Grant Award: Dr. Kamran Khodakhah

Friday, November 17, 2017

Kamran Khodakhah, Ph.D., has received a five-year, $3.6 million grant from the National Institute on Drug Abuse to expand on his earlier research linking the cerebellum to the ventral tegmental area (VTA), a brain region involved in addiction and other reward-seeking behaviors. He and his colleagues will use anatomical and physiological approaches to find the neural pathways by which the cerebellum can affect the VTA as well as two other regions associated with addiction: the prefrontal cortex and the nucleus accumbens. Dr. Khodakhah is professor and chair of the Dominick P. Purpura Department of Neuroscience and the Florence and Irving Rubinstein Chair in Neuroscience. (1R01DA044761-01A1)

News: Renata Batista-Brito: Next Generation Leaders Council

Monday, November 13, 2017

We are pleased to announce that incoming faculty member Dr. Renata Batista-Brito has been selected to be a Next Generation Leader council member for the Allen Institute.

Grant Award: Dr. Julie Secombe

Wednesday, October 18, 2017

The National Institute on Aging has awarded Julie Secombe, Ph.D., a five-year, $1.69 million grant to study whether transposons influence aging. So far, research on transposons and aging has been limited by available techniques. Dr. Secombe and her team will use novel methods to analyze the genomes of single cells. They will also focus on the role of Myc, a transcription factor (i.e., a protein regulating gene expression) known to affect aging in model organisms. By determining interconnections among Myc transposons that contribute to aging, the team may develop strategies for suppressing this activity and, ultimately, improve human longevity. Dr. Secombe is associate professor of genetics and is associate professor in the Dominick P. Purpura Department of Neuroscience. (1R01AG053269-01A1)

Grant Award: BRAIN Initiative - Dr. Jose Pena

Monday, October 16, 2017

Dr. Jose Pena and collaborators were awarded a BRAIN award for the following project: "From Microscale Structure to Population Coding of Normal and Learned Behavior."

Publication: Dr. Steve Walkley

Monday, October 02, 2017

Steven Walkley, D.V.M., Ph.D., has co-authored a study in the August 10 issue of The Lancet showing that the drug 2-hydroxypropyl-β-cyclodextrin (HPβCD) can safely slow NPC1's progression. Patients received monthly or bi-weekly spinal injections of the drug for 18 months. Following the treatment period, biochemical and neurological tests showed that, compared with historical data for patients the same age, patients treated with the drug experienced significantly less cognitive dysfunction, with minimal side effects. Dr. Walkley is director of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center and professor in the Dominick P. Purpura Department of Neuroscience, in the department of pathology, and in the Saul R. Korey Department of Neurology at Einstein.

Publication: Dr. Pablo Castillo

Wednesday, September 20, 2017

Pablo Castillo, M.D., Ph.D., and colleagues identified a novel form of LTP in which synaptic strengthening depends on the presynaptic neuron (which releases the neurotransmitter into the synapse) rather than on the postsynaptic neuron (which receives the neurotransmitter). This form of LTP may be involved in learning as well as the neuronal excitation that causes temporal lobe epilepsy. The researchers reported their findings online on August 16 in Neuron. Dr. Castillo is professor in the Dominick P. Purpura Department of Neuroscience and of psychiatry and behavioral sciences, as well as the Harold and Muriel Block Chair in Neuroscience.

Grant Award: Dr. Noboru Hiroi

Wednesday, September 13, 2017

Noboru Hiroi, Ph.D., has been awarded a five-year, $1.8 million grant from the National Institute on Deafness and Other Communication Disorders to investigate the interplay among genes, early social communication and neonatal maternal care in determining the severity of autism spectrum disorder (ASD). Working with a genetic mouse model of ASD, Dr. Hiroi’s lab has observed that newborn mice display an unusual vocalization or “call,” to communicate with their mothers and that this abnormal call reduces the level of maternal care that newborns receive. The researchers will study whether abnormal newborn-to-mother vocalization is caused by ASD-related gene variants and whether this early experience of social communication gone awry worsens ASD-like behaviors through the epigenetic modification of these gene variants. Dr. Hiroi is professor in the Dominick P. Purpura Department of Neuroscience and of psychiatry and behavioral sciences. (1R01DC015776-01A1)

Grant Award: Dr. Scott Emmons

Thursday, March 23, 2017

The National Institute of Mental Health has awarded Scott W. Emmons, Ph.D., a five-year, $2 million grant to investigate the synaptic connections that allow signals to travel from neuron to neuron throughout the brain. The researchers will conduct their studies on the nematode worm Caenorhabditis elegans, which depends on genes similar to those that lay down the neuronal architecture in human brains. Through a combination of genetic, molecular and biochemical studies, the research should shed light on the function of these genes and the factors that make accurate nerve connectivity possible. Dr. Emmons is professor of genetics and of neuroscience and holds the Siegfried Ullmann Chair in Molecular Genetics. (1R01MH112689-01)

Publication: Dr. Kamran Khodakhah

Wednesday, February 15, 2017

New Target For Dystonia Therapy—Dystonia—when someone’s muscles contract uncontrollably—is the third most common movement disorder (after Parkinson’s and essential tremor), affecting about 250,000 Americans. Research and treatment for the most common inherited form of dystonia, called DYT1, has focused mainly on the basal ganglia region of the brain. But new animal research by Einstein scientists implicates a different part of the brainthe cerebellumas the site of the problem. The study, published in the February 15 online issue of eLife, was led by Kamran Khodakhah, Ph.D., professor and chair of the Dominick P. Purpura Department of Neuroscience and the Harold and Muriel Block Chair in Neuroscience. He and his colleagues made their discovery after generating the first mouse model of DYT1 to exhibit the overt symptoms of dystonia seen in patients. Previous research in Dr. Khodakhah’s lab has shown that severing the link between the cerebellum and the basal ganglia might be an effective way to treat cerebellar-induced dystonias.

Grant Award: Dr. Elyse Sussman - ASHA awards

Thursday, August 04, 2016

Dr. Elyse Sussman and graduate student Renee Symonds are recent recipients of a number of awards and honors by the American Speech-Language-Hearing Association (ASHA). Dr. Sussman and Renee Symonds received a Research Mentoring-Pair Travel Award (RMPTA) while Ms. Symonds also received both an Audiology/Hearing Science Research Travel Award (ARTA) and a Student Research Travel Award (SRTA) for recent work, entitled "The Impact of Unattended Auditory Cues on Perception & Task Performance in Complex Auditory Environments." This poster, and the work contained therein, was judged and found to be superlative, being only one of 48, out of over 1900 posters submitted, to earn the "Meritorious Poster" qualification by the ASHA.

Grant Award: Dr. Hiroi - CINP Lilly Neuroscience Basic Research Award

Sunday, July 03, 2016

We are pleased to announce that Dr. Noboru Hiroi was awarded the 2016 Lilly Neuroscience Basic Research Award by the International College of Neuropsychopharmacology (CINP). Dr. Hiroi will be honored at the opening ceremony of the CINP congress held in Seoul, Korea July 3-5th, 2016

Grant Award: 2016 Junior Investigator Neurosci. Research Awards

Friday, July 01, 2016

We are pleased to announce that the 2016 JINRA awardees are Randy Stout from the Spray Lab and Steven Cook & Leo Tang respectively from the Emmons and Buelow Labs. For more information about the JINRA program, please see the recent About Campus feature article.

Publication: Dr. Vytas Verselis

Monday, June 27, 2016

Dr. Vytas Verselis and collaborators recently published Sanchez HA, Slavi N, Srinivas M and Verselis, VK. Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. J Gen Physiol. 148(1): 25-42, 2016. The work was also featured in a recent EurekAlert news release detailing variation in the symptoms of patients afflicated with keratitis-ichthyosis-deafness (KID) syndrome.

News: Neuroscience Chair: Dr. Kamran Khodakhah

Tuesday, May 10, 2016

We are pleased to announce that Dr. Kamran Khodakhah was recently appointed to chair of the Dominick P. Purpura Department of Neuroscience. Full press release is available here.

News: 10th Annual Horwitz Faculty Prize: Dr. Scott W. Emmons

Monday, February 29, 2016

Dr. Scott W. Emmons, professor in the Dominick P. Purpura Department of Neuroscience, is the Tenth Annual recipient of the Marshall S. Horwitz, M.D., Faculty Prize for Research Excellence.

Publication: Dr. Feliksas Bukauskas

Monday, February 15, 2016

Dr. Feliksas Bukauskas and collaborators recently published Maciunas K, Snipas M, Paulauskas N and Bukauskas, FF. Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels. J Gen Physiol. 147(3): 273-88, 2016. Their work was also featured on the cover of the journal.

Publication: Drs. Scott Emmons and David Hall

Thursday, October 15, 2015

Drs. Scott EmmonsDavid Hall and colleagues have co-authored a feature article for the upcoming "Neuro Special" issue of Nature, Sammut et al. “Glia-derived neurons are required for sex-specific learning in C. elegans.”

News: Dystonia Medical Research Foundation Bronx Zoo Walk

Sunday, October 04, 2015

Members, friends and family of the Neuroscience Department will be walking and fundraising in the Dystance4Dystonia Bronx Zoo Walk, being held on October 4th, 2015 at the Bronx Zoo. Participants should enter via the Southern Blvd gate. Registration begins at 8:00AM, while the event begins at 9:30AM. For more information about Dystonia, click here.

Publication: Dr. Randy Stout Jr.

Tuesday, August 11, 2015

Dr. Randy Stout Jr (of the Dr. David Spray lab) and collaborators recently published Connexin Type and Fluorescent Protein-fusion Tag Determine Structural Stability of Gap Junction Plaques. J Biol Chem. [Epub ahead of print], 2015.

Publication: Dr. Matthew Klein

Tuesday, March 03, 2015

Dr. Matthew Klein (of the Dr. Pablo Castillo and Dr. Bryen Jordan labs) and collaborators recently published Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD. Cell Rep. S2211-1247(15)00166-7 [Epub ahead of print] which was highlighted by the Faculty of 1000.

Media: Fanny Cazettes

Friday, February 20, 2015

Fanny Cazettes, a graduate student in the Pena lab was recently interviewed in eLife discussing "Decoding Behaviour." Fanny Cazettes and collaborators had recently published with eLife for Spatial cue reliability drives frequency tuning in the barn Owl''s midbrain.

Publication: Dr. Ted Bargiello

Thursday, January 01, 2015

Dr. Ted Bargiello and a collaborator published the following review: Oh S, Bargiello TA. Voltage Regulation of Connexin Channel Conductance. Yonsei Med J. 56(1):1-15, 2015.

Publication: Dr. Jose Luis Pena

Monday, December 22, 2014

Dr. Jose Luis Pena and collaborators published the following paper: Cazettes F, Fischer BJ, Pena JL. Spatial cue reliability drives frequency tuning in the Barn Owl's midbrain. Elife. [Epub ahead of print], 2014

Publication: Dr. Kamran Khodakhah

Monday, December 01, 2014

Dr. Kamran Khodakhah and collaborators published the following paper: Chen CH, Fremont R, Arteaga-Bracho EE, Khodakhah K. Short latency cerebellar modulation of the basal ganglia. Nat Neurosci. 17(12):1767-75, 2014.

Grant Award: Dr. Yonatan Fishman

Monday, December 01, 2014

Dr. Yonatan Fishman was awarded an NIH multi-PI grant R01DC013961 with co-investigator Dr. Yale Cohen (University of Pennsylvania). The project examines neural bases of auditory scene analysis in behaving non-human primates.

Publication: Dr. David Spray

Friday, November 21, 2014

Dr. David Spray and a collaborator published the following editorial: Zoidl G, Spray DC. Gap junctional communication in health and disease. Front Physiol. 5:442, 2014.

Publication: Dr. Adam Kohn

Wednesday, November 19, 2014

Dr. Adam Kohn and collaborators published the following paper: Czuba TB, Huk AC, Cormack LK, Kohn A. Area MT Encodes Three-Dimensional Motion. J Neurosci. 34(47):15522-33, 2014.

Publication: Dr. Florence Marlow

Saturday, November 15, 2014

Dr. Florence Marlow and collaborators published the following paper: Feng L, Jiang H, Wu P, Marlow FL. Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish. Dev Biol. 395(2):268-86, 2014.

Publication: Dr. Adam Kohn

Monday, October 20, 2014

Dr. Adam Kohn and collaborators published the following paper: Solomon SG, Kohn A. Moving Sensory Adaptation beyond Suppressive Effects in Single Neurons. Curr Biol. 24(20):R1012-R1022, 2014.

Publication: Dr. Saleem Nicola

Wednesday, October 15, 2014

Dr. Saleem Nicola and a collaborator published the following paper: Morrison SE, Nicola SM. Neurons in the nucleus accumbens promote selection bias for nearer objects. J Neurosci. 34(42):14147-62, 2014.

Publication: Dr. Florence Marlow

Wednesday, October 01, 2014

Dr. Florence Marlow and collaborators published the following paper: Hartung O, Forbes MM, Marlow FL. Zebrafish vasa is required for germ-cell differentiation and maintenance. Mol Reprod Dev. 81(10):946-61, 2014.