Department of Pathology

Department Faculty

Cristina C. Clement, Ph.D.

Dr. Cristina C. Clement

Research Assistant Professor, Department of Pathology

 

Professional Interests

To date my primary scientific interest in biochemistry has focused on exploring and uncovering different aspects of molecular recognition processes, specifically the molecular responses that are activated and deactivated by various pathological conditions such as autoimmune diseases and cancer.

    My investigations at Albert Einstein College of Medicine, Pathology department, conducted in the lab of Professor Laura Santambrogio, are focused primarily on the discovery of new immunodominant peptides derived from collagen-I and II processing by metalloproteases on the plasma membrane of dendritic cells.

    We are using peptidomics and proteomics approaches, such as high resolution mass spectroscopy ESI-LTQ and MALDI-Tof-Tof MS/MS to sequence more than 400 peptides isolated from the human lymph to determine the self-peptidomic carrying ability of the lymph. 

 

Selected Publications

1.

Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators.

Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G.

Assay Drug Dev Technol. 2010 Dec 6. [Epub ahead of print]PMID: 21133677 [PubMed - as supplied by publisher]Related citations

2.

The lymph as a pool of self-antigens.

Clement CC, Rotzschke O, Santambrogio L.

Trends Immunol. 2010 Dec 1. [Epub ahead of print]PMID: 21123113 [PubMed - as supplied by publisher]Related citations

3.

An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma.

Clement CC, Cannizzo ES, Nastke MD, Sahu R, Olszewski W, Miller NE, Stern LJ, Santambrogio L.

PLoS One. 2010 Mar 26;5(3):e9863.PMID: 20360855 [PubMed - in process]Free PMC ArticleFree textRelated citations

4.

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis.

Maitra R, Clement CC, Scharf B, Crisi GM, Chitta S, Paget D, Purdue PE, Cobelli N, Santambrogio L.

Mol Immunol. 2009 Dec;47(2-3):175-84. Epub 2009 Oct 4.PMID: 19804908 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

5.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. Epub 2009 May 5.PMID: 19416831 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

6.

Isothermal titration calorimetry and inhibition of platelets aggregation by [D-Phe/(transcinnamoyl)-Pro-D-Arg-P1'-CONH2] peptides inhibitors of thrombin.

Clement CC, Babinska A, Kornecki E, Philipp M.

Adv Exp Med Biol. 2009;611:579-80. No abstract available. PMID: 19400322 [PubMed - indexed for MEDLINE]Related citations

7.

Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.

Champeil E, Paz MM, Ladwa S, Clement CC, Zatorski A, Tomasz M.

J Am Chem Soc. 2008 Jul 23;130(29):9556-65. Epub 2008 Jun 28.PMID: 18588303 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

8.

Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation.

Maitra R, Clement CC, Crisi GM, Cobelli N, Santambrogio L.

PLoS One. 2008 Jun 18;3(6):e2438.PMID: 18560588 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

9.

The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.

Goeckeler JL, Petruso AP, Aguirre J, Clement CC, Chiosis G, Brodsky JL.

FEBS Lett. 2008 Jul 9;582(16):2393-6. Epub 2008 Jun 6.PMID: 18539149 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

10.

Design of a fluorescence polarization assay platform for the study of human Hsp70.

Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, Chiosis G.

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3749-51. Epub 2008 May 16.PMID: 18515098 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

11.

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G.

Nat Chem Biol. 2007 Aug;3(8):498-507. Epub 2007 Jul 1.PMID: 17603540 [PubMed - indexed for MEDLINE]Related citations

12.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.PMID: 16797988 [PubMed - indexed for MEDLINE]Related citations

13.

DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo.

Utzat CD, Clement CC, Ramos LA, Das A, Tomasz M, Basu AK.

Chem Res Toxicol. 2005 Feb;18(2):213-23.PMID: 15720125 [PubMed - indexed for MEDLINE]Related citations

14.

Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.

Subramaniam G, Paz MM, Suresh Kumar G, Das A, Palom Y, Clement CC, Patel DJ, Tomasz M.

Biochemistry. 2001 Sep 4;40(35):10473-84. Erratum in: Biochemistry 2001 Oct 23;40(42):12746. PMID: 11523988 [PubMed - indexed for MEDLINE]Related citations

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 138
Bronx, NY 10461

Tel: 718.430.3468
Fax: 718.430.8541
cristina.clement@einstein.yu.edu

 
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