Department of Cell Biology


Wenjun Guo, Ph.D -- Recent Publications



Assistant Professor
Department of Cell Biology
Price Bldg., Room 122
(718) 678-1276

Research Interest
Recent Publications
Lab Members
Stem Cell Institute

1. Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA. (2012) Slug and sox9 cooperatively determine the mammary stem cell state. Cell 148: 1015-1028.

2. Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA. (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145: 926-940.

3. Mani SA*, Guo W*, Liao MJ*, Eaton EN, Ayyanan A, Zhou A, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campell LL, Polyak K, Brisken C, Yang J, Weinberg RA. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715. (*: equal contribution.)

4. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology 26:1269-1275.

5. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature Biotechnology 26: 795-797.

6. Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA. (2007) Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Research 67: 8131-8138.

7. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126: 489-502.

8. Guo W and Giancotti FG. (2004) Integrin signaling during tumor progression. Nature Reviews Molecular Cell Biology 5: 816 –826.

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