SELECTED PUBLICATIONS

Erlichman, J., Litvin, Y., and Fleischer, N.:Immunological and Molecular Characterization of cAMP‑dependent Protein Kinases in AtT‑20 cells. J. Biol. Chem. 259: 10289‑10295, 1984.

Leiser, M., Fleischer, N. and Erlichman, J.: Enhanced Activation of cAMP-dependent Protein Kinase by Rapid Synthesis and Degradation of cAMP. J. Biol. Chem. 261: 15486-15490, 1986.

Leiser, M., Fleischer, N. and Erlichman, J.: Enhanced Activation of cAMP-dependent Protein Kinase by Rapid Synthesis and Degradation of cAMP. J. Biol. Chem. 261: 15486-15490, 1986.

Bilezikjian, L.M., Erlichman, J., Fleischer, N. and Vale, W.W.: Differential activation of type I and type II cAMP-dependent protein kinases by growth hormone releasing factor. Molecular Endocrinology 1: 137-146,1987.

Fleischer, N., Liker, H., Stoller, T., and Shields, D.: Retrovirus-Mediated Expression of Preprosomatostatin in Rat Pituitary GH3 Cells: Targeting of somatostatin to the regulated secretory pathway. Molecular Endocrinology. 3:1652-1658, 1989.

Lomasky, S.J., D'Eramo, G., Shamoon, H. and Fleischer, N.: Relation of Insulin Secretion and Glycemic Recovery to Dietary Intervention in Non-Insulin-Dependent Diabetes. Arch. Intern. Med. 150:169-172, 1990.

Efrat, S., Fleischer, N., and Hanahan, D.: Diabetes Induced in Male Transgenic Mice by Expression of Human H-ras Oncoprotein in Pancreatic ©¬ Cells. Mol. Cell. Biol. 10: 1779-1783, 1990.

D'Ambra, R.D., Surana, M., Efrat, S., Starr, R.G., and Fleischer, N.: Regulation of Insulin Secretion from Beta Cell Lines Derived from Transgenic Mice Insulinomas Resembles That of Normal Beta Cells. Endocrinology 126: 2815-2822, 1990.

Efrat, S., Surana, M., and Fleischer, N.: Glucose induces insulin gene transcription in a murine ©¬-cell line. J. Biol. Chem., 266:11141-11143, 1991.

Tal, M., Thorens, B., Surana, M., Fleischer, N., Lodish, H. F., Hanahan, D., Efrat, S.: Glucose transporter isotypes switch in transformed pancreatic ©¬ cells. Mol. and Cell. Biol. 12:422-432, 1992.

Tal, M., Wu, Y-J, Leiser, M., Surana, S., Lodish, H., Fleischer, N., Weir, G., and Efrat, S.: [Val¹²]HRAS downregulates GLUT2 in ©¬ cells of transgenic mice without affecting glucose homeostasis. Proc. Natl. Acad. Sci. USA, 89:5744-5748, 1992.

Efrat, S., Leiser, M., Surana, M., Tal, M., Fusco-DeMane, D., and Fleischer, N.: A murine insulinoma cell line with normal glucose-regulated insulin secretion. Diabetes 42:901-907, 1993

Efrat, S., Leiser, M., Wu, Y-J., Fusco-DeMane, D., Emran, O., Surana. M., Weir, G., Jetton, T., Magnuson, M.A., and Fleischer, N.: Ribozyme-mediated attenuation of pancreatic ©¬-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci (USA), 91:2051-2055, 1994.

Knaack, D., Fiore, D.M., Surana, M., Leiser, M., Laurance, M., Fusco-DeMane, D., Fleischer, N., and Efrat, S.: Clonal insulinoma cell line which maintains correct glucose responsiveness. Diabetes 43:1413-1417, 1994

Leiser, M., Efrat, S., and Fleischer, N.: Evidence that RAP1 carboxylmethylation is involved in regulated insulin secretion. Endocrinology 136: 2521-2530, 1995.

Bali, D., Svetlanov, A., Lee, H., Fusco-DeMane, D., Leiser, M., Li, B., Barzilai, N., Surana, M., Hou, H., Fleischer, N., DePinho, R., Rossetti, L., and Efrat, S.: Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270:21464-21467, 1995.

Leiser, M., and Fleischer, N., cAMP-Dependent Phosphorylation of the Cardiac-type a1 Subunit of the Voltage-dependent Ca⁺⁺ Channel in a Murine Pancreatic ©¬-Cell Line. Diabetes 45:1412-1418, 1996.

Fleischer, N., Chen, C., Surana, M., Leiser, M., Rossetti, L., Pralong, W., and Efrat, S., Functional Analysis of a Conditionally-Transformed Pancreatic ©¬-Cell Line. Diabetes 47:1419-1425, 1998.

Han P, Werber J, Surana M, Fleischer N and Michaeli T:The calcium calmodulin dependent phosphodiesterase PDE1C down‑regulates glucose induced insulin secretion. J. Biol. Chem. 274:22337‑44, 1999.

Sooy K, Schermerhorn T, Noda M, Rhoten WB, Meyer M, Fleischer N, Sharp GWG, Christakos S: Calbindin-D_28k controls [Ca²⁺]_i and insulin release: evidence obtained from calbindin-D_28k knockout mice and cell lines. J.Biol. Chem., 274:34343-49, 1999.

Efrat S, and Fleischer N: Engineering the pancreatic ¥â-cell. In Diabetes Mellitus (D. LeRoith, S. Taylor, J. Olefsky, eds.) Lippincott-Raven, Philadelphia, p535-541, 2000

Cases, JA, Gabriely I, Xiao HM, Xiao MY, Michaeli T, Fleischer N, Rossetti L, Barzilai N: Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 50:348-352, 2001.

Milo-Landesman D, Surana M, Berkovich I, Compagni A, Christofori G, Fleischer N and Efrat S: Correction of hyperglycemia in diabetic mice transplanted with reversibly-immortalized pancreatic b cells controlled by the tet-on regulatory system. Cell Transplantation 10:645-659 (2001).

Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BJ, Karnieli O, Zern MA, Fleischer N, and Efrat S. Reversal of hyperglycemia in mice using human expandable insulin-producing cells differentiated from fetal liver progenitor cells; Proc. Natl. Acad. Sci.(USA), 100:7253-7258, 2003

Howard A, Floris-Moore M, Arnsten J, Santoro N, Fleischer N, Lo Yungtai, Schoenbaum E, Disorders of Glucose Metabolism among HIV-Infected Women Clinical Infectious Diseases 2005; 40:1491-9

Howard A, Floris-Moore M. Lo Y, Arnsten JH, Fleischer N, Klein RS, Abnormal glucose metabolism among older men with or at risk of HIV infection; 2006 British HIV Association; HIV Medicine (2006), 7, 389-396

Howard A, Lo Y, Floris-Moore M., Schoenbaum E, Fleischer N, Klein RS, Hepatitis C Virus Infection is Associated with Insulin Resistance among Older Adults with or At-Risk for HIV Infection. AIDS 2006 (in press).