Department of Cell Biology

Keisuke Ito, M.D. Ph.D -- Recent Publications


Assistant Professor
Department of Cell Biology
Price Bldg., Room 102
(718) 678-1278

Research Interest
Recent Publications
Lab Members
Dr. Ito’s faculty page

Stem Cell Institute

Selected Original research and Theoretical treatises;

1. Song, S.J.*, Ito, K.*, Ala, U., Kats, L., Webster, K., Sun, S.M., Jongen-Lavrencic, M., Manova-Todorova, K., Teruya-Feldstein, J., Avigan, D.E., et al. (2013). The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell stem cell 13, 87-101. *Contributed equally to this work.

2. Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013). Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 502, 637-643.

3. Ito, K.*, Carracedo, A.*, Weiss, D., Arai, F., Ala, U., Avigan, D.E., Schafer, Z.T., Evans, R.M., Suda, T., Lee, C.H., et al. (2012). A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nature medicine 18, 1350-1358. *Contributed equally to this work.

4. Garcia-Cao, I., Song, M.S., Hobbs, R.M., Laurent, G., Giorgi, C., de Boer, V.C., Anastasiou, D., Ito, K., Sasaki, A.T., Rameh, L., et al. (2012). Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 149, 49-62.

5. Giorgi, C., Ito, K., Lin, H.K., Santangelo, C., Wieckowski, M.R., Lebiedzinska, M., Bononi, A., Bonora, M., Duszynski, J., Bernardi, R., et al. (2010). PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 330, 1247-1251.

6. Maeda, T.*, Ito, K.*, Merghoub, T., Poliseno, L., Hobbs, R.M., Wang, G., Dong, L., Maeda, M., Dore, L.C., Zelent, A., et al. (2009). LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Developmental cell 17, 527-540. *Contributed equally to this work.

7. Ito, K., Bernardi, R., Morotti, A., Matsuoka, S., Saglio, G., Ikeda, Y., Rosenblatt, J., Avigan, D.E., Teruya-Feldstein, J., and Pandolfi, P.P. (2008). PML targeting eradicates quiescent leukaemia-initiating cells. Nature 453, 1072-1078.

8. Ito, K.*, Hirao, A.*, Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006). Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature medicine 12, 446-451.

9. Ito, K.*, Hirao, A.*, Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004). Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997-1002.

10. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G.Y., and Suda, T. (2004). Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161.

Selected Invited articles and Review articles ($; Correponding author)

1. $Ito, K., $Suda, T. (2014). Metabolic requirements in the maintenance of self-renewing stem cells. Nature Reviews Molecular Cell Biology 15, 243-256.

2. Nakahara, F., Weiss, C.N., and $Ito, K. (2014). The role of PML in hematopoietic and leukemic stem cell maintenance. International journal of hematology.

3. Weiss, C.N., and $Ito, K. (2014). DNA damage response, redox status and hematopoiesis. Blood cells, molecules & diseases 52, 8-12.

4. Ito, K., and $Ito, K. (2013). Newly Identified Roles of PML in Stem Cell Biology. Frontiers in oncology 3, 50 (1-5). 
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