Einstein/Montefiore Department of Medicine

About: History: Faculty Research: Hematology

About: History

Faculty Research:Hematology

In Hematology, Irving London’s laboratory, including Ernst Jaffé and Bert Lowy, assisted by Grace Vanderhoff, Gertie Neumann, and Halina Morell, conducted studies on the biosynthesis of hemoglobin and the metabolism of erythrocytes.

One of the other early fellows in the London laboratory was Bracha Ramot, a visitor from Israel, who went on to become the “doyenne of Israeli hematology.”

Tim Hunt, a post-doctoral fellow in that laboratory in the late 1960s, went on to share a Nobel Prize in 2001 for his studies of the cell cycle.

Helen Ranney developed a major laboratory and clinical center to study hereditary disorders of hemoglobin, especially sickle cell disease, and trained a series of research fellows including Robert Bookchin and Ronald Nagel. Dr. Bookchin, with Paul Gallop (of Biochemistry, who later moved to Harvard), reported one of the earliest studies of hemoglobin A1c, and Drs. Ranney and Blumenfeld (also of Biochemistry), then described its abnormalities in patients with diabetes. Dr. Bookchin and Dr. Nagel have made major contributions to our understanding of the pathologic physiology of hemoglobinopathies and their treatment. Dr. Nagel now directs the Hematology Division, an NIH-funded Sickle Cell Disease Center, and also a research program aiming at gene therapy of hemoglobinopathies, the last fittingly in collaboration with Dr. London’s laboratory, which is now at MIT.

Philip Aisen, an AECOM fellow from 1957 to 1958 in Herb Scheinberg’s laboratory, has conducted long-term studies of the biophysics of iron metabolism and transferrin.

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