Department of Pathology

Hematology

Director

Dr. Jacob Rand, Professor of Pathology, has over 25 years of experience in directing Hematology and specialty labs. Dr. Rand trained in Autopsy Pathology at Montefiore, Internal Medicine at Mount Sinai Medical Center (NY), and Hematology at Montefiore. He also spent three post-doctoral years performing research at Montefiore. His major professional interests include optimizing the utilization of laboratories by clinicians, improving laboratory education, and researching the pathophysiology of the antiphospholipid syndrome. He is the author of about 85 research articles and more than a dozen textbook chapters (Link to Pubmed).

Phone: 718-920-6430
Fax: 718-881-2666

Montefiore Medical Center
Department of Pathology
111 East 210th Street
Bronx, NY 10467

 

Overview

The Hematology, Advanced Coagulation and Protein Separation Laboratories provide state-of-the-art testing for general screening and for diagnostic evaluation of patients with blood abnormalities. The laboratory also performs more complex tests that are used to evaluate patients with coagulation disorders, plasma cell dyscrasias, diagnosis of hemoglobin-opathies, and special hematology tests.

Our goals are to provide a four-month experience that will give you a solid base of knowledge about how all of these tests are performed and interpreted, how clinicians use – and sometimes misuse – these tests, how to communicate results and advice in a way that best serves the patient, how to manage a clinical laboratory, how to think about the tests that we do in a critical and innovative manner, and how to implement new tests.

As a pathology resident in our program, you will rotate through these labs for three consecutive months. The educational experience is then solidified by one month of direct exposure to patients in the Clinical Hematology Consult Service at Montefiore Medical Center. There, you will work with the clinical hematology team and gain first- hand experience in evaluating patients with hematologic complications.

Residents meet with the lab’s director virtually every day. We strive to maximize case-based learning through signouts that are supplemented by didactic teaching. The resident learns the principles of all the tests that are done by the labs, along with their clinical applications, diagnostic utilities and limitations. Residents also join the director on Tuesday mornings to see patients referred to our special consultation clinic. There are weekly conferences in Thrombosis & Hemostasis (Mondays), Hematology Grand Rounds (Fridays), and biweekly Clinical Pathology Grand Rounds (Thursdays). The residents also attend our monthly meetings with the entire laboratory staff that address technical, regulatory, and quality-of-life issues. Over the course of the rotation, each resident also completes a scholarly project, presents one journal club or case presentation with literature review, and does one in-service educational session for the laboratory staff.

Facilities

The Core Hematology Laboratory performs the routine tests including complete blood counts, blood cell differentials, reticulocyte counts, erythrocyte sedimentation rates, prothrombin times, partial thromboplastin times, and D-dimer assays.

The Advanced Coagulation Laboratory performs specialized evaluations for bleeding and thrombotic disorders including coagulation factor analyses, von Willebrand factor analyses, platelet aggregation studies and thrombophilia panels.

The Protein Separation Laboratory does protein and hemoglobin electrophoreses, immunofixation assays, cryoglobulins and quantitative immunoglobulins.

Research Opportunities

Residents are invited to participate in the many research opportunities. We especially like to promote research that is resident-initiated and stimulated by the recognition of a clinical laboratory issue that the resident would like to address in a systematic basis. We are also open to fostering lab-related research that that translates basic science methods to clinical applications. Examples of the projects that recent residents have worked on include: a new flow cytometric assay for antiphospholipid antibodies (Dr. Lisa Senzel), a computer-based system for managing D-dimer testing for suspected DVT/PE (Drs. Vicky Saksenberg-Krengel and Christina Day), an evaluation of the appropriateness and usefulness of thrombophilia testing in the real world setting (Dr. Jonathan Somma), modification of immunofixation electrophoresis to reduce artifacts (Dr. Mark Williams), misdiagnosis of syphilis and antiphospholipid syndrome (Dr. Kazuki Harada).

 

 

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