Department of Genetics

Genomics Core


The Genomics Core serves the Einstein scientific community by providing a broad scala of services, utilizing current and emerging nucleic acid technologies. Microarrays, real-time PCR, Sanger sequencing and new, massively parallel sequencing (MPS; also known as next-gen sequencing) are available. The Core provides a number of technologies for genotyping DNA from humans or model organisms, varying from SNP (single nucleotide polymorphism) detecting to sequencing DNA for unknown variations. Furthermore, the Genomics Core performs quantitative CpG methylation analysis for the Epigenomics Core.

Access Services

The Genomics core uses iLab for sample submission, device reservations and billing. Einstein and Montefiore users should log-in to the system as internal users with their active directory credentials. External customers should sign-up for an account. Please see our iLab help and support page for user guides and more information about iLab.


DNA Sequencing & Genotyping Technologies

  • Traditional DNA sequencing (ABI 3730)- tubes for single samples or 96 well plates
    • Optional PCR or plasmid purification prior to sequencing
  • MPS (Next Gen Sequencing)- Massively Parallel Sequencing
    • Illumina GAII—36+ bp reads; useful for large genomes
    • Roche 454—400+ bp reads; useful for de novo sequencing and microorganisms
  • Sequenom EpiTyper - for Quantitative Cytosine Methylation
  • Sequenom iPLEX - multiplex SNP genotyping by Single Base Extension; 1-40 SNPs/assay
  • Pyrosequencing – singleplex typing of SNPs with sequence context.
  • Fragment analysis - microsatellite markers; Multiplex Ligation-dependent Probe Amplification (MLPA) for detection of copy number and genomic disorders.

Microarry & Expression Technologies

  • Microarrays
    • Affymetrix Exon Arrays for gene expression and splice variant analysis
      • Gene 1.0 ST – new, lower cost arrays for gene expression
      • SNP 6.0 arrays: Genome-wide SNP and copy number variant typing- 1.8 M markers
    • NimbleGen – ChIP on Chip, HELP-Chip
  • Real Time qPCR (ABI 7900) 384 well and 96 well instruments
    • Quantitative gene expression,
    • HRM (High Resolution Melting) – SNP discovery
    • Copy number analysis
  • Sequenom QGE – multiplex quantitative gene expression and copy number analysis
  • Bioanalyzer - RNA and DNA Quality Analysis with Agilent Bioanalyzer 2100
    • Nanodrop – RNA and DNA quantitation

Data is made available to researchers and their PIs through the Core’s Laboratory Information Management System, GeneSifter. The data is screened with appropriate quality control measures. The Genomics Core provides file formats that are ready for analysis. Assistance with retrieving data, instructions as to how to use the tools and more extensive data analysis on a fee-for-service basis are provided by the Computational Genomics Core.

Analytical resources are available to AECOM researchers at the Analytical Tools website maintained by the Computational Genomics Core. This site includes CLC Genomics Workbench, Ingenuity Pathway Analysis, R/BioConductor and more. Additional resources for microarray analyses are available at GenePattern.


Ullmann Building, Room 1203
Deposit DNA samples in the undercounter refrigerator. Deposit RNA samples in the undercounter freezer. Both are marked “Sample Deposit.”

Samples for Traditional Sequencing may also be dropped off in one of our dropboxes, available in most buildings on campus. Please see the iLab sequencing submission form for active locations. Cold Room dropboxes are available for weekend and Holiday sample drops.


Faculty Advisor
Bernice Morrow, Ph.D.

David Reynolds

Ariana Fiallo
Wen Tran
Limin Wang
Kevin Lau 

Phone: 929.246.6735

Selected Publications

Leukemia, 2006 Apr;20(4):556-62
Endocrinology, 2006 Jul;147(7):3375-90
Immunity, 2006 Apr;24(4):393-403


Quick Links


News & Events

News | Papers Published in Developmental Cell and eLife

Hannes Buelow and members of his laboratory have had papers published in Developmental Cell and eLife. read more


News | Paper Published in Developmental Cell

Nick Baker's laboratory has published a paper in Developmental Cell. read more


News | Review on bHLH transcription factors

Review on bHLH transcription factors regulating neuronal development and neuronal diversity. read more

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