Spotlight

Dominick P. Purpura Department of Neuroscience

Animal Behavior Core

Go to the Behavioral Core Website 

     The Behavioral Core provides expertise, staff and state-of-the-art equipment and software designed for testing behavioral outcome in rodents. The Core also maintains the strictest standards with regards to validity and reliability of behavioral assays andtraining. We facilitate functional assessments and phenotyping with many type of logistical support including help with animal protocols, grant and manuscript writing, experimental design and statistical analysis. We have many well-characterized assays, and we also develop tests to suit individual needs and other species.

Contact: Maria Gulinello, Ph.D
Kennedy 925, B32, B34
tel. 718-430-4042

Cognitive Function
  • Visual Working Memory - Object Recognition
  • Spatial Working Memory -Object Placement
  • Social Discrimination Memory
  • Spontaneous Alternation
  • Morris Water Maze
  • Radial Arm Maze (reference and working memory)
  • Conditioned Taste Aversion

Affective / Emotional Behaviors
  • Social Interaction Social Preference
  • Social Transmission of Food Preferences
  • Reproductive and mating behavior
  • Open Field (exploratory behavior, risk assessment, thigmotaxis)
  • Marble Burying (neophobia, compulsions)
  • Elevated Plus Maze (anxiety)
  • Light/Dark Box (anxiety)
  • Acoustic Startle – anxiety and hearing
  • Porsolt (Forced Swim) Test – depression
 
Tests of Analgesia
  • Von Frey (sensory threshold and allodynia)

Sensorimotor Function
  • Open Field (activity, habituation, sensitization)
  • Rotarod (motor coordination, motor learning)
  • Grip Strength (sensorimotor function, muscle strength)
  • Gait analysis and toe spread (motor coordination)
  • Balance Beam (motor coordination)
  • Visual Placing (visual acuity)
  • Visual Cliff (visual acuity and depth perception)
  • Pupil dilation
  • Acoustic Startle and Prepulse Inhibition

Other
  • Functional Observation Battery (Primary Screen)
  • Estrous Cycle Staging
  • Ultrasonic vocalizations (coming soon)
  • Behavioral Tracking software (Viewer, Biobserve)
  • Conditioned Place Preferences and Aversions
  • Grooming
  • Stereotypies
  • Developmental milestones
 
 
 

Recent News & Events

Publication | Dr. Kamran Khodakhah
New Target For Dystonia Therapy—Dystonia—when someone’s muscles contract uncontrollably—is the third most common movement disorder (after Parkinson’s and essential tremor), affecting about 250,000 Americans. Research and treatment for the most common inherited form of dystonia, called DYT1, has focused mainly on the basal ganglia region of the brain. But new animal research by Einstein scientists implicates a different part of the brainthe cerebellumas the site of the problem. The study, published in the February 15 online issue of eLife, was led by Kamran Khodakhah, Ph.D., professor and chair of the Dominick P. Purpura Department of Neuroscience and the Harold and Muriel Block Chair in Neuroscience. He and his colleagues made their discovery after generating the first mouse model of DYT1 to exhibit the overt symptoms of dystonia seen in patients. Previous research in Dr. Khodakhah’s lab has shown that severing the link between the cerebellum and the basal ganglia might be an effective way to treat cerebellar-induced dystonias....more

more news and events

 

Contact Us

Rose F. Kennedy Center

1410 Pelham Parkway South

9th Floor

Bronx, NY 10461

Phone: 718-430-2408

Fax: 718-430-8821

 
 
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