Genetics of Rheumatoid Arthritis and Autoimmunity: New Pathways, New Concepts
Image: Peter K. Gregersen, MD
Einstein-Montefiore Department of Medicine Grand Rounds
Thursday, February 19, 2009
First Floor Lecture Hall, Forchheimer/Einstein
Cherkasky Auditorium/Montefiore Medical Center
Peter K. Gregersen, MD
Investigator Head, Robert S. Boas Center for Genomics & Human Genetics
Director, Eileen Ludwig Greenland Center for Rheumatoid Arthritis
Professor of Medicine and Pathology, New York University School Of Medicine
Rheumatoid arthritis (RA) and related autoimmune disorders such as systemic lupus, type 1 diabetes, and inflammatory bowel disease affect nearly 5 percent of the U.S. population.
Dr. Peter K. Gregersen is internationally recognized as a leading investigator in the genetics of autoimmune disorders. Over the past decade, he has directed the world’s largest effort to identify the genes underlying RA. In 2004, Gregersen and colleagues identified PTPN22, the first major gene that confers risk for multiple autoimmune diseases—a discovery that provided direct evidence that diverse forms of autoimmune disease are actually related genetically. Definitive evidence for the existence of additional risk genes for RA emerged from Gregersen’s laboratory in 2006. He and his team are now in the process of identifying these genes.
Dr. Gregersen consults and collaborates widely with other groups working on diseases with a complex genetic basis. His laboratory has led the development of robotic and computer software solutions for high-throughput genetic mapping in the New York metropolitan area, and is currently able to produce 20 million genotypes per day. Working with the Inflammatory Bowel Disease Genetics Consortium, Gregersen's laboratory helped to identify a major new gene for Crohn’s disease in late 2006.
Gregersen has other genetic mapping projects under way with international collaborators, particularly at the Karolinska Institute in Stockholm, as well as within the Feinstein Institute for Medical Research and with investigators at Cold Spring Harbor Laboratory.
Medical Grand Rounds this week is sponsored by the Division of Rheumatology.
Albert Einstein College of Medicine designates this educational activity for a maximum of 1 credit towards the AMA Physician’s Recognition Award. Each physician should claim only those credits that he/she actually spent in the educational activity.
Albert Einstein College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.