The New York City Research and Improvement Networking Group (NYC RING)

The Resveratrol Study

Design
Double-blind, placebo-controlled cross-over study

Intervention
Participants identified as having pre-diabetes (impaired glucose tolerance) will be randomized to receive resveratrol or placebo supplements for six weeks each. Participants will provide blood and urine during study visits. An optional muscle biopsy will be performed at the end of each treatment period.

Outcomes
To assess the effects of resveratrol on:
       •   mixed meal tolerance in subjects with glucose intolerance
       •   mitochondrial biogenesis
       •   fasting and post-meal endothelial function

Eligibility
       •    Adults age 50-80
       •    Impaired glucose tolerance (investigators will screen for this)
       •    In general good health

Incentives
Up to $300 for seven study visits

Participating Sites
Williamsbridge Family Practice and Castle Hill Family Practice

Principal Investigator
Jill Crandall, MD

Project Timeline
Active recruitment through April 2014

Recruitment Strategies
    1. Mailing and Phone Invitation
       •    Patients identified as pre-diabetic (lab glucose values between 5.7 and 7.0 without any diabetes diagnosis or on
            any diabetes-related medications) will be mailed a letter from medical directors at participating sites. Individuals
            interested in participating are instructed to contact study team directly

Contact information:
Claudia Lechuga, NYC RING Coordinator, clechuga@montefiore.org, 718-430-2023

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