Marion Bessin Liver Research Center

Functional Consequences of Impaired Autophagy in Aging

Contact Us

Albert Einstein College of Medicine
625 Ullmann Building
1300 Morris Park Avenue
Bronx, NY 10461

Phone: 718.430.2098



  1. Project 1: Autophagy Dysfunction and the Stress Response  in Aging 

    Principal Investigator: Ana Maria Cuervo, M.D., Ph.D.  

    Project 1 investigates the contribution of the impairment in autophagy with age to the functional  deterioration and inability to orchestrate an efficient stress response in aging.


    • Aging and the Stress Response
    • Macroautophagy and Aging
    • Molecular Basis of Proteolytic Crosstalk
    • Restoration of Autophagy

    More info: 

    Cuervo Lab Website: 

  2. Project 2: Mechanisms of Antigen Processing and Presentation in Aging Dendritic Cells 

    Principal Investigator: Laura Santambrogio, M.D., Ph.D. 

    Project 2 investigates different aspects of antigen processing and presentation during  immunosenescence.


    • Aging and Antigen Processing
    • Autophagy and Antigen Presentation
    • Spectratyping of Aging
    • Characterization of Lysosomal Processing Compartments

    More info: 

  3. Project 3: Autophagy Dysfunction and Immunosenescence 

    Principal Investigator: Fernando Macian-Juan, M.D., Ph.D. 

    Project 3 investigates the role that autophagy plays in the control of T cell responses and determine    if the decrease in autophagic activity with age isinvolved in the immunosenescent phenotype.


    • Autophagy and T cell activation
    • Autophagy and T cell tolerance
    • Mechanisms of Immunosenescence

    More info: 

    Macian-Juan Lab Website: 

  4. Project 4: Altered Cellular Response to Lipids in Aging 

    Principal Investigator: Mark J. Czaja, M.D.  

    Studies in Project 4 will examine the effect of decreased autophagy on cellular responses to free fatty acids (FFA) in aging.


    • Autophagy and lipid metabolism
    • Lipid accumulation and autophagy
    • Aging and the metabolic syndrome
    • FFA and immune cells

    More info: 

Core Services 

  1. Core A:  Administrative 

    Director:  Ana Maria Cuervo, M.D., Ph.D. 

  2. Core B:  Analytical Imaging 

    Directors:  Laura Santambrogio, M.D., Ph.D.Frank P. Malacuso, M.Sc. 

    More info: 

  3. Core C: Aging and Transgenic Animals 

    Director:  Fernando Macian-Juan, M.D., Ph.D. 

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