In Gastroenterology, Irwin Arias, after his original delineation of the biochemical defect in Gilbert’s disease, went on to elucidate the pathophysiology of several other types of hereditary jaundice, including Dubin Johnson and Rotor syndromes.
That work was later extended by Jayanta and Namita Roy-Chowdhury, who further elucidated the enzyme reactions responsible for the glucuronidation of bilirubin, and then turned their attention to the possible correction of those and other hereditary metabolic abnormalities of hepatic function by transplantation.
David Shafritz, the Director of AECOM’s Liver Research Center, performed seminal studies of hepatic protein synthesis and of viral hepatitis and hepatoma.
Kiron Das, who went on to direct the Gastrointestinal Division at the Robert Wood Johnson School of Medicine in New Jersey, defined some of the immunologic abnormalities in patients with inflammatory bowel disorders.
In recent years, Douglas Simon, working mainly at Jacobi, has studied enteric disorders in patients with Acquired Immune Deficiency Syndrome (AIDS), and has undertaken trials to attempt to treat the diarrheal disorders.