Project 1: Autophagy Dysfunction and the Stress Response in Aging
Principal Investigator: Ana Maria Cuervo, M.D., Ph.D.
Project 1 investigates the contribution of the impairment in autophagy with age to the functional deterioration and inability to orchestrate an efficient stress response in aging.
- Aging and the Stress Response
- Macroautophagy and Aging
- Molecular Basis of Proteolytic Crosstalk
- Restoration of Autophagy
More info: www.einstein.yu.edu/cuervo/_private/ppg/myweb4/project_1.htm
Cuervo Lab Website: www.einstein.yu.edu/cuervo/
Project 2: Mechanisms of Antigen Processing and Presentation in Aging Dendritic Cells
Principal Investigator: Laura Santambrogio, M.D., Ph.D.
Project 2 investigates different aspects of antigen processing and presentation during immunosenescence.
- Aging and Antigen Processing
- Autophagy and Antigen Presentation
- Spectratyping of Aging
- Characterization of Lysosomal Processing Compartments
More info: www.einstein.yu.edu/cuervo/_private/ppg/myweb4/project_2.htm
Project 3: Autophagy Dysfunction and Immunosenescence
Principal Investigator: Fernando Macian-Juan, M.D., Ph.D.
Project 3 investigates the role that autophagy plays in the control of T cell responses and determine if the decrease in autophagic activity with age isinvolved in the immunosenescent phenotype.
- Autophagy and T cell activation
- Autophagy and T cell tolerance
- Mechanisms of Immunosenescence
More info: www.einstein.yu.edu/cuervo/_private/ppg/myweb4/project_3.htm
Macian-Juan Lab Website: www.einstein.yu.edu/macian/
Project 4: Altered Cellular Response to Lipids in Aging
Principal Investigator: Mark J. Czaja, M.D.
Studies in Project 4 will examine the effect of decreased autophagy on cellular responses to free fatty acids (FFA) in aging.
- Autophagy and lipid metabolism
- Lipid accumulation and autophagy
- Aging and the metabolic syndrome
- FFA and immune cells
More info: www.einstein.yu.edu/cuervo/_private/ppg/myweb4/project_4.htm