Cristina C. Clement, Ph.D.
To date my primary scientific interest in biochemistry has focused on exploring and uncovering different aspects of molecular recognition processes, specifically the molecular responses that are activated and deactivated by various pathological conditions such as autoimmune diseases and cancer.
My investigations at Albert Einstein College of Medicine, Pathology department, conducted in the lab of Professor Laura Santambrogio, are focused primarily on the discovery of new immunodominant peptides derived from collagen-I and II processing by metalloproteases on the plasma membrane of dendritic cells.
We are using peptidomics and proteomics approaches, such as high resolution mass spectroscopy ESI-LTQ and MALDI-Tof-Tof MS/MS to sequence more than 400 peptides isolated from the human lymph to determine the self-peptidomic carrying ability of the lymph.
Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators.
Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G.
Assay Drug Dev Technol. 2010 Dec 6. [Epub ahead of print]PMID: 21133677 [PubMed - as supplied by publisher]Related citations
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. Epub 2009 May 5.PMID: 19416831 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G.
Nat Chem Biol. 2007 Aug;3(8):498-507. Epub 2007 Jul 1.PMID: 17603540 [PubMed - indexed for MEDLINE]Related citations
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