Forchheimer Building 223
Associate Professor, Department of Molecular Pharmacology
The long term goal of this research program is to understand the molecular mechanisms of cell growth and differentiation, and their relationships to human disease. We focus on elucidating the interplays between transcription factors and signaling pathways. We ask how does extracellular stimuli communicate with intracellular effectors, and eventually modulate cellular responses in normal and diseased states.
We use transcription factor NFAT as a pivotal point in the research program because of their expression in numerous tissues, and their intricate regulation by protein kinases and phosphatases. In addition, NFAT is only found in vertebrates, suggesting its unique role in higher eukaryotes. The major question of this research program is : What is the regulation and function of NFAT ? This laboratory utilizes molecular biology, biochemistry, and transgenic animals to investigate the physiological functions and regulations of transcription factor NFAT.
 Yang, T.C., Davis, R.J. and Chow, C.W. (2001) Requirement of two NFATc4 transactivation domains for CBP potentiation. J. Biol. Chem. 276, 39569-39576.
 Yang, T.C., Xiong, Q., Enslen, H., Davis, R.J. and Chow, C.W. (2002) Phosphorylation of NFATc4 by p38 mitogen-activated kinases. Mol. Cell. Biol. 22, 3892-3904.
 Yang, T.C. and Chow, C.W. (2003) Transcription cooperation by NFAT:C/EBP composite enhancer complex. J. Biol. Chem 278,15874-15885.
 Schubert, W., Yang, X.Y., Yang, T.C., Factor, S.M., Lisanti, M.P., Molkentin, J.D., Rincon, M. and Chow, C.W. (2003) Requirement of transcription factor NFAT in developing atrial myocardium. J. Cell. Biol. 161, 861-874.
 Yang, T.C., Xiong, Q., I.A. Graef, G.R. Crabtree, and Chow, C.W. (2004) Recruitment of the ERK/RSK signaling pathway to NFATc4 transcription activation complex. Mol. Cell. Biol. In press.