Department of Orthopaedic Surgery

Highlights from 1st Annual Musculoskeletal Symposium

October 4, 2012 

Symposium brochure - Symposium Mission, Learning Objectives, Agenda, List of Faculty Members, etc. 

Click here for Photo gallery 

 

Young Investigator Award Winners 

Jonathan W. Bourne, Ph.D, Hospital for Special Surgery 

“Covalent Cross-linking Accelerates Collagen Enzyme Mechano-kinetic Cleavage: Nanomachanics Predicts Microscale Behavior” 

Michelle S. Gupta, BS, The City College of New York 

“Lower Macromer Concentration Enhances Nucleus Pulposus-like Differention and Functional Extracellular Matrix Assembly by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels”  

Da Jing, Ph.D, Columbia University 

“Ex Vivo Calcium Responses of Osteocytes and Osteoblasts in Intact Mouse Tibiae under Cyclic Mechanical Loading” 

 

Abstracts 

  1. PTH-CBD, a Long-Acting Parathyroid Hormone Analog, restores normal bone formation after cyclophosphamide therapy in mice. Ranjitha Katikaneni*, Robyn Goforth**, Robert Gensure* and Tulasi Ponnapakkam*. *Children’s Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY; **BiologicsMD, Fayetteville, AR. 
  2. Measuring musculoskeletal function and pain in rodents. Maria Gulinello, Corrina Stoddart. Behavioral Core Facility, Departments of Neuroscience, Albert Einstein College of Medicine, Bronx, NY. 
  3. Glia, gap junctions and pain: Role of sensory ganglia in tactile hypersensitivity. Regina Hanstein, Maria E. Gulinello, *Menachem Hanani, and David C. Spray. Department of Neuroscience, Albert Einstein College of Medicine, and *Laboratory of Experimental Surgery, Hadassah University Hospital, Jerusalem.   
  4. Endoplasmic Reticulum Calcium Handling in Osteocyte Mechanobiology. Genevieve Brown, Prajesh Desai, and X. Edward Guo. Department of Biomedical Engineering, Columbia University, New York, NY. 
  5. Dynamic Fluid Flow Stimulation Induced Mechanobiological Modulation of In Situ Osteocytic Ca2+ Oscillations in an Intact Mouse Femur. Minyi Hu1, Guowei Tian 2, Yi-Xian Qin1. 1Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY; 2CMIC-Two Photon Imaging Center, Stony Brook University, Stony Brook, NY. 
  6. [Ca2+]i and Actin Dynamics in Osteocytes in Intact Mouse Tibiae under Cyclic Mechanical Loading. Andrea E. Morrell*, Da Jing*, Andrew D. Baik*, and X. Edward Guo*. *Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, NY. 
  7. Elevation of Glucose to Levels Associated with Type 1 Diabetes Profoundly Diminished Bone Cell Mechanosignaling. Zeynep Seref-Ferlengez1,4, Stephanie Maung1,4, Xiaonan Wang1,4, Jelena Basta-Pljakic5, Mitchell B. Schaffler5, David C. Spray2,4, Sylvia O. Suadicani2,3,4, Mia M. Thi1,2,4. Departments of 1Orthopaedic Surgery, 2Neuroscience, 3Urology, and 4Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY; 5Department of Biomedical Engineering, City College of New York, NY. 
  8. Remodeling of Distribution of Elastic Modulus Gradients as Predictors of Early Stage Osteopenia. K. Grover, M. Hu, L. Lin, J. Jesse, Y-X. Qin. Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY. 
  9. Creep Properties of Bone and its Relation to Bone Mineral Content. Gavriel Feuer, Subrata Saha. Department of Orthopaedic Surgery and Rehabilitation Medicine, SUNY Downstate Medical Center, NY. 
  10. Local Bone Tissue Mechanical Properties Change Without Remodeling: A Study Of Lactating Mice. A. Serra Kaya, Jelena Basta-Pljakic, Zeynep Seref-Ferlengez, Wing-Yee Cheung, Robert Majeska, Susannah P. Fritton, Shoshana Yakar*, Mitchell B Schaffler. Department of Biomedical Engineering, City College of New York, NY; *New York University College of Dentistry, NY. 
  11. Characterization of Damage Mechanisms Associated with Reference Point Indentation in Human Bone. Bryan G. Beutel, Oran D. Kennedy. NYU Hospital for Joint Diseases, Department of Orthopaedic Surgery, New York, NY. 
  12. In Situ Osteocyte Modulation of β3 Integrin in Response to Hindlimb Unloading. 1Zuckerman PC, 1Laudier DM, 1Majeska RJ, 2Judex S, 1Schaffler MB. 1Department of Biomedical Engineering, City College of New York, New York, NY; 2Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY. 
  13. Sclerostin Antibody Administration Activated Bone Formation in Ovariectomized Rats with Concurrent Mechanical Unloading. D. Zhang1, M. Hu1, T. Chu1, L. Lin1, X. Li2, H.Z. Ke2, Y-X. Qin1. 1Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY; 2Metabolic Disorders Research, Amgen Inc., Thousand Oaks, CA. 
  14. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Daniel J. Leong1,2, Marwa Choudhury1,2, Regina Hanstein3, Lin Xu1,2, David M. Hirsh1, Sun Jim Kim1, Robert J. Majeska4, Mitchell B. Schaffler4, John A. Hardin1, David C. Spray3, Mary B. Goldring5, Neil J. Cobelli1, Hui B. Sun1,2. 1Departments of Orthopaedic Surgery, 2Radiation Oncology, and 3Neuroscience, Albert Einstein College of Medicine, Bronx, NY; 4Department of Biomedical Engineering, The City College of New York, New York, NY; 5Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, NY. 
  15. CITED2 mediates a novel chondroprotective pathway involving cross-talk between mechanical loading and IL-4 to suppress MMP-13. Zhiyong He1,2, Daniel J. Leong1,2, Lin Xu1,2, John A. Hardin1, Robert J. Majeska3, Mitchell B. Schaffler3, Mia M. Thi1, Luis Cardoso3, Mary B. Goldring4, Neil J. Cobelli1, Hui B. Sun1,2. 1Departments of Orthopaedic Surgery, 2Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY; 3Department of Biomedical Engineering, The City College of New York, New York, NY.  4Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, NY. 
  16. Infrapatellar fat pad (IPFP)-derived inflammatory response and articular cartilage degradation: a novel pathway for chondroprotective effects of CITED2 and exercise. Lin Xu1,2, Daniel J. Leong1,2, Zhiyong He1,2, Amanda Shuster1,2, Chantal Levy1,2, Paul Goebel1,2, John A. Hardin1, David M. Hirsh1, Robert J. Majeska3, Neil J. Cobelli1, Hui B. Sun1,2. 1Departments of Orthopaedic Surgery, 2Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY; 3Department of Biomedical Engineering, The City College of New York, New York, NY. 
  17. CITED2 is a principal regulator of telomerase expression, a representative feature of a functionally active tendon stem progenitor cell population. Fawzy A. Saad1,2, Daniel J. Leong1,2,  Zhiyong He1, Lin Xu1, Robert J. Majeska3, Tony S. Wanich1, Konrad I. Gruson1, Evan L. Flatow4, Hui B. Sun1,2. 1Departments of Orthopaedic Surgery, 2Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY; 3Department of Biomedical Engineering, The City College of New York, New York, NY; 4Department of Orthopaedics, Mount Sinai School of Medicine, NY. 
  18. Multi-level Cervical Disc Arthroplasty (CDA) versus Single-level CDA for the Treatment of Cervical Disc Diseases: A Meta-Analysis. Hua Zhao1, 2, Lei Cheng2, Lin Nie2. 1Department of Orthopaedic Surgery, Hospital for Joint Diseases, New York University, New York; 2Department of Spine Surgery, Qilu Hospital of Shandong University, Jinan, China. 
  19. Progranulin Inhibits Intervertebral Disc Degeneration in Aging Mice. Jianlu Wei, Yunpeng Zhao, Chuanju Liu. NYU Medical Center, NY. 
  20. Predicting Direction-Dependent Failure Properties of Human Trabecular Bone: Effects of Fabric Anisotropy, Poroelastic Ultrasound and Individual Trabecular Morphology. Palacio-Mancheno P.E; Moawad C; Ghatak S; Mejia M; Souzanchi M; Cowin SC; Cardoso L. The Department of Biomedical Engineering of the City College of New York, New York, NY. 
  21. Focal Injury in Pannexin 1 Knockout Mouse Yields Reduced RANKL Expression: Possible Mechanism Involving Pannexin 1 Channels for Osteoclast Recruitment? Cheung WY1, Scemes E2, Spray DC2, Basta-Pljakic J1, Schaffler MB1. 1Department of Biomedical Engineering, The City College of New York, New York, New York;  2Albert Einstein College of Medicine, Bronx, New York. 
  22. Knockdown of Heat Shock Protein 70 impairs Osteogenic Differentiation in Human Mesenchymal Stem Cell. Chenghai Li and Sihong Wang. Department of Biomedical Engineering, City College of CUNY, New York, NY. 
  23. In Vitro Growth Trajectory and In Vivo Implantation of a Cell-Based Disc-like Angle Ply Structure for Total Disc Replacement. Martin JT1,2, Ikuta K1,2, Kim DH1, Pfeifer CG1,2, Smith LJ1,2,3;  Elliott DM4, Smith HE1,2,3, Mauck RL1,2. 1Translational Musculoskeletal Research Center, Philadelphia VA Medical Center, Philadelphia, PA; 2Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA; 3Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA; 4Department of Biomedical Engineering, University of Delaware, Newark, DE. 
  24. TLR4 Inhibition Mitigates Inflammatory Induced Biophysical Changes of Nucleus Pulposus Cells. Timothy Jacobsen1, Paula Hernandez1, and Nadeen O. Chahine1. 1The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY. 
  25. Effects of Depth of Annular Injury and Tumor Necrosis Factor-alpha on Disc Degeneration and Pain. Alon Lai1, Andrew Moon1, Devina Purmessur1, Branko Skovrlj2, Beth A. Winkelstein3, Samuel K. Cho1, Andrew C. Hecht1, James C. Iatridis1. 1Leni & Peter W May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, NY; 2Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY; 3Department of Bioengineering, University of Pennsylvania, PA. 
  26. ADAMTS 18 is Important Regulator of Post-Natal Skeletal Development and Bone Remodeling. Sardar Uddin, Ben Liu, Yi-Xian Qin, Chuanju Liu. NYU Medical Center, NY. 
  27. Are Trabecular Length and Trabecular Thickness Able to Predict Fabric and Anisotropic Elastic and Inelastic Mechanical Behavior of Trabecular Bone In Compression and Shear Tests? A. De Paolis*, S. C. Cowin*, L. Cardoso*. *Department of Biomedical Engineering, The City University of New York, NY. 
  28. Regional Variations in Density and Shear Strength of Human Lumbar Vertebral Endplate and Trabecular Bone. F. Xavier, S. Hossain, R. Rousseau, N. Basu, D. Chatterjee, G. Feuer, W. Hayes, and S. Saha. Department of Orthopaedic Surgery and Rehabilitation Medicine SUNY Downstate Medical Center, NY. 
  29. Distal Tibia Bone Density and Biomechanical Strength of Interlocking Screws for Intramedullary Nails. F. Xavier, W. Hayes, A. Carrer, R. Elkhechen, and S. Saha. Department of Orthopaedic Surgery and Rehabilitation Medicine SUNY Downstate Medical Center, NY. 
  30. A New Osseointegrated TMJ Implant Design. Martin Pendola1, Gaia Salvadore2, Rehan Khan2, Subrata Saha3. 1School of Graduate Studies, SUNY Downstate Medical Center; 2NYU Poly School of Engineering; 3Department of Orthopaedic Surgery & Rehabilitation Medicine SUNY Downstate Medical Center, NY. 
  31. Injectable, Redox-Polymerized Carboxymethylcellulose Hydrogels for Stem Cell-Based Nucleus Pulposus Tissue Engineering. Varma D1; Gupta MS1; Gold G1; Nicoll SB1. 1Department of Biomedical Engineering, The City College of New York, New York, NY. 
  32. Contrast-Enhanced µCT Arthrography (CE-µCTA) of Hard and Soft Tissues in Mice Knee Joints. Cardoso L1, Leong DJ2, & Sun HB2. 1Department of Biomedical Engineering, The City College of New York; 2Albert Einstein College of Medicine, Bronx, NY. 
  33. Effects of Mild Heating on the Osteogenesis of Mesenchymal Stem Cells During Inflammation. Kristifor Sunderic, Dionne Dawkins, Sihong Wang. Department of Biomedical Engineering, The City College of New York, NY. 
  34. Thermal Regulation of Human Mesenchmal Stem Cell Differentiation Toward Bone and Cartilage Lineages. Jing Chen, Chenghai Li and Sihong Wang. Department of Biomedical Engineering, City University of New York/City College, New York, NY. 
  35. Minimally Invasive Stereotactic Separation Surgery for Resection of Metastatic Spine Lesion: A Feasibility Study. 1Rani Nasser, 2Saankritya Ayan,  2Alok Sharan, 1Reza Yassari. Departments of 1Neurosurgery and 2Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY. 
  36. Regulation of PTH-induced Bone Loss: A Role for Monocyte Chemoattractant Protein-1.  Jawed Siddiqui1, Joshua Johnson1, Joseph Tamasi2, Nicola Partridge1. 1New York University College of Dentistry, USA, 2Bristol-Myers Squibb, USA. 
  37. Utilizing Cell Surface Markers to Define the Stages of Osteoblast Differentiation. Pratistha Koirala, Vincent I. Poon, Michael Roth, Sajida Piperdi, Jonathan Gill, and Richard Gorlick. Albert Einstein College of Medicine,Bronx, NY; Montefiore Medical Center, Bronx, NY. 

 

 

 

 

Chair:

Neil J. Cobelli, M.D.
neil.cobelli@einstein.yu.edu
Tel: 347.577.4450
Fax: 347.577.4451

Administrator

Anna Cioffi
anna.cioffi@einstein.yu.edu
Tel: 718.430.2911

 

Department Office

Montefiore Medical Center
1250 Waters Place
11th floor
Bronx, NY 10461

Tel: 347.577.4450
Fax:
347.577.4451

 
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