John M. Greally, M.B.,B.Ch., Ph.D.
Epigenomics is a term that can be used to describe two areas of research:
a. The study of epigenetic regulation of gene expression using high-throughput techniques, or
b. The study of the influence of DNA sequence on epigenetic regulation.
To do both, you need to combine molecular and bioinformatic studies, the twin technical components of this lab's research.
We apply these approaches to the study of human disease. Our specific interests include cancer, type II diabetes mellitus, ageing and environmental influences on the epigenome.
We have recently established a Center for Epigenomics at Einstein, including an Epigenomics Shared Facility and a Computational and Statistical Epigenomics Resource. Our goal is to use the technologies we develop and the insights into the normal epigenome as the foundation for understanding epigenomic dysregulation in human disease. The Center facilitates the research of multiple Einstein investigators in these areas of research.
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