Design
Double-blind, placebo-controlled cross-over study
Intervention
Participants identified as having pre-diabetes (impaired glucose tolerance) will be
randomized to receive resveratrol or placebo supplements for six weeks each. Participants
will provide blood and urine during study visits. An optional muscle biopsy will be performed
at the end of each treatment period.
Outcomes
To assess the effects of resveratrol on:
• mixed meal tolerance in subjects with glucose intolerance
• mitochondrial biogenesis
• fasting and post-meal endothelial function
Eligibility
• Adults age 50-80
• Impaired glucose tolerance (investigators will screen for this)
• In general good health
Incentives
Up to $300 for seven study visits
Participating Sites
Williamsbridge Family Practice and Castle Hill Family Practice
Principal Investigator
Jill Crandall, MD
Project Timeline
Active recruitment through April 2014
Recruitment Strategies
1. Mailing and Phone Invitation
• Patients identified as pre-diabetic (lab glucose values between 5.7 and 7.0 without any diabetes
diagnosis or on
any diabetes-related medications) will be mailed a letter from medical directors at
participating sites. Individuals
interested in participating are instructed to contact study team
directly
Contact information:
Claudia Lechuga, NYC RING Coordinator, clechuga@montefiore.org, 718-430-2023