Einstein/Montefiore Department of Medicine

Department Faculty

Luis R. Martinez, Ph.D.

Dr. Luis R. Martinez

Adjunct Clinical Assistant Professor, Department of Medicine (Infectious Diseases)

 

Professional Interests

We are interested in understanding two basic questions:

  1. Which mechanisms are used by microbes to invade, survive, and cause disease to the host?
  2. How does the host defend itself against microbial assault?    

We approach our research in an interdisciplinary manner, undergraduate and graduate students that join the lab will be trained on basic microbiology, microscopy, immunological and tissue culture techniques, molecular biology, antimicrobial research, and animal models of infection.

Current projects include:

  1. Impact of methamphetamine on infection and immunity.
  2. Pathogenesis of multi-drug resistant and causative agent of hospital-related infections, Acinetobacter baumannii
  3. Development of strategies for treatment of microbial biofilms.
  4. Application of nitric oxide-releasing nanotechnology for treatment of cutaneous infections.

In addition to our ongoing research projects, we also prioritize our involvement in citizen science. In collaboration with the School of Liberal Arts and Sciences at C.W. Post, we are part of a summer workshop that provides teachers from Long Island high schools with a practical understanding of the framework for initiating and mentoring students in research projects.

We are part of the Department of Biomedical Sciences in the School of Health Professions and Nursing at C.W. Post, and are also affiliated with the Departments of Medicine (Infectious Diseases) and Microbiology and Immunology at Albert Einstein College of Medicine, Bronx, NY.

 

Selected Publications

  1. Han, G., L. N. Nguyen, C. Macherla, J. M. Friedman, J. D. Nosanchuk, and L. R. Martinez. 2012. Nitric oxide releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am J Pathol. In Press.
  2. Schairer, D., L. R. Martinez, K. Blecher, J. Chouake, P. Nacharaju, P. Gialanella, J. M. Friedman, J.D. Nosanchuk, and A. J.  Friedman. 2012. Nitric oxide nanoparticles: Pre-clinical utility as a therapeutic for intramuscular abscesses. Virulence. In Press.
  3. Silva, F., D. Rossi, L. R. Martinez, S. Frases, F. Fonseca, C. Campos, M. Rodrigues, J. D. Nosanchuk, and S. Daffre. 2011. Effects of microplusin, a copper-chelating antimicrobial peptide, against Cryptococcus neoformans. FEMS Microbiol Lett. 324:64-72.
  4. Cordero, R. J., B. Pontes, A. J. Guimaräes, L. R. Martinez, J. Rivera, B. C. Fries, L. Nimrichter, M. L. Rodrigues, N. B. Viana, and A. Casadevall. 2011. Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans. Infect Immun. 79:4990-5000.
  5. Friedman, A. J., K. Blecher, D. Schairer, C. Tuckman-Vernon, P. Nacharaju, D. Sanchez, P. Gialanella, L. R. Martinez, J. M. Friedman, and J. D. Nosanchuk. 2011. Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. Nitric Oxide. 25:381-386
  6. Friedman, A. J., K. Blecher, D. Sanchez, C. Tuckman-Vernon, P. Gialanella, J. M. Friedman, L. R. Martinez, and J. D. Nosanchuk. 2011. Susceptibility of Gram Positive and Negative Bacteria to Novel Nitric Oxide-Releasing Nanoparticle Technology. Virulence. 2:217-221.
  7. Nguyen, L. N., D. Trofa, B. Kadereit, Z. Hamari, M. Agovino, L. R. Martinez, A. Gacser, D. L. Silver, and J. D. Nosanchuk. 2011. Candida parapsilosis Fat storage-Inducing Transmembrane (FIT) protein 2 Regulates Lipid Droplet Formation and Impacts Virulence. Microbes Infect. 13: 663-672.
  8. Prados-Rosales, R., A. Baena, L. R.  Martinez, J. Luque-Garcia, R. Kalscheuer, U. Veeraraghavan, C. Camara, J. D. Nosanchuk, G. S. Besra, B. Chen, J. Jimenez, A. Glatman-Freedman, W. R. Jacobs Jr, S. A. Porcelli, and A. Casadevall. 2011. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2 dependent-manner in mice. J Clin Invest.  121:1471-83.
  9. Mihu, M. R. and L. R. Martinez. 2011. Novel therapies for treatment of multi-drug resistant Acinetobacter baumannii skin infections.  Virulence. 2:97-102 {Invited review}.
  10. Guimarães, A. J., L. R. Martinez, and J. D. Nosanchuk. 2011.  Passive administration of monoclonal antibodies against fungal pathogens. J Vis Exp. 48:2532.
 

More Information About Dr. Luis Martinez

Martinez Lab website

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Long Island University
720 Northern Boulevard
Building LS350
Brookville, NY 11548

Tel: 516.299.3047
Fax: 516.299.3998
lmartine@einstein.yu.edu

 
Pubmed Search

Media Coverage

Methamphetamine users are more vulnerable to fungal lung infections according to new research by Dr. Luis Martinez featured in The Los Angeles Times.

More media coverage