Frank Soldner, MD
Dr. Soldner will join the Einstein faculty as Assistant Professor in the department of Neuroscience in January 2019. His research focuses on modeling human brain development and function in a cell culture dish as a tool to understand the molecular and cellular basis of complex neurological disorders such as Alzheimer’s and Parkinson’s disease. Dr. Soldner received his MD degree from the University of Tübingen in Germany. In his thesis work under the guidance of Jörg Schulz, he investigated the molecular mechanism of cellular death in dopaminergic neurons as a model of Parkinson’s disease. He went on to conduct his postdoctoral research with Ron McKay at the National Institute of Neurological Disorders and Stroke and Rudolf Jaenisch at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology where he established novel experimental paradigms in human pluripotent stem cell-derived neuronal cells to dissect the genetic basis of Parkinson’s disease. His work demonstrated, that integration of population genetic and genome-scale epigenetic data combined with human pluripotent stem cells and gene editing technologies now provides a realistic opportunity to study complex neurological disorders in a genetically controlled and systematic manner.
Dr. Soldner’s research at Einstein will be focused on applying novel functional genomic approaches in human neuronal cells to investigate how genetic, epigenetic and environmental factors are integrated to contribute to development and progression of neurodegenerative diseases.