Einstein/Montefiore Department of Medicine

Department Faculty

Streamson C. Chua, Jr., M.D., Ph.D.

Dr. Streamson C. Chua, Jr.
 

Professional Interests

Dr. Streamson Chua's group is interested in genetic contribution to the chronic disease of obesity, diabetes, and diabetes complications. One interest is in developing an understanding of the various functions of leptin responsive neurons as they relate to ingestion, control of body composition, metabolism, and reproduction. A second interest is to dissect the genetic contribution to the susceptibility/resistance to complications of long term hyperglycemia, particularly effects on the endocrine pancreas and the kidney.

Background

Before coming to Einstein in 2005, Dr. Streamson Chua was a member of the group of Dr. Jules Hirsch and Dr. Rudolph Leibel at the Rockefeller University, where he participated in efforts to understand the genetics of obesity. He then joined the faculty of Columbia-Presbyterian Medical School as an associate professor, continuing his work on the function of the hormone leptin that influences obesity and diabetes. Currently, he is pursuing research on genes that are linked to increased susceptibility to obesity and diabetic complications, particularly beta cell loss and nephropathy. Dr. Chua received his bachelor’s degree from Johns Hopkins University, and then earned a combined M.D.-Ph.D. at Columbia University. He completed a one-year internship at New York Hospital and then undertook a post-doctoral fellowship in pediatric endocrinology to clone the gene for the steroid-producing enzyme, 11 beta hydroxylase.

 

Selected Publications

Reviews, Chapters, and Editorials 

  1. Chua, S.C. and M.F. Maylie-Pfenninger. A cell surface 105 kD antigen, present on multipotential teratocarcinoma lines but not on Nulli, involved in mouse preimplantation development. In: Teratocarcinoma Stem Cells, eds. G.R. Martin, L. Silver and S. Strickland. 1983. 
  2. Hirsch, J., R.L. Leibel and S.C. Chua. A Clinical Perspective on Peptides and Food Intake: Pharmacological Treatment of Obesity, Satellite Symposium to the 6th International Congress on Obesity, Japan, October 21-26, 1990. American Journal of Clinical Nutrition 55(Supplement):296S-298S, 1992. 
  3. Chua, S.C., J.L. LaChaussee. Letters: Molecular pathogenesis of obesity in the fatty rat. Appetite. 21:303, 1993. 
  4. Chua, S.C. and R.L. Leibel. Molecular genetic approaches to obesity. In C. Bouchard ed.. Genetics of Obesity. CRC Press. Boca Raton. pp. 213-222, 1994. 
  5. Leibel, R.L., S.C. Chua, and W.K. Chung. Animal models of genetic obesity. In A. Angel, H. Anderson, C. Bourchard, D. Lau, L. Leiter and R. Mendelson eds. Progress in Obesity Research: 
  6. John Libbey & Company, Ltd. London/7th International Congress on Obesity. pp. 263-217, 1995. 
  7. Chua, S.C. and R. L. Leibel. An Ounce of Prevention. (Editorial). Journal of Pediatrics. 128:591-593, 1996. 
  8. Chua, S.C. and R.L. Leibel. Obesity genes: Molecular and metabolic mechanisms. Diabetes Reviews, 5:2-7, 1996. 
  9. Chua, S.C., Models of Monogenic Obesity, Behavioral Genetics. 27:277-284, 1997. 
  10. Leibel, R.L., W.K. Chung, and S.C. Chua. The molecular genetics of rodent single gene obesities. Journal of Biological Chemistry 272:31937-31940, 1997. 
  11. Leibel, R.L. S.C. Chua and M. Rosenbaum, Obesity: The Molecular Physiology of Weight Regulation, in The Metabolic and Molecular Bases of Inherited Disease, VIII Edit., C.R. Scriver, A.L. Beaudel, W.S.Slu and D. Valle, edit. 2001. 
  12. Chua, S.C., and R.L. Leibel, Body Weight Regulation: Neural, Endocrrine, and Autocrine Mechanisms, in Obesity: Theory and Therapy, ed. Albert J. J. Stunkard and Thomas A. Wadden, Lippincott-Raven, 2001. 
  13. Chua, S.C., K. Graham and R.L. Leibel, Molecular Genetics of Rodent and Human Single Gene Mutations Affecting Body Composition, in Handbook of Obesity, Etiology and Pathophysiology (second edition), ed. G.A. Bray and C. Bouchard, Marcel Dekker, 2003. 
  14. Chua, SC Jr., L Herberg, and EH Leiter, Obesity/diabetes in mice with mutations in the leptin or leptin receptor genes: an update, in Frontiers in animal models of diabetes research (second edition). ed. E. Shafrir, CRC Press, 2006 (in press). 

Original Articles [1-59] 

  1. Chua, S.C., et al., Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11). Proceedings of the National Academy of Sciences U S A, 1987. 84(20): p. 7193-7. 
  2. Mouw, A.R., et al., Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase. Journal of Biological Chemistry, 1989. 264(2): p. 1305-9. 
  3. Chua, S.C., Jr., et al., Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Brain Research Molecular Brain Research, 1991. 11(3-4): p. 291-9. 
  4. Chua, S.C., Jr., R.L. Leibel, and J. Hirsch, Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Brain Research Molecular Brain Research, 1991. 9(1-2): p. 95-101. 
  5. Galbraith, R.A., S.C. Chua, Jr., and A. Kappas, Hypothalamic mechanism for cobalt protoporphyrin-induced hypophagia and weight loss: inhibition of the feeding response to NPY. Brain Research Molecular Brain Research, 1992. 15(3-4): p. 298-302. 6.
  6. Chua, S.C., et al., The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome Mammalian Genome, 1993. 4(10): p. 555-9. 
  7. Chua, S.C., et al., Utility of a c-Jun microsatellite in determining gene dosage for fatty (fa). Obesity Research, 1993. 1: p. 475-480. 
  8. Jhanwar-Uniyal, M. and S.C. Chua, Jr., Critical effects of aging and nutritional state on hypothalamic neuropeptide Y and galanin gene expression in lean and genetically obese Zucker rats. Brain Research Molecular Brain Research, 1993. 19(3): p. 195-202. 
  9. Power, L.M., S.C. Chua, Jr., and R.L. Leibel, Locus D1S21 contains exonic sequence from the C8 beta component of complement. Mammalian Genome, 1994. 5(2): p. 125-6. 
  10. Wajnrajch, M.P., et al., Human growth hormone-releasing hormone receptor (GHRHR) maps to a YAC at chromosome 7p15. Mammalian Genome, 1994. 5(9): p. 595. 
  11. Green, E.D., et al., The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Research, 1995. 5(1): p. 5-12. 
  12. Kershaw, E.E., et al., Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus. Genomics, 1995. 27(1): p. 149-54. 
  13. Kershaw, E.E., S.C. Chua, Jr., and R.L. Leibel, Localization of a (CA)n repeat in glucagon-like peptide-1 receptor gene (Glp1r) to proximal mouse chromosome 17 and its linkage to other markers. Mammalian Genome, 1995. 6(4): p. 301-3. 
  14. Chua, S.C., Jr., et al., Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes, 1996. 45(8): p. 1141-3. 
  15. Chua, S.C., Jr., et al., Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 1996. 271(5251): p. 994-6. 
  16. Meierfrankenfeld, B., et al., Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. American Journal of Physiology, 1996. 270(4 Pt 1): p. E700-8. 
  17. Norman, R.A., et al., Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes, 1996. 45(9): p. 1229-32. 
  18. Wajnrajch, M.P., et al., Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nature Genetics, 1996. 12(1): p. 88-90. 
  19. Chagnon, Y.C., et al., Suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study. Obesity Research, 1997. 5(2): p. 115-21. 
  20. Chua, S.C., Jr., et al., Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics, 1997. 45(2): p. 264-70. 
  21. Chung, W.K., et al., Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Genomics, 1997. 41(3): p. 332-44. 
  22. Chung, W.K., et al., PCR-RFLP and SSCP assays for the mouse obese (Lep-ob) mutation. Obesity Research, 1997. 5: p. 183-185. 
  23. Kahle, E.B., et al., The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation. Obesity Research, 1997. 5(2): p. 142-5. 
  24. Ware, M.L., et al., Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron, 1997. 19(2): p. 239-49. 
  25. White, D.W., et al., Constitutive and impaired signaling of leptin receptors containing the Gln --> Pro extracellular domain fatty mutation. Proceeding of the National Academy of Sciences U S A, 1997. 94(20): p. 10657-62. 
  26. Wu-Peng, X.S., et al., Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes, 1997. 46(3): p. 513-8. 
  27. Kowalski, T.J., et al., Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups. American Journal of Physiology, 1998. 275(2 Pt 2): p. R466-70. 
  28. Liu, S.M., R.L. Leibel, and S.C. Chua, Jr., Partial duplication in the leprdb-Pas mutation is a result of unequal crossing over. Mammalian Genome, 1998. 9(9): p. 780-1. 
  29. Schreyer, S.A., S.C. Chua, Jr., and R.C. LeBoeuf, Obesity and diabetes in TNF-alpha receptor- deficient mice. Journal of Clinical Investigation, 1998. 102(2): p. 402-11. 
  30. Korner, J., et al., Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology, 1999. 70(6): p. 377-83. 
  31. Kowalski, T.J., et al., Neuropeptide Y overexpression in the preweanling Zucker (fa/fa) rat. Physiology and Behavior, 1999. 67(4): p. 521-5. 
  32. Wu-Peng, S., et al., Effects of exogenous gonadal steroids on leptin homeostasis in rats. Obesity Research, 1999. 7(6): p. 586-92. 
  33. Brown, J.A., et al., Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. American Journal of Physiology Regulatory and Integrated Comparative Physiology, 2000. 278(2): p. R320-30. 
  34. Korner, J., et al., Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Endocrinology, 2000. 141(7): p. 2465-71. 
  35. Wildman, H.F., et al., Effects of leptin and cholecystokinin in rats with a null mutation of the leptin receptor Lepr(fak). American Journal of Physiology Regulatory and Integrated Comparative Physiology, 2000. 278(6): p. R1518-23. 
  36. Hsing, A.W., et al., Prostate cancer risk and serum levels of insulin and leptin: a population-based study. Journal of the National Cancer Institute, 2001. 93(10): p. 783-9. 
  37. Ko, C., et al., Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. Journal of Lipid Research, 2001. 42(5): p. 844-55. 
  38. Korner, J., et al., Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. Journal of Neuroendocrinology, 2001. 13(11): p. 959-66. 
  39. Kowalski, T.J., et al., Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes, 2001. 50(2): p. 425-35. 
  40. Chua, S., Jr., et al., Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia, 2002. 45(7): p. 976-90. 
  41. Ho, G.Y., et al., Polymorphism of the insulin gene is associated with increased prostate cancer risk. British Journal of Cancer, 2003. 88(2): p. 263-9.
  42. Hsing, A.W., et al., Insulin resistance and prostate cancer risk. Journal of the National Cancer Institute, 2003. 95(1): p. 67-71. 
  43. Levin, B.E., et al., A new obesity-prone, glucose intolerant rat strain (F.DIO). American Journal of Physiology Regulatory and Integrated Comparative Physiology, 2003. 
  44. Balthasar, N., et al., Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron, 2004. 42(6): p. 983-91. 
  45. Chua, S.C., Jr., et al., Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Am J Physiol Endocrinol Metab, 2004. 286(3): p. E384-92
  46. Chua, S.C., Jr., Molecular and cellular correlates of the developmental acquisition of mechanisms modulating ingestive behavior. Physiol Behav, 2004. 82(1): p. 145-7. 
  47. Haluzik, M., et al., Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology, 2004. 
  48. McMinn, J.E., et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome, 2004. 15(9): p. 677-85. 
  49. Savontaus, E., et al., Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology, 2004. 145(8): p. 3881-91. 
  50. Tortoriello, D.V., J. McMinn, and S.C. Chua, Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology, 2004. 145(3): p. 1238-47. 
  51. de Luca, C., et al., Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest, 2005. 115(12): p. 3484-93. 
  52. Jo, Y.H., et al., Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron, 2005. 48(6): p. 1055-66. 
  53. Levin, B.E., et al., F-DIO obesity-prone rat is insulin resistant before obesity onset. Am J Physiol Regul Integr Comp Physiol, 2005. 289(3): p. R704-11. 
  54. McMinn, J.E., et al., Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. Am J Physiol Endocrinol Metab, 2005. 289(3): p. E403-11. 
  55. Wang, Z., et al., Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes, 2005. 54(8): p. 2328-35. 
  56. Zheng, Z., et al., A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc Natl Acad Sci U S A, 2005. 102(7): p. 2502-7. 
  57. Dhillon, H., et al., Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis. Neuron, 2006. 49(2): p. 191-203. 
  58. Kitamura, T., et al., Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med, 2006. 
  59. Luo, N., et al., Allelic Variation on Chromosome 5 Controls {beta}-Cell Mass Expansion during Hyperglycemia in Leptin Receptor-Deficient Diabetes Mice. Endocrinology, 2006. 147(5): p. 2287-95.
  60. 1.         Chua SC, Szabo P, Vitek A, Grzeschik KH, John M, White PC 1987 Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11). Proceedings of the National Academy of Sciences U S A 84:7193-7197

    2.         Mouw AR, Rice DA, Meade JC, Chua SC, White PC, Schimmer BP, Parker KL 1989 Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase. Journal of Biological Chemistry 264:1305-1309

    3.         Chua SC, Jr., Brown AW, Kim J, Hennessey KL, Leibel RL, Hirsch J 1991 Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Brain Research Molecular Brain Research 11:291-299

    4.         Chua SC, Jr., Leibel RL, Hirsch J 1991 Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Brain Research Molecular Brain Research 9:95-101

    5.         Galbraith RA, Chua SC, Jr., Kappas A 1992 Hypothalamic mechanism for cobalt protoporphyrin-induced hypophagia and weight loss: inhibition of the feeding response to NPY. Brain Research Molecular Brain Research 15:298-302

    6.         Chua SC, Hansen M, Truett G, Leibel RL 1993 Utility of a c-Jun microsatellite in determining gene dosage for fatty (fa). Obesity Research 1:475-480

    7.         Chua SC, Hennessey K, Zeitler P, Leibel RL 1993 The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6. Mammalian Genome 4:555-559

    8.         Jhanwar-Uniyal M, Chua SC, Jr. 1993 Critical effects of aging and nutritional state on hypothalamic neuropeptide Y and galanin gene expression in lean and genetically obese Zucker rats. Brain Research Molecular Brain Research 19:195-202

    9.         Power LM, Chua SC, Jr., Leibel RL 1994 Locus D1S21 contains exonic sequence from the C8 beta component of complement. Mammalian Genome 5:125-126

    10.       Wajnrajch MP, Chua SC, Green ED, Leibel RL 1994 Human growth hormone-releasing hormone receptor (GHRHR) maps to a YAC at chromosome 7p15. Mammalian Genome 5:595

    11.       Green ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC, Jr., Leibel RL, Weissenbach J, Friedman JM 1995 The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Research 5:5-12

    12.       Kershaw EE, Chua SC, Jr., Leibel RL 1995 Localization of a (CA)n repeat in glucagon-like peptide-1 receptor gene (Glp1r) to proximal mouse chromosome 17 and its linkage to other markers. Mammalian Genome 6:301-303

    13.       Kershaw EE, Chua SC, Williams JA, Murphy EM, Leibel RL 1995 Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus. Genomics 27:149-154

    14.       Chua SC, Jr., Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996

    15.       Chua SC, Jr., White DW, Wu-Peng XS, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, Leibel RL 1996 Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45:1141-1143

    16.       Meierfrankenfeld B, Abelenda M, Jauker H, Klingenspor M, Kershaw EE, Chua SC, Jr., Leibel RL, Schmidt I 1996 Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. American Journal of Physiology 270:E700-708

    17.       Norman RA, Leibel RL, Chung WK, Power-Kehoe L, Chua SC, Jr., Knowler WC, Thompson DB, Bogardus C, Ravussin E 1996 Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes 45:1229-1232

    18.       Wajnrajch MP, Gertner JM, Harbison MD, Chua SC, Jr., Leibel RL 1996 Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nature Genetics 12:88-90

    19.       Chua SC, Jr., Koutras IK, Han L, Liu SM, Kay J, Young SJ, Chung WK, Leibel RL 1997 Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45:264-270

    20.       Chung WK, Chua SC, Lee G-H, Leibel RL 1997 PCR-RFLP and SSCP assays for the mouse obese (Lep-ob) mutation. Obesity Research 5:183-185

    21.       Chung WK, Zheng M, Chua M, Kershaw E, Power-Kehoe L, Tsuji M, Wu-Peng XS, Williams J, Chua SC, Jr., Leibel RL 1997 Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41:332-344

    22.       Kahle EB, Butz KG, Chua SC, Kershaw EE, Leibel RL, Fenger TW, Hansen CT, Michaelis OE 1997 The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation. Obesity Research 5:142-145

    23.       Ware ML, Fox JW, Gonzalez JL, Davis NM, Lambert de Rouvroit C, Russo CJ, Chua SC, Jr., Goffinet AM, Walsh CA 1997 Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron 19:239-249

    24.       White DW, Wang DW, Chua SC, Jr., Morgenstern JP, Leibel RL, Baumann H, Tartaglia LA 1997 Constitutive and impaired signaling of leptin receptors containing the Gln --> Pro extracellular domain fatty mutation. Proceeding of the National Academy of Sciences U S A 94:10657-10662

    25.       Wu-Peng XS, Chua SC, Jr., Okada N, Liu SM, Nicolson M, Leibel RL 1997 Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 46:513-518

    26.       Kowalski TJ, Houpt TA, Jahng J, Okada N, Chua SC, Jr., Smith GP 1998 Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups. American Journal of Physiology 275:R466-470

    27.       Liu SM, Leibel RL, Chua SC, Jr. 1998 Partial duplication in the leprdb-Pas mutation is a result of unequal crossing over. Mammalian Genome 9:780-781

    28.       Schreyer SA, Chua SC, Jr., LeBoeuf RC 1998 Obesity and diabetes in TNF-alpha receptor- deficient mice. Journal of Clinical Investigation 102:402-411

    29.       Korner J, Chua SC, Jr., Williams JA, Leibel RL, Wardlaw SL 1999 Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 70:377-383

    30.       Kowalski TJ, Houpt TA, Jahng J, Okada N, Liu SM, Chua SC, Jr., Smith GP 1999 Neuropeptide Y overexpression in the preweanling Zucker (fa/fa) rat. Physiology and Behavior 67:521-525

    31.       Wu-Peng S, Rosenbaum M, Nicolson M, Chua SC, Leibel RL 1999 Effects of exogenous gonadal steroids on leptin homeostasis in rats. Obesity Research 7:586-592

    32.       Brown JA, Chua SC, Jr., Liu SM, Andrews MT, Vandenbergh JG 2000 Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. American Journal of Physiology Regulatory and Integrated Comparative Physiology 278:R320-330

    33.       Korner J, Wardlaw SL, Liu SM, Conwell IM, Leibel RL, Chua SC, Jr. 2000 Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Endocrinology 141:2465-2471

    34.       Wildman HF, Chua S, Jr., Leibel RL, Smith GP 2000 Effects of leptin and cholecystokinin in rats with a null mutation of the leptin receptor Lepr(fak). American Journal of Physiology Regulatory and Integrated Comparative Physiology 278:R1518-1523

    35.       Hsing AW, Chua S, Jr., Gao YT, Gentzschein E, Chang L, Deng J, Stanczyk FZ 2001 Prostate cancer risk and serum levels of insulin and leptin: a population-based study. Journal of the National Cancer Institute 93:783-789

    36.       Ko C, Lee TL, Lau PW, Li J, Davis BT, Voyiaziakis E, Allison DB, Chua SC, Jr., Huang LS 2001 Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. Journal of Lipid Research 42:844-855

    37.       Korner J, Savontaus E, Chua SC, Jr., Leibel RL, Wardlaw SL 2001 Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. Journal of Neuroendocrinology 13:959-966

    38.       Kowalski TJ, Liu SM, Leibel RL, Chua SC, Jr. 2001 Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 50:425-435

    39.       Chua S, Jr., Liu SM, Li Q, Yang L, Thassanapaff VT, Fisher P 2002 Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia 45:976-990

    40.       Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R, Chua SC, Jr. 2003 Polymorphism of the insulin gene is associated with increased prostate cancer risk. British Journal of Cancer 88:263-269

    41.       Hsing AW, Gao YT, Chua S, Jr., Deng J, Stanczyk FZ 2003 Insulin resistance and prostate cancer risk. Journal of the National Cancer Institute 95:67-71

    42.       Levin BE, Dunn-Meynell AA, McMinn JE, Alperovich M, Cunningham-Bussel A, Chua Jr SC 2003 A new obesity-prone, glucose intolerant rat strain (F.DIO). American Journal of Physiology Regulatory and Integrated Comparative Physiology 285:R1184-1191

    43.       Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Jr., Elmquist JK, Lowell BB 2004 Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42:983-991

    44.       Chua SC, Jr. 2004 Molecular and cellular correlates of the developmental acquisition of mechanisms modulating ingestive behavior. Physiol Behav 82:145-147

    45.       Chua SC, Jr., Liu SM, Li Q, Sun A, DeNino WF, Heymsfield SB, Guo XE 2004 Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Am J Physiol Endocrinol Metab 286:E384-392

    46.       Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML 2004 Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145:3258-3264

    47.       McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC, Jr. 2004 An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome 15:677-685

    48.       Savontaus E, Breen TL, Kim A, Yang LM, Chua SC, Jr., Wardlaw SL 2004 Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145:3881-3891

    49.       Tortoriello DV, McMinn J, Chua SC 2004 Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology 145:1238-1247

    50.       de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC, Jr. 2005 Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115:3484-3493

    51.       Jo YH, Chen YJ, Chua SC, Jr., Talmage DA, Role LW 2005 Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 48:1055-1066

    52.       Levin BE, Magnan C, Migrenne S, Chua SC, Jr., Dunn-Meynell AA 2005 F-DIO obesity-prone rat is insulin resistant before obesity onset. Am J Physiol Regul Integr Comp Physiol 289:R704-711

    53.       McMinn JE, Liu SM, Liu H, Dragatsis I, Dietrich P, Ludwig T, Boozer CN, Chua SC, Jr. 2005 Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. Am J Physiol Endocrinol Metab 289:E403-411

    54.       Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M 2005 Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 54:2328-2335

    55.       Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D'Agati VD, Gharavi AG 2005 A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc Natl Acad Sci U S A 102:2502-2507

    56.       Collins SJ, Alexander SL, Lopez-Guisa JM, Cai X, Maruvada R, Chua SC, Zhang G, Okamura DM, Matsuo S, Eddy AA 2006 Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. Nephron Exp Nephrol 104:e23-34

    57.       Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ 2006 The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4:291-302

    58.       Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Jr., Elmquist JK, Lowell BB 2006 Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis. Neuron 49:191-203

    59.       Kitamura T, Feng Y, Kitamura YI, Chua SC, Jr., Xu AW, Barsh GS, Rossetti L, Accili D 2006 Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med 12:534-540

    60.       Luo N, Liu SM, Liu H, Li Q, Xu Q, Sun X, Davis B, Li J, Chua S, Jr. 2006 Allelic Variation on Chromosome 5 Controls {beta}-Cell Mass Expansion during Hyperglycemia in Leptin Receptor-Deficient Diabetes Mice. Endocrinology 147:2287-2295

    61.       Zheng Z, Pavlidis P, Chua S, D'Agati VD, Gharavi AG 2006 An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse. J Am Soc Nephrol 17:1796-1800

    62.       Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S, Jr., Zhang Y 2007 Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology 148:3987-3997

    63.       Hsing AW, Sakoda LC, Chua S, Jr. 2007 Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr 86:s843-857

    64.       Lee M, Kim A, Chua SC, Jr., Obici S, Wardlaw SL 2007 Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293:E121-131

    65.       Tortoriello DV, McMinn JE, Chua SC 2007 Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL/6J mice. Int J Obes (Lond) 31:395-402

    66.       Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Jr., Chua SC, Jr., Kim JK, Kaestner KH, Karsenty G 2008 The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183:1235-1242

    67.       Kim KW, Jo YH, Zhao L, Stallings NR, Chua SC, Jr., Parker KL 2008 Steroidogenic Factor 1 Regulates Expression of the Cannabinoid Receptor 1 in the Ventromedial Hypothalamic Nucleus. Mol Endocrinol 22:1950-1961

    68.       Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC, Jr., Huang LS 2008 Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 283:13087-13099

    69.       van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, Mackenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Jr., Schwartz GJ, Chua SC, Jr. 2008 Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149:1773-1785

    70.       Jo YH, Su Y, Gutierrez-Juarez R, Chua S, Jr. 2009 Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol 101:2305-2316

    71.       Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE 2009 Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29:1575-1591

    72.       Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S, Jr., Diano S, Horvath TL, Seeley RJ, Becker JB, Munzberg H, Myers MG, Jr. 2009 Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 10:89-98

    73.       Stratigopoulos G, Leduc CA, Matsuoka N, Gutman R, Rausch R, Robertson SA, Myers MG, Jr., Chung WK, Chua SC, Jr., Leibel RL 2009 Functional Consequences of the Human Leptin Receptor (LEPR) Q223R Transversion. Obesity (Silver Spring) 17:126-135

    74.       Chua S, Jr., Li Y, Liu SM, Liu R, Chan KT, Martino J, Zheng Z, Susztak K, D'Agati VD, Gharavi AG 2010 A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8. Kidney Int 78:453-462

    75.       Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Bruning JC, Elmquist JK 2010 Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab 11:286-297

    76.       Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD, Kieffer TJ 2010 Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes 59:3032-3040

    77.       Iqbal J, Li X, Chang BH, Chan L, Schwartz GJ, Chua SC, Jr., Hussain MM 2010 An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption. J Lipid Res 51:1929-1942

    78.       Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa WMD, Oki M, Chua S, Jr., Itoh H, Noda T, Kasuga M, Nakae J 2010 PDK1/ FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab 298:E787-798

    79.       Nagajyothi F, Zhao D, Machado FS, Weiss LM, Schwartz GJ, Desruisseaux MS, Zhao Y, Factor SM, Huang H, Albanese C, Teixeira MM, Scherer PE, Chua SC, Jr., Tanowitz HB 2010 Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection. J Infect Dis 202:1104-1113

    80.       Park J, Kusminski CM, Chua SC, Scherer PE 2010 Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo. Am J Pathol 177:3133-3144

    81.       Tschop J, Nogueiras R, Haas-Lockie S, Kasten KR, Castaneda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S, Jr., Farooqi IS, O'Rahilly S, Caldwell CC, Tschop MH 2010 CNS leptin action modulates immune response and survival in sepsis. J Neurosci 30:6036-6047

    82.       Caviglia JM, Betters JL, Dapito DH, Lord CC, Sullivan S, Chua S, Yin T, Sekowski A, Mu H, Shapiro L, Brown JM, Brasaemle DL 2011 Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity. J Lipid Res 52:2032-2042

    83.       Childs GV, Akhter N, Haney A, Syed M, Odle A, Cozart M, Brodrick Z, Gaddy D, Suva LJ, Akel N, Crane C, Benes H, Charlesworth A, Luque R, Chua S, Kineman RD 2011 The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity. Endocrinology 152:69-81

    84.       Donato J, Jr., Cravo RM, Frazao R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S, Jr., Coppari R, Zigman JM, Elmquist JK, Elias CF 2011 Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest 121:355-368

    85.       Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC, Jr., Myers MG, Jr., Leibel RL, Houpt E, Gilchrist CA, Sher A, Porcella SF, Petri WA, Jr. 2011 A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest 121:1191-1198

    86.       Guo X, Roberts MR, Becker SM, Podd B, Zhang Y, Chua SC, Jr., Myers MG, Jr., Duggal P, Houpt ER, Petri WA, Jr. 2011 Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosal Immunol 4:294-303

    87.       Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua SS, Jr., Obici S, Magrisso IJ, Pan W 2011 Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. Peptides 32:1392-1399

    88.       Luo N, Marcelin G, Liu SM, Schwartz G, Chua S, Jr. 2011 Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. Endocrinology 152:883-889

    89.       Tanowitz HB, Jelicks LA, Machado FS, Esper L, Qi X, Desruisseaux MS, Chua SC, Scherer PE, Nagajyothi F 2011 Adipose tissue, diabetes and Chagas disease. Adv Parasitol 76:235-250

    90.       Vong L, Ye C, Yang Z, Choi B, Chua S, Jr., Lowell BB 2011 Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71:142-154

    91.       Akhter N, Odle AK, Allensworth-James ML, Haney AC, Syed MM, Cozart MA, Chua S, Kineman R, Childs GV 2012 Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity. Endocrinology 153:4705-4715

    92.       Blouet C, Liu SM, Jo YH, Chua S, Schwartz GJ 2012 TXNIP in Agrp Neurons Regulates Adiposity, Energy Expenditure, and Central Leptin Sensitivity. J Neurosci 32:9870-9877

    93.       Dutia R, Kim AJ, Mosharov E, Savontaus E, Chua SC, Jr., Wardlaw SL 2012 Regulation of prolactin in mice with altered hypothalamic melanocortin activity. Peptides 37:6-12

    94.       Guo M, Huang TY, Garza JC, Chua SC, Lu XY 2012 Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol 16:857-867

    95.       Guo M, Lu Y, Garza JC, Li Y, Chua SC, Zhang W, Lu B, Lu XY 2012 Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Transl Psychiatry 2:e83

    96.       Israel DD, Sheffer-Babila S, de Luca C, Jo YH, Liu SM, Xia Q, Spergel DJ, Dun SL, Dun NJ, Chua SC, Jr. 2012 Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology 153:2408-2419

    97.       Marcelin G, Liu SM, Li X, Schwartz GJ, Chua S 2012 Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice. J Lipid Res 53:964-972

    98.       McKimpson WM, Weinberger J, Czerski L, Zheng M, Crow MT, Pessin JE, Chua SC, Jr., Kitsis RN 2012 The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote beta-Cell Survival. Diabetes 62:183-193

    99.       Eerola K, Nordlund W, Virtanen S, Dickens AM, Mattila M, Ruohonen ST, Chua SC, Jr., Wardlaw SL, Savontaus M, Savontaus E 2013 Lentivirus mediated alpha-melanocyte stimulating hormone overexpression in the hypothalamus decreases diet induced obesity in mice. J Neuroendocrinol

    100.     Lu Z, Marcelin G, Bauzon F, Wang H, Fu H, Dun SL, Zhao H, Li X, Jo YH, Wardlaw S, Dun N, Chua S, Jr., Zhu L 2013 pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J 32:844-857

    101.     Marcelin G, Liu SM, Schwartz GJ, Chua SC, Jr. 2013 Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance. Diabetes 62:2784-2795

    102.     Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Jr., Barsh GS, Koliwad SK, Xu AW 2013 Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci 33:11972-11985

     

    103.     Marcelin G, Jo YH, Li XS, Schwartz G, Zhang Y, Dun NJ, Lyu RM, Blouet C, Chang JK, Chua S Jr. 2013 Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Molecular Metabolism, in press.

    104.     Sheffer-Babila S, Sun Y, Israel DD, Liu SM, Neal-Perry G, Chua SC Jr. 2013 Agouti-related peptide plays a critical role in leptin’s effects on female puberty and reproduction. American Journal of Physiology – Endocrinology and Metabolism, in press.

 

 

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