Title: Postdoctoral Fellowship - Mammalian Epigenomics - Chromatin Structure and Function
NIH-funded postdoctoral fellowship available at Albert Einstein College of Medicine in the laboratory of Dr. Art Skoultchi, Resnick Professor and Chair of Cell Biology.
The goal is to understand the role of H1 linker histones and chromatin remodeling ATPases in development and gene regulation. We have prepared a unique series of knock-out mice and ES cell lines lacking H1 histones and the SNF2H chromatin remodeling factor. Our studies have revealed a role for H1 histones and SNF2H in blood cell development, DNA damage repair and apoptosis, and gene regulation, including DNA methylation and imprinting (Yang PNAS 110, 1708 (2013); Lu Science 340, 78 (2013); Maclean MCB 31, 1275 (2011); Nishiyama Nat Cell Biol. 11, 172 (2009); Murga J Cell Biol. 178, 1101 (2007); Chong Nat Genet 39, 614 (2007); Fan Cell 123, 1199 (2005); Stopka PNAS 100, 14097 (2003)).
Candidates should possess strong independent research abilities with ambitious scientific interests, self-motivation and the ability to work effectively with a team. Experience working with embryonic stem cells and mice is a plus.
The successful applicant will be offered generous salary and benefits, including university subsidized postdoctoral housing in a pleasant residential neighborhood near the medical school.
To apply, please send a CV with a brief description of research experience and career goals and a statement about how your skills and experience will allow you to make important contributions to our research, plus contact information for three references to:
Resnick Professor and Chair
Department of Cell Biology
Chanin Bldg., Room 102
Title: Postdoctoral Position in Stem Cell and Regenerative Medicine
Dr. Keisuke Ito
Department of Cell Biology
Price Bldg., Room 102
The Ito Laboratory at the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research of the Albert Einstein College of Medicine is actively seeking highly motivated postdoctoral fellows. Our research focuses on understanding the molecular mechanisms that regulate the maintenance of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs; also referred to as leukemia stem cells). Specifically, we aim to identify novel regulatory mechanisms for stem cell fate and maintenance, and in turn open new therapeutic avenues for the pharmacological manipulation of the normal and leukemic stem cell function. Projects in the laboratory is to illuminate through both genetic and pharmacological approaches the role of one such potential regulatory element, cellular metabolism and epigenetic regulation, in the cell fate decisions of self-renewing stem cells. The laboratory employs a wide range of stem cell analysis with specialized skill sets, genomic technologies as well as classical cellular and molecular biology approaches to investigate the normal stem cell biology at single cell level and the pathogenesis of specific human stem cell disorders.
Applicants must have a Ph.D., M.D. or equivalent. A strong training background in hematology, stem cell biology and/or cancer biology, molecular and cell biology is preferred. To apply, please email CV, a summary of the previous research experience and the future research interest, and the contact information of three references to the following address: firstname.lastname@example.org. Keisuke Ito, M.D., Ph.D., Assistant Professor of Cell Biology and of Medicine and Director of Scientific Resources of Stem Cell Institute, Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461.
Among the top tier of the nation's medical schools to receive NIH funding, Albert Einstein College of Medicine offers a highly interactive and stimulating academic environment for scientists in training. Additionally, candidate’s research will benefit from the highly interactive environment within the Gottesman Institute for Stem Cell and Regenerative Medicine, the Department of Developmental and Molecular Biology, and throughout the college. We are located in a pleasant residential area in the northeast corner of New York City with easy access to Manhattan and the suburbs of Westchester County. Comprehensive Benefits package will be offered. Postdoctoral campus housing may be available.