Research in the Department of Cell Biology is focused on understanding molecular mechanisms of gene regulation in eukaryotic cells. Using mammalian cells, yeast, viruses, fruit flies and transgenic mice, we are investigating mechanisms of DNA replication and repair, control of the cell cycle and apoptosis, roles for transcriptional regulation and chromatin structure in gene expression, RNA processing, intracellular trafficking, membrane fusion and budding, mechanisms of generating antibody diversity, and the functions of cell surface sugars.
In the News
Dr. Ulrich Steidl has received a prestigious Scholar Award from the Leukemia & Lymphoma Society for his work on the role of transcription and epigenetic regulation of hematopoietic and leukemic stem cells. A number of findings made by his research team also have implications for treating blood cancers including myeloid leukemias and myelodysplastic syndromes. Congratulations!
Dr. Pamela Stanley was awarded with the eighth annual Marshall S. Horwitz, M.D. Faculty Prize for Research Excellence. The prize will be awarded at a community-wide ceremony on Monday, February 3, 2014, during which Dr. Stanley will deliver a lecture, “Glycans that Regulate Development and Notch Signaling,” describing the work that led to her selection. Congratulations to Dr. Pamela Stanley.
Dr. Britta Will, a postdoctoral research fellow in the lab of Dr. Ulrich Steidl, was awarded with the 2013 annual Dennis Shields Postdocoral Research Prizes. Congratulations to Dr. Britta Will and the lab of Dr. Ulrich Steidl.
From the Stanley Lab - Yuan F, Snapp EL, Novikoff PM, Suadicani SO, Spray DC, Potvin B, Wolkoff AW, Stanley P. Human liver cell trafficking mutants: characterization and whole exome sequencing. PLoS One. 2014 Jan 23;9(1):e87043. doi: 10.1371/journal.pone.0087043. eCollection 2014.
• Liver cell mutants defective in endocytosis and trafficking were analyzed by exome sequencing. A new dominant mutation in RAB22A (I34F) contributed to the Trf4 phenotype.
From the Schildkraut Lab - Gerhardt J, Tomishima MJ, Zaninovic N, Colak D, Yan Z, Zhan Q, Rosenwaks Z, Jaffrey SR, and C.L. Schildkraut. The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Molecular Cell 53(1):19-31 (2014) PMID: 24289922.
• This study provides evidence that the DNA replication fork direction is critically involved in CGG repeat expansion, the underlying cause of fragile X syndrome.
From the Kielian Lab - Ooi, Y.S.*, K.M. Stiles*, C.Y. Liu*, G.M. Taylor, and M. Kielian. Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry. *Equal contribution. PLoS Pathogens 9 (12): e1003835. (2013) PMID: 24367265.
• Using a whole genome siRNA screen, we identified and defined the mechanism of FUZ and TSPAN9, two novel host proteins that promote alphavirus entry.
From the Ye Lab - Huang, X., Meng, B., Iqbal, J., Ding, B.B., Perry, A.M., Cao, W., Smith, L.M., Bi, C., Jiang, C., Greiner, T.C., Weisenburger, D., Rimsza, L., Rosenwald, A., Ott, G., Delabie, J., Campo, E., Braziel, R., Gascoyne, R., Cook, J., Tubbs, R., Jaffe, E., Armitage, J., Vose, J., Staudt, L., McKeithan, T.W., Chan, W., Ye, B.H.*, Fu, K*. Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma patients treated with R-CHOP. * Equal contribution. J Clin Oncol. 31(36):4520-8 (2013) PMID: 24220556.
• This study shows that STAT3 activation predicts poor survival of patients with diffuse large B cell lymphomas, adding support to STAT3-directed lymphoma therapy.
From the Stanley Lab - Miwa HE, Koba WR, Fine EJ, Giricz O, Kenny PA, Stanley P. Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. Glycobiology. 23(12):1477-90 (2013) PMID: 24037315
• The bisecting GlcNAc on complex N-glycans plays a tumor suppressive role in mouse mammary tumors and correlates with relapse-free survival in human breast cancers.