parasitology, 75:231-50.
Ma YF, Weiss LM, Huang H (2012). A method for rapid regulation of protein expression in Trypanosoma cruzi. Int J Parasitol. 42:33-37.
More Information About Dr. Huan Huang
Protein kinase A; Trypanosoma cruzi; Chagas disease; Mitogen-activated Protein kinase
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.