Dr. Schuster received his M.D. at Washington University, St. Louis in 1977. He was an intern, resident, and chief resident in Internal Medicine at the University of Washington, Seattle (Robert G. Petersdorf and Philip Fialkow, chairs) and a renal fellow at Southwestern Medical School, Dallas (Harry Jacobson, lab director; Donald W. Seldin, chair).
His first faculty position was at the University of Iowa, Iowa City (Francois Abboud, chair). In 1988, he moved to the Albert Einstein College of Medicine in the Bronx (James Scheuer, chair) where is currently Professor of Medicine and of Physiology & Biophysics.
Dr. Schuster became chief of the Einstein Renal Division in 1993 and chief of the Unified Renal Division (Einstein + Montefiore hospital) in 1998. He was vice-chairman for research in the Department of Medicine from 2000-2002. From 2002-2014, he was Baumritter Professor and University Chairman of the Department of Medicine at Albert Einstein College of Medicine and Montefiore Medical Center. Since 2014 he has been Senior Vice-Dean at Einstein.
Scientifically, Dr. Schuster has focused for more than 35 years on the interactions between vasoactive hormones and epithelial transport. His laboratory was the first to show that angiotensin II directly modulates fluid reabsorption by the proximal tubule. For a decade, he worked in acid-base physiology, characterizing the respective transporters of renal collecting duct a and b intercalated cells.
In 1995, his laboratory discovered the prostaglandin (PG) transporter "PGT", a finding he has extended to human and mouse genetics, zebrafish, and drug discovery. His laboratory has advanced the hypothesis that PG signaling is akin to neuronal signaling, i.e. the signaling molecule is released and then taken up again by the same cell. Because PGT regulates the expression of, and signaling via, PG receptors, it comprises a new therapeutic target for modulating prostanoid signaling. Indeed, a major focus of the lab has been to identify and create small-molecule PGT inhibitors as medicinal approaches to therapeutically raising the levels of endogenous prostaglandins. He was elected to the American Society for Clinical Investigation (1992) and the Association of American Physicians (1998).
Dr. Schuster is active in clinical medicine and teaching. He serves as the attending physician both on the Renal Consult Service and the inpatient Internal Medicine service; is a frequent discussant of clinical cases with the house staff ("chief of service rounds"); and regularly lectures on renal physiology, pathophysiology, disease, and translational research careers to the Einstein medical students, MD-PhD students, renal fellows, and CRTP students.
Kanai,N Lu,R Satriano,J Bao,Y Wolkoff,AW Schuster,VL. Identification and characterization of a prostaglandin transporter. Science 268: 866-869, 1995.
Itoh,S Lu,R Bao,Y Morrow,JD Roberts,LJ Schuster,VL. Structural determinants of substrates for the prostaglandin transporter "PGT". Mol Pharm 50: 736-742, 1996.
Lu,R Kanai,N Bao,Y Schuster,VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA "hPGT". J Clin Invest 98: 1142-1149, 1996.
Schuster,VL Lu,R Coca-Prados,M. Identification and characterization of a prostaglandin transporter widely-expressed in ocular and other secretory epithelia. Survey Ophthalmol 41: S41-S45, 1997.
Schuster,VL. Molecular mechanisms of prostaglandin transport. Ann Rev Physiol 60: 221-242, 1998.
Chan,B Satriano,JA Pucci,M Schuster,VL. Mechanism of PGE2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT". J Biol Chem 273: 6689-6697, 1998.
Lu,R Schuster,VL. Molecular cloning of the gene for the human prostaglandin transporter hPGT: Gene organization, promoter activity, and chromosomal localization. Biochem Biophys Res Comm 246: 805-812, 1998.
Pucci,M Bao,Y Chan,B Itoh,S Lu,R Copeland,NG Gilbert,DA Jenkins,NA Schuster,VL. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol (Regulatory) 277: R734-R741, 1999.
Chan,BS Satriano,JA Schuster,VL. Mapping the substrate binding site of the prostaglandin transporter PGT by cysteine scanning mutagenesis. J Biol Chem 274: 25564-25570, 1999.
Schuster,VL Itoh,S Andrews,SW Chen,J Kedzie,KM Krauss,HA Woodward,DF. Structural requirements for binding of prostaglandins to the prostaglandin FP receptor versus the prostaglandin transporter PGT. Mol Pharmacol 58: 1511-1516, 2000.
Endo,S Nomura,T Chan,BS Lu,R Pucci,ML Bao,Y Schuster,VL. Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport. Am J Physiol 282: F618-F622, 2002
Bao,Y Pucci,ML Chan,BS Lu,R Itoh,S Schuster,VL. Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids. Am J Physiol (Renal) 282: F1103-1110, 2002.
Chan, BS Endo,S Kanai,N Schuster,VL. Identification of lactate as a substrate and a driving force for prostanoid transport by the prostaglandin transporter PGT. Am J Physiol (Renal) 282: F1097-1102, 2002.
van der Zwaag,B Verzijl,HTFM Beltran-Valero de Bernabe,D Schuster,VL van Bokhoven,H Kremer,H van Reen,M Wichers, GH Brunner,HG Padberg,GW. Mutation analysis in the candidate Mbius syndrome genes PGT and GATA2 on chromosome 3, and EGR2 on chromosome 10. J Med Genetics 39: e30, 2002
Chan,BS Bao,Y Schuster,VL. The role of conserved transmembrane cationic amino acids in the prostaglandin transporter PGT. Biochemistry 41: 9215-9221, 2002.
Schuster,VL. Prostaglandin transport. Prostaglandins and Other Lipid Mediators: 68-69: 633-647, 2002.
Nomura, T Lu,R Pucci,ML Schuster,VL. The two-step model of prostaglandin signal termination: in vitro reconstitution with the transporter PGT and prostaglandin 15 dehydrogenase. Molecular Pharmacology 65: 973-978, 2004.
Pucci,ML Chakkalakkal,B Liclican,EL Leedom,A Schuster,VL Abraham,NG. Augmented Heme Oxygenase-1 Induces Prostaglandin Uptake via the Prostaglandin Transporter in Micro-vascular Endothelial Cells. Biochem Biophys Res Commun. 323:1299-1305, 2004.
Nomura,T Chang,H-Y Lu,R Hankin,J Murphy,Rc Schuster,VL. Prostaglandin signaling in the renal collecting duct: release, reuptake, and oxidation in the same cell. J Biol Chem 280: 28424-28429, 2005.
Pucci,ML Endo,S Nomura,T Lu,R Khine,C Chan,B Bao,Y Schuster,VL. Coordinate control of prostaglandin E2 synthesis and reuptake by hyperosmolarity in renal medullary interstitial cells. Am J Physiology (Renal) 290: F641-F649, 2006
Chi,Y Khersonsky,SM Chang-Y-T Schuster,VL. Identification of a new class of PGT inhibitors and their biological effects on PGE2 transport. J Pharmacol Exp Therapeutics 316: 1346-1350, 2006
Chi, Y Pucci,ML Schuster,VL. Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts. Am J Physiol (Renal) 295: F765-F771, 2008
Chang, HY Locker, J Lu,R. Schuster,VL. Failure of Postnatal Ductus Arteriosus Closure in Prostaglandin Transporter–Deficient Mice. Circulation. 121:529-536, 2010.
Chi,Y Schuster,VL. The prostaglandin transporter PGT transports PGH2. Biochem Biophys Res Commun 395: 168-172, 2010
Chi,Y Min,J Jasmin,J-F Lisanti,MP Chang,Y-T Schuster,VL. Development of a high affinity inhibitor of the prostaglandin transporter PGT. J Pharmacol & Exp Therapeut 339: 1-9, 2011
Chi, Y Suadicani,SO Schuster,VL. Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharmacology Research & Perspectives 2: e00051, 2014
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