Comorbidities, Coinfections and Complications

A complex array of coinfections and comorbid conditions, including end-organ  dysfunction, adversely affect the clinical course of HIV.  ART significantly improves but does not eliminate the development of HIV-associated comorbidities, coinfections, and complications (CCCs) which entails clinical management of concurrent HIV-associated CCCs across the lifespan. Several ERC-CFAR investigators are focused on determining the mechanistic basis and ameliorating the impact of infections such as tuberculosis (TB), hepatitis B and C, human  papillomavirus (HPV), and sexually transmitted infections  (STIs) on HIV disease course. Increasing our understanding of the underlying mechanisms responsible for how coinfections  and comorbid conditions impact on clinical course should lead to improved treatment and prevention of HIV infection and these related  disorders.  In addition, ERC-CFAR Investigators are engaged in research relevant to other coinfections and  opportunistic infections and HIV-related cancers, neurologic and  cognitive disorders, cardiovascular disease, mental illness and  substance use, metabolic and bone abnormalities, and liver  and renal dysfunction. Listed below are NIH-funded studies by our ERC-CFAR Investigators researching strategies to address HIV-associated Comorbidities, Coinfections, and Complications.

Investigator Institution NIH Grant Title
Jacqueline Michele Achkar  Einstein R01 AI117927  Host Biomarkers For M. Tuberculosis Infection Activity in HIV-Infected Persons
Kathryn M Anastos  Einstein U01 AI035004  Women's Interagency HIV Study (WIHS-V)
Kathryn M Anastos  Einstein U01 AI096299  Central Africa International Epidemiologic Database To Evaluate AIDS
Joan Berman  Einstein R01 DA041931  Effect Of Buprenorphine On Monocytes in the Context of Neuroaids And Opioid Abuse
Joan Berman  Einstein R01 MH112391  Monocyte CNS HIV Entry & Neurodegeneration: Translational Studies In The cART Era
Joan Berman / Harris Goldstein (Mpi)  Einstein R01 DA044584  Impact Of Illicit Drugs, HIV, and ART On Neuroinflammation and BBB Disruption
Joan Berman / Harris Goldstein (Mpi)  Einstein R01 DA048609  Mechanisms of Opioid- Mediated HIV Neuropathogenesis
John S Blanchard  Einstein R01 AI060899  Bacterial N-Acetyltransferases: Resistance To Regulation
James C.M. Brust  Einstein R01 AI114304  Safety, Pharmacokinetics, and Resistance To Bedaquiline In XDR Tb and HIV
Chinazo Cunningham  Einstein R01 DA044171  Does Medical Cannabis Reduce Opioid Analgesics In HIV+ And HIV- Adults With Pain?
David B. Hanna  Einstein R21 AG060860  Machine Learning-Based Profiles Of Atherosclerosis To Predict Disease Outcomes In Older HIV-Infected Women and Men
William R. Jacobs  Einstein R01 AI026170  Molecular Genetic Analysis of Mycobacterium Tuberculosis
Michelle H. Larsen  Einstein R01 AI114900  Novel Reporter Phages To Detect Complex Tb Drug Resistance and Persistence
Brianna Norton  Einstein K23 DA039060  Adaptation and Testing of A Primary Care HCV Group Medical Treatment Intervention
Liise-anne Pirofsky Einstein R01AG045044 Effects of Aging and HIV Infection On The Response To Pneumococcal Vaccine
Liise-Anne Pirofsky Einstein R01AI143453 Antibodies, B Cells and Resistance To Human Cryptococcosis
Qibin Qi  Einstein K01 HL129892  HIV Infection, Metabolites and Subclinical Atherosclerosis
Qibin Qi  Einstein R01 HL140976  Integrated Analysis Of CVD Risk In HIV: Gut Microbiota, Immune Function and Metabolites
Michael J. Ross  Einstein R01 DK108346  The Role Of Apol1 Polymorphisms In Promoting HIV-Related Kidney Injury
Michael J. Ross  Einstein R01 DK101338  Novel Mechanisms of Antiretroviral Protection Against HIV-Related Kidney Diseases
Anjali Sharma  Einstein R21 AG059505  Acute Effects Of Cannabis On Cognition and Mobility In Older HIV-Infected and Uninfected Women
Jonathan Shuter  Einstein R01 CA192954  Rct of an Internet Cessation Program Plus Online Social Network For HIV + Smokers
Joanna L. Starrels  Einstein K24 DA046309  Mentoring Junior Investigators To Tackle The Opioid Epidemic
Joanna L. Starrels  Einstein R01 DA039046  Prescription Opioid Use, Misuse, Disorders and HIV Outcomes
Howard D. Strickler  Einstein R01 CA230331  Next Generation of HPV and Cervical Cancer Research In HIV+ Women