Cholangiocytes, Cilia and Cysts: What's the Connection?
Einstein-Montefiore Department of Medicine Grand Rounds
Thursday, November 20, 2008
First Floor Lecture Hall, Forchheimer/Einstein
Cherkasky Auditorium/Montefiore Medical Center
Nicholas F. LaRusso, MD
Director, Center for Innovation
Distinguished Investigator of The Mayo Foundation
Charles H. Weinman Endowed Professor of Medicine
Mayo Clinic, Rochester, MN
Medical Grand Rounds this week is sponsored by the Division of Hepatology and will be presented by Dr. Nicholas F. LaRusso of the Mayo Clinic.
Dr. LaRusso is the Charles H. Weinman Endowed Professor of Medicine, Director of the Center for Innovation at Mayo Clinic, and a Distinguished Investigator of the Mayo Foundation.
Dr. LaRusso's research applies the technologies of cell/molecular biology to understand hepatic epithelial cell function and dysfunction. His lab's primary focus is on cholangiocytes (epithelial cells that line intrahepatic bile ducts). His research has recently shown that:
- aquaporins (AQPs), a family of water channels, are important in ductal bile formation
- cholangiocytes contain primary cilia that act as sensory organelles and participate in normal bile formation and in biliary cystogenesis
Prior to becoming Center Director in 2008, he held positions as Vice Chair for Research of the Department of Medicine, Chair of the Division of Gastroenterology and Hepatology, and Chair of the Department of Medicine, all at Mayo Clinic.
He received his undergraduate degree (magna cum laude) from Boston College, his M.D. degree from New York Medical College, and his training in internal medicine and gastroenterology at Mayo, the latter as an NIH fellow in the laboratory of Alan Hofmann.
Before assuming a faculty position at Mayo in 1977, he was a guest investigator at the Rockefeller University in the laboratory of the Noble laureate, Christian de Duve. A member of the American Association of Clinical Investigation and the Association of American Physicians, he is the former editor of GASTROENTEROLOGY and past president of the American Association for the Study of Liver Diseases (AASLD) and the American Gastroenterological Association (AGA). Among other honors, he is a recipient of a MERIT Award and the Principle Investigator on two R01s from the NIH; he also received Distinguished Achievement Awards from both the AGA and the AASLD, and the Distinguished Mentor award from the AGA. He is currently past president of the AGA.
After attending this activity, participants will be able to:
- Understand the physiologic and pathophysiologic relevance of cholangiocytes (biliary epithelia)
- Understand the functional role of cholangiocytes and cilia in normal and abnormal physiology
- Understand concepts regarding the molecular mechanisms of cystic liver disease
Albert Einstein College of Medicine designates this educational activity for a maximum of 1 credit towards the AMA Physician’s Recognition Award. Each physician should claim only those credits that he/she actually spent in the educational activity.
Albert Einstein College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.