Division of General Internal Medicine

James C.M. Brust, M.D.

Dr. James C.M. Brust

Assistant Professor, Department of Medicine (General Internal Medicine)


Professional Interests

Dr. Brust is an Assistant Professor in the Department of Medicine, with joint appointments in the Divisions of General Internal Medicine and Infectious Diseases. He graduated from the Columbia University College of Physicians & Surgeons and completed both a residency in Internal Medicine and a fellowship in Infectious Diseases at the Columbia University Medical Center. During his ID training, he completed the Patient-Oriented Research Scholars Program at the Mailman School of Public Health and obtained an M.S. in biostatistics. Also during his fellowship, he was awarded a research grant from Bristol-Myers Squibb for work on HIV and HBV co-infection.

Dr. Brust's research interests lie primarily in rural KwaZulu-Natal, South Africa, where, along wirth his Einstein colleagues, Drs. Neel Gandhi and Sarita Shah, he has been studying the dual epidemics of multidrug-resistant tuberculosis (MDR TB) and HIV.  He designed and implemented a novel, home-based treatment program for patients co-infected with HIV and MDR TB and was awarded a K23 Career Development grant from the NIAID to study the program.

In addition to working in international health, Dr. Brust is also interested in the management of viral hepatitis in HIV-infected patients. He is currently conducting a study of HIV/HBV treatment in the Veterans Affairs health system.

Current Investigations

  1. Integrated, home-based treatment for MDR TB and HIV in rural South Africa
  2. Early identification and empiric treatment of patients suspected of having MDR TB in Tugela Ferry, South Africa.
  3. Molecular epidemiology of multidrug- and extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa
  4. Management of HIV and Hepatitis B co-infection in US veterans.


  1. K23 Career Development Award, NIAID, NIH (2010-2015).
  2. Bristol-Myers Squibb Virology Research Fellows Award (2007-2008)
  3. Patient-Oriented Research Scholar (K30), Irving Institute for Clinical and Translational Research, Columbia University Medical Center (2006-2008).

Selected Publications

Brust JCM, Shah NS, Scott M, Chaiyachati K, Lygizos M, van der Merwe TL, Bamber S, Radebe Z, Loveday M, Moll AP, Margot B, Lalloo UG, Friedland GH, Gandhi NR. Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care. Int J Tuberc Lung Dis (in press).


Gandhi NR, Andrews JR, Brust JCM, Montreuil R, Weissman D, Heo M, Moll AP, Friedland GH, Shah NS. Risk factors for mortality among MDR- and XDR-TB patients in a high HIV-prevalence setting. Int J Tuberc Lung Dis. 2012; 16(1):90-97


Brust JCM, O’Donnell MR, and Metcalfe JZ. TB/HIV: An orphan disease? Am J Resp Crit Care Med. 2011; 183:1441-2


Brust JCM, Litwin AH, Berg KM, Li X, Heo M, and Arnsten JH. Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance. AIDS Res Hum Retroviruses. 2011; 27(5):535-41


Brust JCM, Lygizos M, Chaiyachati K, Scott, M, van der Merwe TL, Moll AP, Li X, Loveday M, Bamber S, Lalloo UG, Friedland GH, Shah NS, and Gandhi NR. Culture conversion among HIV co-infected multidrug-resistant tuberculosis patients in Tugela Ferry, South Africa. PLoS One 6(1): e15841. doi:10.1371/journal.pone.0015841


Brust JCM, Gandhi NR, Carrara H, Osburn G and Padayatchi N. High Treatment Failure and Default Rates for Patients with MDR TB in KwaZulu-Natal, South Africa, 2000-2003. Int J Tuberc Lung Dis. 2010; 14(4):413-9


Brust JCM, Whittier S, Scully BE, McGregor CC and Yin MT. Five cases of bacteremia due to Gordonia species. Journal of Medical Microbiology. 2009; 58:1376-1378


Brust JCM and Arnsten JH. Bone mineral density and fracture risk in HIV infection. Future Rheumatology. 2008; 3(6):523-6 


Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.


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