Dominick P. Purpura Department of Neuroscience

Core/Shared Facilities

The Dominick P. Purpura Department of Neuroscience maintains two research facilities that are available, at minimal charge, for use by all department members, as well as by members of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center. Both cores provide instruction in the use of the facilities, assistance with the actual experiments and guidance in experimental design.

One facility is the Animal Behavior Core, which has the equipment required for the quantitative assessment of rodent behavior in tests of cognition, sensorimotor performance, and affective function.

The other facility is the Cellular and Molecular Imaging Core, which provides access to a wide range of imaging techniques, including confocal microscopy, two-photon laser microscopy, electron microscopy and laser capture, as well as expertise in image processing and presentation.

To further compliment in-house lab equipment, the Kennedy Center Cellular and Molecular Shared Equipment Facility on the third floor, provides additional common experiment equipment (including western blot and gel scanners, scintillation counter, film developer and various shakers and centrifuges).

Recent News & Events

Publication | Dr. Steve Walkley
Steven Walkley, D.V.M., Ph.D., has co-authored a study in the August 10 issue of The Lancet showing that the drug 2-hydroxypropyl-β-cyclodextrin (HPβCD) can safely slow NPC1's progression. Patients received monthly or bi-weekly spinal injections of the drug for 18 months. Following the treatment period, biochemical and neurological tests showed that, compared with historical data for patients the same age, patients treated with the drug experienced significantly less cognitive dysfunction, with minimal side effects. Dr. Walkley is director of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center and professor in the Dominick P. Purpura Department of Neuroscience, in the department of pathology, and in the Saul R. Korey Department of Neurology at Einstein....more

Publication | Dr. Pablo Castillo
Pablo Castillo, M.D., Ph.D., and colleagues identified a novel form of LTP in which synaptic strengthening depends on the presynaptic neuron (which releases the neurotransmitter into the synapse) rather than on the postsynaptic neuron (which receives the neurotransmitter). This form of LTP may be involved in learning as well as the neuronal excitation that causes temporal lobe epilepsy. The researchers reported their findings online on August 16 in Neuron. Dr. Castillo is professor in the Dominick P. Purpura Department of Neuroscience and of psychiatry and behavioral sciences, as well as the Harold and Muriel Block Chair in Neuroscience....more

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Contact Us

Rose F. Kennedy Center

1410 Pelham Parkway South

9th Floor

Bronx, NY 10461

Phone: 718-430-2408

Fax: 718-430-8821

 
 
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