University Chairman, Department of Cell Biology
Professor, Department of Cell Biology
Judith and Burton P. Resnick Professor
Chanin Bldg., Room 402
718.430.2169
arthur.skoultchi@einstein.yu.edu
Research Interest
Recent Publications
Biosketch
Lab Members
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Wontakal, S. N., X. Guo, C. Smith, T. MacCarthy, E. H. Bresnick, A. Bergman, M. P. Snyder, S. M. Weissman, D. Zheng and A. I. Skoultchi (2012). A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A 109(10): 3832-3837. [PDF Full Text ]
Melcer, S., H. Hezroni, E. Rand, M. Nissim-Rafinia, A. I. Skoultchi, C. L. Stewart, M. Bustin and E. Meshorer (2012). "Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation." Nat Commun 3: 910. [PDF Full Text]
Nishiyama, M., A. I. Skoultchi and K. I. Nakayama (2012). "Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway." Mol Cell Biol 32(2): 501-512. [PDF Full Text]
Maclean, J. A., A. Bettegowda, B. J. Kim, C. H. Lou, S. M. Yang, A. Bhardwaj, S. Shanker, Z. Hu, Y. Fan, S. Eckardt, K. J. McLaughlin, A. I. Skoultchi and M. F. Wilkinson (2011). "The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation." Mol Cell Biol 31(6): 1275-1287. [PDF Full Text]
Wontakal SN, Guo X, Will B, Shi M, Raha D, Mahajan MC, Weissman S, Snyder M, Steidl U, Zheng D, Skoultchi AI. (2011). A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1. PLoS Genet. 2011 Jun;7(6):e1001392. Epub 2011 Jun 9. [PDF Full Text ]
Funato, H., M. Sato, C. M. Sinton, L. Gautron, S. C. Williams, A. Skach, J. K. Elmquist, A. I. Skoultchi and M. Yanagisawa (2010). "Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep." Proc Natl Acad Sci U S A 107(42): 18155-18160. [PDF Full Text]
Eskeland, R., M. Leeb, G. R. Grimes, C. Kress, S. Boyle, D. Sproul, N. Gilbert, Y. Fan, A. I. Skoultchi, A. Wutz and W. A. Bickmore (2010). "Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination." Mol Cell38(3): 452-464. [PDF Full Text]
Papetti, M., Wontakal, S.N., Stopka, T., Skoultchi, A.I. (2010). GATA-1 directly regulates p21 gene expression during erythroid differentiation. Cell Cycle 9(10), 1972-1980. (Epub May 18, 2010). [PDF Full Text]
Burda, P., Curik, N,, Kokavec, J., Basova, P., Mikulenkova, D., Skoultchi, A.I., Zavadil, J., and Stopka, T. (2009). PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation. Mol Cancer Res. 7, 1693-1703. PMID: 1982599. [PDF Full Text]
Choe, K. S., O. Ujhelly, S. N. Wontakal, and A. I Skoultchi. 2009. PU.1 directly regulates CDK6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells. J. Biol. Chem. Epub December 2, 2009. [PDF Full Text]
Lu, X., SN Wontakal, AV Emelyanov, P. Morcillo, AY Konev, DV Fyodorov, A.I. Skoultchi. 2009. Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure. Genes Dev 23:452-465. PDF Full Text
Nishiyama, M, K., Oshikawa, Y. Tsukada, T. Nakagawa, S Iemura, T. Natsume, Y Fan, A. Kikuchi, A.I. Skoultchi, K.I. Nakayama. 2009. CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol 11:172-82.[PDF Full Text]
Giambra, V., Volpi, S., Emelyanov, A.V., Pflugh, D., Bothwell, A.L., Norio, P., Fan, Y., Ju, Z., Skoultchi, A.I., Hardy, R.R., Frezza, D., Birshtein, B.K. 2008. Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol Cell Biol 28, 6123-33. [PDF Full Text]
Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H.S., de Kretser, D., O'Bryan, M., Blewitt, M., and Whitelaw, E. (2007). Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 39, 614-622. [PDF Full Text]
Papetti, M. and Skoultchi, A.I. Reprogramming Leukemia Cells to Terminal Differentiation and Growth Arrest by RNA Interference of PU.1 Molecular Cancer Research 5, 1053-1062, October 1, 2007. doi: 10.1158/1541-7786.MCR-07-0145. [PDF Full Text ]
Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O. Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol. 2007 Sep 24;178(7):1101-8. [PDF Full Text ]
Woodcock, C.L., A.I. Skoultchi and Y. Fan (2006). Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length. Chromosome Res 14:17-25. [PDF Full Text ]
Lang, D., Lu, M.M., Huang, L., Engleka, K.A., Zhang, M., Chu, E.Y., Lipner, S., Skoultchi, A., Millar, S.E., and Epstein, J.A. (2005). Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433, 884-887. [PDF Full Text ]
Fan, Y., T. Nikitina, J. Zhao, T. Fleury, R. Bhattacharyya, E. Bouhassira, A. Stein, C. Woodcock and A.I. Skoultchi (2005). Depletion of histone H1 in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell 123(7): 1199-1212 [PDF Full Text ]
Stopka, T., D. Amanatullah, M. Papetti and A.I. Skoultchi (2005). “PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.?nbsp; Embo J., 24(21): 3712-23 [PDF Full Text ]
Yu, Y.L., Chiang, Y.J., Chen, Y.C., Papetti, M., Juo, C.G., Skoultchi, A.I., and Yen, J.J. (2005). MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. J Biol Chem 280, 29533-29542. PMID: 15967790 [PDF Full Text ]
Fan Y. and Skoultchi AI. (2004) Genetic Analysis of H1 Linker Histone Subtypes And Their Functions In Mice. Methods Enzymol. 377:85-107. [PDF Full Text ]
Choe K.S., F. Radparvar, et al. (2003). “Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1. Cancer Res 63(19): 6363-9 [PDF Full Text ]
Rekhtman N., K.S. Choe, et al. (2003) “PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol Cell Biol. 23(21): 7460-74 [PDF Full Text ]
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