Division of Infectious Diseases

Dr. Yoram A. Puius, M.D.,  Ph.D.

Yoram A. Puius, M.D., Ph.D.

Assistant Professor, Department of Medicine (Infectious Diseases)

Professional Interests

Dr. Yoram Puius completed MD and PhD degrees at the Albert Einstein College of Medicine in 2001. His original research was in the structural biology of signal transduction proteins in the laboratory of Dr. Steven Almo. After completing a residency in Internal Medicine at New York Hospital, he completed a fellowship in Infectious Diseases at Columbia Presbyterian, before an additional year at Tufts Medical Center focusing on infections in transplant recipients.

Dr. Puius's first position was at Roger Williams Medical Center in Providence, Rhode Island in 2007. There he served as Medical Director of Infection Control and Assistant Program Director of the Internal Medicine Residency, while holding the rank of Assistant Professor at Boston University School of Medicine. In Rhode Island he further developed interest and expertise in tickborne diseases. In addition, he directed infectious diseases protocols and education for the sole Bone Marrow Transplant Unit in the state of Rhode Island. 

Since joining Einstein Montefiore in 2011 at the rank of Assistant Professor, Dr. Puius has worked closely with transplant teams providing inpatient and outpatient consultations, working on protocols for various selection committees, and developing an online transplant infections curriculum. He has also served as Associate Program Director for the Fellowship in Infectious Diseases. He remains clinically active in the evaluation and treatment of tickborne diseases.

Dr. Puius is a member of the Infectious Diseases Society of America, the American Society for Transplantation, and the Transplantation Society. He has been a reviewer for Transplant Infectious Diseases, the Cleveland Clinic Journal of Medicine, and the American Journal of Critical Care.  He publishes and speaks regionally on infections in the immunocompromised host and Lyme disease.

Clinical Interests:

- Infections in the immunocompromised host, including recipients of kidney, liver, heart, and stem cell transplants

- Infections in patients with hematological malignancies

- Infections in patients with Left Ventricular Assist Devices

- Lyme disease

- Pre-travel counseling and vaccination for the immunocompromised patient

Selected Publications

  1. Kutner, A., Aldrich, M. Patel, S. Kang, J. J., Amin, B. Mann, R., Ali I. M., Brasil Martines, R., Cope, J. R., De Boccardo, G. O., and Puius, Y.A. (2017) Acanthamoeba Endophthalmitis During Treatment for Cutaneous Disease in a Renal Transplant Patient.  Transplant Infectious Diseases, in press.
  2. Levy, D.T., Peck, N., Minamoto, G.Y., Puius, Y.A., D’Alessandro, D.A., Goldstein, D. and Muggia, V.A.  (2015)  The role of gallium SPECT-CT in the diagnosis of left ventricular assist device infections:  A case series and review of the literature.  ASAIO J., 61(1):  e5-e10.
  3. Levy, D.T., Guo, Y., Simkins, J., Puius, Y.A., Muggia, V.A., Goldstein, D.J., D'Alessandro, D.A., and Minamoto, G.Y. (2014) Left ventricular assist device exchange for persistent infection: a case series and review of the literature. Transplant Infectious Diseases16(3):453-460.
  4. Puius, Y.A., Sonder, G. B., and Mileno, M. (2013)  Chapter 27:  The Immunocompromised Traveler.  In:  Travel Medicine, 3rd Edition, Jay Keystone, Ed.  Elsevier.
  5. Irizarry-Acosta, M. and Puius, Y.A. (2010)  Post-influenza pneumonia:  Everything old is new again.  Medicine and Health in Rhode Island, 93: 204-211.
  6. Puius, Y.A. and Kalish, R.A. (2008)  Lyme Arthritis:  Pathogenesis, Clinical Presentation, and Management.  Infectious Disease Clinics of North America, 22: 289-300.
  7. Puius, Y.A., Shah, D.P., Brust, D.G., Dove, L.M., and Lefkowitch, J.H.  (2008) Three Cases of Autoimmune Hepatitis in HIV Infected Patients.  Journal of Clinical Gastroenterology, 42:  425-429.
  8. Puius, Y.A. and Snydman, D.R. (2007)  Prophylaxis and treatment of CMV disease in recipients of solid organ transplants:  Current approach and future challenges.  Current Opinion in Infectious Diseases 20:  419-424.
  9. Puius, Y.A. and Scully, B. (2007)  Treatment of Candida albicans pericarditis in a heart transplant patient.  Transplant Infectious Diseases 9:  229-232.
  10. Puius, Y.A., Stievater, T.H., and Srikrishnan, T. (2006)  Crystal structure, conformation, and absolute configuration of kanamycin A.  Carbohydrate Research 341:  2871-2875.
  11. Dewan, J.C., Feeling-Taylor, A., Puius, Y.A., Patskovska, L., Patskovsky, Y., Nagel, R.L., Almo, S.C., and Hirsch, R.E.(2002)  Structure of mutant human carbonmonoxyhemoglobin C (βE6K) at 2.0 Å resolution.  Acta Crystallographica D58:  2038-2042.
  12. Sarmiento, M., Puius, Y.A., Vetter, S.W., Keng, Y.-F., Wu, L., Zhao, Y., Lawrence, D.S., Almo, S.C., and Zhang, Z.-Y.  (2000)  Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.  Biochemistry 39:  8171-8179.
  13. Puius, Y.A., Fedorov, E.V., Eichinger, L., Schleicher, M., and Almo, S.C. (2000)  Mapping the functional surface of domain 2 in the gelsolin superfamily.  Biochemistry 39:  5322-5331.
  14. Puius, Y.A., Zou, M., Ho, N.T., Ho, C., and Almo, S.C. (1998)  Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(α96Val®Trp). Biochemistry 37:  9258-65
  15. Puius, Y.A., Mahoney, N.M., and Almo, S.C. (1998)  The modular structure of actin-regulatory proteins. Current Opinion in Cell Biology  10: 23-34.
  16. Puius, Y.A., Zhao, Y., Sullivan, M., Lawrence, D.S., Almo, S.C., and Zhang, Z.-Y. (1997)  Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.  Proceedings of the National Academy of Sciences of the U.S.A.  94: 13420-13425.

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