Molecular and Cellular Neuroscience
Dr. Kamran Khodakhah
Credits/Class Meetings: 5 semester hours in the form of three 2 hour meetings per week for a total of approximately 45 presentations. A number of lectures may be devoted to invited speakers from outside the Medical School, and presentations by the students.
Suitability for 1st Year Students: First year students and MSTP are encouraged.
Suggested Background Reading: "Principles of Neuroscience" by Kandel and Schwartz and Jessell, and "From Neuron to Brain: A Cellular and Molecular Approach to the Function of the Nervous System"(4th Edition) by A. Robert Martin, Bruce G. Wallace, Paul A. Fuchs, John G. Nicholls
Course Description: The course offers a multidisciplinary approach to the study of the nervous system. The class format consists of a combination of formal and informal lectures together with student presentations. A major emphasis is made on interactive class discussion. The course is demanding and requires active student participation during the class.
Dr. Mark Mehler
Dr. Zaven Kaprielian
Credits/Class Meetings: 5 semester hours/three 1.5 hour meetings per week for a total of approximately 37 classes.
Prerequisite Background: Undergraduate courses in Developmental Biology, Molecular Genetics and Neuroscience are recommended but not required.
Suggested Background Reading: Fundamental Neuroscience, Zigmond et al.,; Principles of Neuroscience, Kandel and Schwartz.
Suitability for 1st Year Students: Recommended for 1st year students.
Course Description: This course will cover the cellular and molecular principles underlying the construction of a functioning nervous system. The course will begin with overviews of neurogenesis, neural patterning and axon guidance, and an introduction to neuroembryology. Subsequent classes will focus on neural induction, patterning of the neuraxis, stem cell biology, growth factors/cytokines and relevant signaling mechanisms, neurogenesis and gliogenesis, forebrain development, neuronal cell death, axon guidance mechanisms, synapse assembly and neural circuit formation. Throughout the course, insights gained from both vertebrate and invertebrate model systems will be discussed.
Grading will be based on participation in course director-facilitated Student Synopsis and Discussion classes and Student Study Sections, as well as on a written Grant Proposal. There are eight Student Synopsis and Discussion classes interspersed with faculty lectures. During these classes, students are expected to summarize the main points of the preceding two or three lectures, as well as present and discuss key papers in these areas. Each student in the class will be required to write an original grant proposal on a topic in Developmental Neuroscience. There will be two Student Study Sections during the semester. At these study sections, students will critique their classmates’ grant proposals. After each study section, students will have the opportunity to revise their grant proposal based on the recommendations of their peers. The final revision of the grant proposal will be turned in on the last day of class in lieu of a final exam and will be graded by the course directors.
Dr. Jose Luis Pena
Dr. Adam Kohn
Dr. Odelia Schwartz
Credits/Class Meetings:5 credits/three 1.5 hour meetings per week for a total of approximately 30 class sessions
Prerequisite Background: You must have completed and passed the Cellular and Molecular Neuroscience course (special cases should contact course leaders).
Suggested Background Reading:Principles of Neural Science (Kandel, Schwartz & Jessell, Eds.), The Cognitive Neurosciences III (Gazzaniga, Ed.), Theoretical Neuroscience (Dayan & Abbott, Eds.).
Suitability for 1st Year Students: Suitable for 1st year students.
Scope:The course will explore how complex neural systems integrate afferent information and direct efferent outflow. The overall goal will be to explore higher order functions, such as the structure and function of neural systems underlying sensation and movement, learning and memory at the sensory and motor levels, as well as higher-level cognitive processes including object perception and attention. At every stage we will build on a firm understanding of the underlying physiology and anatomical structure. Principal areas of interest will be on hierarchical neural systems, the plasticity of neural networks, serial and parallel neural processing, cognition and computational modeling.
Format: The course will be divided into four modules: 1) Principles of neural systems, 2) Neural bases of sensation 3) Neural bases of behavior and 4) Higher order functions and cognition. Each module will contain an initial series of didactic lectures introducing key facts and concepts, as well as class participation sessions focused on pre-assigned questions and relevant research papers. Techniques will be illustrated by demonstration.
Grading: The grade will be based on class participation and a term paper in the form of a grant proposal. The midterm exam will involve critiquing classmates’ grant proposals.
Neuroanatomy: Basic and Applied
Dr. Adam Kohn
Credits/Class Meetings: A short course offered at the beginning of each Spring semester, 2 semester hours, 18 sessions including 4 laboratory sessions and a practical exam.
Prerequisite Background: An undergraduate course in Neuroscience is recommended but not required.
Suggested Background Reading: Martin, J.H., Neuroanatomy Text and Atlas, Appleton and Lange, 1996
Suitability for 1st Year Students: Recommended for 1st Year Students
Course Description: Basic and applied neuroanatomy is a hands-on interactive course designed to acquaint the student with central nervous system neuroanatomy. "Applied" in this course means research applications rather than clinical, although clinical questions are used for learning purposes. Brain function will be divided into systems such as motor control, sensory processing, and learning and memory. Each system and the associated brain structures will be introduced with a didactic lecture followed by identification of the involved structures from student brain dissections. Practical techniques including the use of microscopes, anatomic tracers, and drawing programs will be discussed and demonstrated.
The course will consist of 2 lectures and a practical lab each week. The grade will be based on two practical exams where students will identify anatomical structures and respond to essay questions.