Department of Pathology

Department Faculty

Johnny C. Loke, M.S.

Dr. Johnny C. Loke
 

Professional Interests

Experienced in collaborative project managment, gene expression screening by flow cytometry and assay developement, creating transgenic cell lines. Designing PK study models (pre-clinical), and designing target validations from Next Generation Sequencing datasets. Oversee lab operation and support grant prep and applications.

 

A project coordinator/ leader for several cancer and developmental genomic studies at Albert Einstein College of Medicine.

Currently, working to develop rapid cancer diagnostic testing using targeted genome sequencing platform for metastatic cancer patients. Developed a proof-of-concept for detecting functional effects of genetic variants of uncertainty using proteomics and flow cytometry.

 

Specialties

Molecular Medicine

 

Selected Publications

Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.

Pearlman A, Loke J, Le Caignec C, White S, Chin L, Friedman A, Warr N, Willan J, Brauer D, Farmer C, Brooks E, Oddoux C, Riley B, Shajahan S, Camerino G, Homfray T, Crosby AH, Couper J, David A, Greenfield A, Sinclair A, Ostrer H.

Am J Hum Genet. 2010 Dec 10;87(6):898-904. PMID: 21129722

 

Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP).

Lee TF, Mak KM, Rackovsky O, Lin YL, Kwong AJ, Loke JC, Friedman SL.

J Cell Physiol. 2010 Jun;223(3):648-57. PMID: 20143336

 

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

Guo J, Hong F, Loke J, Yea S, Lim CL, Lee U, Mann DA, Walsh MJ, Sninsky JJ, Friedman SL.

J Biol Chem. 2010 Feb 19;285(8):5428-37. Epub 2009 Dec 17. PMID: 20022962

 

Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation.

Hong F, Tuyama A, Lee TF, Loke J, Agarwal R, Cheng X, Garg A, Fiel MI, Schwartz M, Walewski J, Branch A, Schecter AD, Bansal MB.

Hepatology. 2009 Jun;49(6):2055-67. PMID: 19434726

 

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.

Guo J, Loke J, Zheng F, Hong F, Yea S, Fukata M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL.

Hepatology. 2009 Mar;49(3):960-8. PMID: 19085953

 

Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

Yea S, Narla G, Zhao X, Garg R, Tal-Kremer S, Hod E, Villanueva A, Loke J, Tarocchi M, Akita K, Shirasawa S, Sasazuki T, Martignetti JA, Llovet JM, Friedman SL.

Gastroenterology. 2008 May;134(5):1521-31. Epub 2008 Feb 13. Erratum in: Gastroenterology. 2008 Jul;135(1):326. PMID: 18471523

 

Predictive modeling of plant messenger RNA polyadenylation sites.

Ji G, Zheng J, Shen Y, Wu X, Jiang R, Lin Y, Loke JC, Davis KM, Reese GJ, Li QQ.

BMC Bioinformatics. 2007 Feb 7;8:43. PMID: 17286857

 

Compilation of mRNA polyadenylation signals in Arabidopsis revealed a new signal element and potential secondary structures.

Loke JC, Stahlberg EA, Strenski DG, Haas BJ, Wood PC, Li QQ.

Plant Physiol. 2005 Jul;138(3):1457-68. Epub 2005 Jun 17. PMID: 15965016

 

Rapidly screening variants of uncertain significance in the MAP3K1 gene for phenotypic effects.

Loke J, Ostrer H.

Clin Genet. 2012 Mar;81(3):272-7. doi: 10.1111/j.1399-0004.2011.01834.x. Epub 2012 Jan 11. PMID: 22171599

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Ullmann Building, Room 709
Bronx, NY 10461

Tel: 718.430.8607
Fax: 718.430.8541
johnny.loke@einstein.yu.edu

 
Pubmed Search
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