Department of Pathology

Recently Published Research

Here is a sampling of research studies by Pathology Department faculty members published in peer-reviewed scientific journals over the past year:


Beck AP, Magden ER, Buchl SJ, Baze WB. Malignant Neoplasia of the Sex Skin in Two Chimpanzees (Pan troglodytes). Comp Med. 2016; 66(2):154-161. 


Beck AP, Gray SB, Chaffee BK. Disseminated Hemangiosarcoma in a Juvenile Rhesus Macaque (Macaca mulatta). Comp Med. 2016; 66(3):246-53.


Chaffee BK, Beck AP, Owston MA, Kumar S, Baze WB, Magden ER, Dick EJ, Lammey M, Abee CR. Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees. Vet Pathol. 2016; 53(2):425-35.


Smith PC, Zeiss CJ, Beck AP, Scholz JA. Demodex musculi Infestation in Genetically Immunomodulated Mice. Comp Med. 2016; 66(4):278-85.


Chandra D, Selvanesan BC, Yuan Z, Libutti SK, Koba W, Beck A, Zhu K, Casadevall A, Dadachova E, Gravekamp C. 32-phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect. Oncotarget. 2017; Epub 2/6/17.


Zeiss CJ, Allore H, Beck AP. Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease. PLoS ONE. 2017;12(2):e0171790.


Beck AP, Shima AL, Bennett MD, Johnson LK. Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus). Vet Sci. 2017;4(1):10.


Fooksman, D and Lauvau, G. STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. PLOS Pathogens. October 28, 2016.


Desruisseaux, M. Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral MalariaPLOS Pathogens. March 31, 2016 


Labovitz D,  Shafner L, Reyes Gil M, Virmani D, Hanina A. Using Artificial Intelligence to Reduce the Risk of Nonadherence in Patients on Anticoagulation Therapy. Accepted for publication in STROKE.


Dietary and Genetic Influences on Hemostasis in a Yup’ik Alaska Native Population. Au NT, Reyes M, Boyer BB, Hopkins SE,  Black J,  O’Brien J,   Fohner AE, Yracheta5, Thornton JT, Austin MA, Burke W, Thummel KE, Rettie AE. Accepted for publication in PloSOne.


Ieronimakis N, Hays A, Prasad A, Janebodin K, Duffield J, Reyes M. PDGFRα signaling promotes fibrogenic responses in collagen producing cells in Duchene Muscular Dystrophy. Journal of Pathology. 2016 Dec;240(4):410-424. doi: 10.1002/path.4801. PMID 27569721 


Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Tanase M, Urbanska AM, Zolla V, Clement CC, Huang L, Morozova K, Follo C, Goldberg M, Roda B, Reschiglian P, Santambrogio L. Sci Rep. 2016 Jan 18;6:19311. doi: 10.1038/srep19311.


The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity. Clement CC, Becerra A, Yin L, Zolla V, Huang L, Merlin S, Follenzi A, Shaffer SA, Stern LJ, Santambrogio L.


J Biol Chem. 2016 Mar 11;291(11):5576-95. doi: 10.1074/jbc.M115.655738. The melting pot of the MHC II peptidomeStern LJ, Santambrogio L. Curr Opin Immunol. 2016 Jun;40:70-7. doi: 10.1016/j.coi.2016.03.004. Review. 


Autoimmune response to transthyretin in juvenile idiopathic arthritis. Clement CC, Moncrieffe H, Lele A, Janow G, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L. JCI Insight. 2016 Feb;1(2). pii: e85633.


Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L. J Biol Chem. 2016 Aug 26;291(35):18096-106. doi: 10.1074/jbc.M116.736744.


Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. Ben-Dayan MM, Ow TJ, Belbin TJ, Wetzler J, Smith RV, Childs G, Diergaarde B, Hayes DN, Grandis JR, Prystowsky MB, Schlecht NF. Cancer Med. 2017 Feb;6(2):397-407. doi: 10.1002/cam4.961. PMID: 28102032


Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. Tilston-Lünel AM, Haley KE, Schlecht NF, Wang Y, Chatterton AL, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA. J Mol Cell Biol. 2016 Apr 18. [Epub ahead of print] PMID: 27190314


Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach to nephrotic disease. Pullman JM, Nylk J, Campbell EC, Gunn-Moore FJ, Prystowsky MB, Dholakia K. Biomed Opt Express. 2016 Jan 6;7(2):302-11. doi: 10.1364/BOE.7.000302. PMID: 26977341


Comparative Monomethylarginine Proteomics Suggests that PRMT1 is a Significant Contributor to Arginine Monomethylation in Toxoplasma gondii. Yakubu RR, Silmon de Monerri NC, Nieves E, Kim K, Weiss LM. Mol Cell Proteomics. 2017 Jan 31. pii: mcp.M117.066951. doi: 10.1074/mcp.M117.066951. [Epub ahead of print] PMID: 28143887


A New Development in Trypanosoma cruzi Detection. Tanowitz HB, Weiss LM. J Clin Microbiol. 2017 Mar;55(3):690-692. doi: 10.1128/JCM.02353-16. PMID: 28077696


Making Home Sweet and Sturdy: Toxoplasma gondii ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity. Tomita T, Sugi T, Yakubu R, Tu V, Ma Y, Weiss LM. MBio. 2017 Jan 10;8(1). pii: e02048-16. doi: 10.1128/mBio.02048-16. PMID: 28074022


Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. Parasitol Res. 2017 Mar;116(3):827-838. doi: 10.1007/s00436-016-5350-5. Review. PMID: 28013375


Endothelin-1 Treatment Induces an Experimental Cerebral Malaria-Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65. Martins YC, Freeman BD, Akide Ndunge OB, Weiss LM, Tanowitz HB, Desruisseaux MS. Am J Pathol. 2016 Nov;186(11):2957-2969. doi: 10.1016/j.ajpath.2016.07.020. PMID: 27640146


Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies. Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. Parasitol Res. 2017 Mar;116(3):827-838. doi: 10.1007/s00436-016-5350-5. Review. PMID: 28013375


Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development. Sugi T, Ma YF, Tomita T, Murakoshi F, Eaton MS, Yakubu R, Han B, Tu V, Kato K, Kawazu S, Gupta N, Suvorova ES, White MW, Kim K, Weiss LM. MBio. 2016 May 31;7(3). pii: e00755-16. doi: 10.1128/mBio.00755-16. PMID: 27247232


An improved method for introducing site-directed point mutation into the Toxoplasma gondii genome using CRISPR/Cas9. Sugi T, Kato K, Weiss LM. Parasitol Int. 2016 Oct;65(5 Pt B):558-562. doi: 10.1016/j.parint.2016.05.002. PMID: 27167504


Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division. El Bissati K, Suvorova ES, Xiao H, Lucas O, Upadhya R, Ma Y, Angeletti RH, White MW, Weiss LM, Kim K. MBio. 2016 Feb 2;7(1):e02094-15. doi: 10.1128/mBio.02094-15. PMID: 26838719


Microsporidia - Emergent Pathogens in the Global Food Chain. Stentiford GD, Becnel JJ, Weiss LM, Keeling PJ, Didier ES, Williams BA, Bjornson S, Kent ML, Freeman MA, Brown MJ, Troemel ER, Roesel K, Sokolova Y, Snowden KF, Solter L. Trends Parasitol. 2016 Apr;32(4):336-48. doi: 10.1016/ Review. PMID: 26796229

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