10/10 – 10/11
Principal Investigator: R. Holtzer
The Paced Auditory Serial Addition Test (PASAT) and Symbol Digit Modalities Test (SDMT) are commonly used to assess cognitive status and decline in patients with Multiple Sclerosis (MS). However, whether these tests can serve as primary outcomes in MS clinical trials has not been determined. This proposal is designed to achieve the following specific aims: 1. To identify separate cognitive trajectories on the PASAT and SDMT within one session and over two additional monthly follow-up assessments. 2. To examine whether separate cognitive trajectories on the PASAT and SDMT are related to disease status and functional outcomes in MS.
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