Department of Cell Biology

Carl Schildkraut, PhD -- Recent Publications


Professor, Department of Cell Biology
Chanin Bldg., Room 416

Home Page 
Fragile Genomic Loci
Genomic Instability
Initiation Of DNA Replication
Study Replication Initiation and Fork Progression
Recent Publications 
Lab Members 

   Pan X, Drosopoulos WC, Sethi L, Madireddy A, Schildkraut CL, Zhang D (2017) FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.. Proc Natl Acad Sci U S A.:E5940-E5949. PMID: 28673972.

Madireddy, A., Kosiyatrakul, S., Boisvert, R.A., Moyano, E.H., García-Rubio, M.L., Gerhardt, J.,Vuono, E.A., Owen, N., Yan, Z., Olson, S., Aguilera, A., Howlett, N., and Schildkraut, C.L. (2016). FANCD2 facilitates replication through common fragile sites. Molecular Cell. 2016; 64(2):388-404. PMID: 27768874.

Madireddy, A., Purushothaman, P., Loosbroock, C. P., Robertson, E. S., Schildkraut, C. L., Verma, S.C. (2016). G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV. Nucleic Acids Res. 44: 3675-3694 PMID: 26837574.

Drosopoulos, W. C., Kosiyatrakul, S.K. and Schildkraut, C.L. (2015). BLM helicase facilitates telomere replication during leading strand synthesis of telomeres. J. Cell Biol. 210: 191-208. PMID: 26195664.

Gerhardt, J., Tomishima, M.J., Zaninovic, N.,Colak, D., Yan, Z., Zhan, Q., Rosenwaks, Z., Jaffrey, S. R., Schildkraut, C. L.. (2014). The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells. Molecular Cell. 53: 19 – 31. PMCID: 3920742. Featured on the Journal Cover.

Murphy, A.K. M. Fitzgerald, T. Ro, Kim, J. H., Rabinowitsch, A. I., Chowdhury, D., Schildkraut, C. L., and Borowiec, J. A. (2014). Phosphorylated RPA recruits the PALB2 tumor suppressor to stalled DNA replication forks to facilitate fork recovery. J Cell Biol. 206 : 493-507 PMCID: PMC4137056.

Gerhardt, J., N. Zaninovic, Q. Zhan, Z. Rosenwaks, A. Madireddy, S. L. Nolin, N. Ersalesi, Z. Yan1, Z. Rosenwaks and C. L. Schildkraut. (2014). Cis-acting DNA sequence at a replication initiation site promotes the expansion of CGG repeats to the fragile X full mutation. J Cell Biol. 206:599-607. PMCID: PMC4151148.

Demczuk, A., M. G. Gauthier, I.Veras, S. Kosiyatrakul, C. L. Schildkraut, M. Busslinger, J.Bechhoefer and P. Norio. (2012). Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment. PLoS Biology, PLoS Biol. 2012, e1001360. Epub 2012. PMID: 22807655.

Jeong, Y., M. Rossi, L. Cermak, A. Saraf, L. Florens, M.P. Washburn, P. Sung, C.L. Schildkraut, and M. Pagano. (2013). FBH1 mediates DNA double strand breakage and apoptosis in response to DNA replication stress. J Cell Biol., 201: 141-149 PMCID: PMC3549964.

Drosopoulos, W. C., S. Kosiyatrakul, Z. Yan, S. G. Calderano, and C. L. Schildkraut. (2012). Human telomeres replicate using chromosome-specific, rather than universal, replication programs. J Cell Biol. 197: 253- 266. PMID 22508510.

Remeseiro, S., A. Cuadrado, M. Carretero, P. Martínez, W. C. Drosopoulos, M. Canamero, C. L. Schildkraut, M. A. Blasco, and A. Losada. (2012). Cohesin SA1 deficiency drives aneuploidy and tumorigenesis in mice due to impaired replication of telomeres. EMBO J 31: PMID: 22415365.

Borowiec JA, Schildkraut CL. Open sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (Igh) locus. Curr Opin Cell Biol. 2011 23:284-92. Epub (2011). PMID: 21571518.

Verma, S.C., Lu, J., Cai, Q., Kosiyatrakul, S., McDowell, M., Schildkraut, C.L. and E. S. Robertson. Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication. PLoS Pathogens (2011), e1002365. Epub (2011) Nov 3. PMID: 22072974

Schultz, S. S., Desbordes, S. C., Du, Z., Kosiyatrakul, S., Lipchina,, I., Studer, L. and Schildkraut, C. L. Single Molecule Analysis Reveals Changes in the DNA Replication Program for the POU5F1 Locus Upon hESC Differentiation. Mol. Cell. Biol., 18:4521-34. (2010). PMID: 20647538.

Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C.L., and De Lange, T., Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell, 138: 90-103. (2009). PMID: 19596237.

Desprat, R., Thierry-Mieg, D., Lailler, N., Schildkraut, C. L., Thierry-Mieg, J., and Bouhassira, E. E. Predictable Dynamic Program of Timing of DNA Replication in Human Cells. Genome Research. Genome Res. 19:2288-2299 (2009). PMID: 19767418.

Guan, Z., Hughes, C. M., Kosiyatrakul, S. T., Norio, P., Sen, R., Fiering, S., Allis, C. D Bouhassira, E. E., and Schildkraut, C. L. Decreased Replication Origin Activity in Temporal Transition Regions. Journal of Cell Biology. 187:623-35 (2009). PMID:19951913.

Norio, P., Kosiyatrakul, S.,Yang, Q., Guan, Z.,Brown, N., Thomas, S., Riblet, R., and Schildkraut, C.L. Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development. Mol. Cell 20: 575 - 587(2005). PMID: 16307921.

Yang, Q., Riblet, R., Schildkraut, C.L. Sites that Direct Nuclear Compartmentalization are Near the 5' End of the Mouse Immunoglobulin Heavy Chain Locus. Mol. Cell. Biol. 25: 6021-6030 (2005). PMID: 15988016.

Norio P, Schildkraut C.L. Plasticity of DNA replication initiation in Epstein-Barr virus episomes. PLoS Biol 2: 816 - 833. (2004). PMID: 15208711.

Norio, P., Schildkraut, C.L. Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes. Science 294: 2361-2364 (2001). PMID: 11743204.

Click here to log in