Einstein-Rockefeller-CUNY Center for AIDS Research

Clinical, Translational and Implementation Science Core

The overarching goal of the ERC-CFAR’s Clinical, Translational and Implementation Science Core (CTISC) is to provide a regional research platform to support the initiation and expansion of HIV-related clinical, translational and implementation research. The CTISC will assist researchers in participant recruitment for both clinical trials (e.g. eradication research or pathogenesis) and for observational studies by active recruitment of patients with rare phenotypes (e.g. elite or viremic controllers) for studies anywhere in the United States. It also provides support for research projects assessing policy, contextual, clinic/practice and individual factors impacting uptake and outcomes of delivered services, and access to and analysis of data from three databases.

The CTISC provides access to three robust clinical databases. The HIV Clinical Cohort, from the Montefiore/Einstein clinical services, contains demographic, clinical and laboratory data on over 18,000 HIV-infected and 350,000 HIV-negative patients. This dynamic, comprehensive, longitudinal database accesses Montefiore’s extensive clinical infrastructure to facilitate enrollment of well-characterized patients (including HIV-negative controls) into new research protocols. The Amida Care Cohort leverages the informatics resources of Amida Care, the largest Medicaid Special Needs Plan in NYS, with >6,000 PLWH in NYC. The Master Research Cohort has centralized data and specimen information from ~4700 participants in 31 funded research studies. With seed funding from Einstein, these three resources have stimulated many new clinical, implementation and translational investigations within Einstein, with the primary partners (Rockefeller and CUNY) and with other investigators in NYC and nationally. The maintenance of the HIV Clinical Cohort Database succeeds through collaboration with Einstein’s Institute for Clinical and Translational Research (ICTR), an NIH-funded site in the Clinical and Translational Science Awards (CTSA) program, and its integration into the ICTR’s Informatics Commons. CTISC maintains an infrastructure to facilitate recruitment and enrollment from all three cohorts into clinical trials, observational and translational studies requiring new specimens or special studies (e.g. functional MRI) in HIV-infected individuals with specified clinical characteristics.

  • Provide a clinical research platform to serve basic, clinical/epidemiologic, translational, behavioral and implementation science investigators in New York City or beyond.
    • Leverage our large patient population (18,000 PLWH, representing 150,000 person-years) seen since 1997 to catalyze new research and recruit participants for investigators conducting clinical trials or other studies.
    • Use state-of-the-art informatics provided through Einstein’s ICTR to maintain databases derived from Montefiore/Einstein’s integrated electronic health informatics system and Amida Care to support new investigations in diverse, underrepresented groups (e.g. women, pregnancy, MSM of color, HIV-exposed) through support in study design, biostatistics, database access and specimen collection.
    • Integrate with the ERC-CFAR’s Behavioral Science Core and the Scientific Working Groups (Eradication, Patient and Population Health Outcomes Research) to support the entire ERC-CFAR’s scientific goals.
     
  • Advance collaboration under the umbrella of implementation science
    • Support research to identify multi-level factors that influence timely and sustained achievement of HIV Care/Prevention Continuum outcomes (e.g. uptake of PrEP, early diagnosis, sustained viral suppression) in specific populations.
     
  • Support bench scientists in translational investigation (e.g. virologic, immunologic, genetic) studies
    • Provide human specimens, both through the existing research and clinical biorepositories (Master Research Cohort), and through rapidly sourcing, enrolling and consenting patients with specific characteristics, assisting in IRB approval, and supporting fresh specimen collection, transport and processing.
     
  • For further information, please contact our study coordinator, Ms. Madeline Torres, at ctisc-admin@einstein.yu.edu. 

Dr. Kathy Anastos
Director, ERC Clinical Translational and Implementation Science Core, Einstein
Professor, Medicine, Epidemiology & Population Health, Obstetrics & Gynecology and Women's Health
Co-Director, Global Health Center  

Dr. Marina Caskey
Associate Director, Clinical Research Studies
Assistant Professor, Clinical Investigation, Rockefeller
Member, Laboratory of Molecular Immunology

 

Dr. Howard Strickler
Associate Director, Epidemiologic Studies
Professor, Epidemiology & Population Health, Einstein
Harold and Muriel Block Chair, Epidemiology & Population Health
Division Head, Div of Epidemiology

Dr. Heidi Jones
Associate Director, Implementation Science
Associate Professor, Epidemiology, CUNY School of Public Health

 

Dr. Uriel Felsen
Assistant Professor, Medicine (Infectious Diseases), Einstein 

Ms. Mindy Ginsberg
Senior Associate, Epidemiology & Population Health, Einstein
Director, Epidemiology, Informatics and Study Management Unit

 

Dr. David Hanna
Research Assistant Professor, Epidemiology & Population Health, Einstein 

Ms. Madeline Torres
Research Nurse and Study Coordinator, ERC Clinical Translational and Implementation Science Core, Einstein 

 

HIV Clinical Cohort Database

The HIV Clinical Cohort Database is an epidemiologic resource containing de-identified demographic, clinical, laboratory, prescription, and outcomes data on over 18,000 HIV-infected and 350,000 HIV-negative patients seen in the Montefiore Health System since 1997.

This dynamic, comprehensive, longitudinal database based on Montefiore’s extensive clinical infrastructure, including the Epic electronic medical record, serves two purposes:

  1. To facilitate the development of epidemiologic studies, including those focused on implementation science
  2. To serve as potential source of study participants for clinical studies.

Data cleaning and other quality assurance activities are conducted on datasets that are generated twice each year, with a focus on key HIV-related variables. Data dictionaries summarize the major variables that are maintained in the database. The database is managed by the Epidemiology Informatics and Study Management Unit (EISMU) of Albert Einstein College of Medicine, and all study activities are managed by the CTISC.

To propose a project utilizing the HIV Clinical Cohort Database, please complete the Collaboration Concept Sheet Submission Form. Please direct all inquiries to the study coordinator at ctisc-admin@einstein.yu.edu.

 

Recent publications supported by the Clinical, Translational and Implementation Science Core

  • Bien CH, Patel VV, Blackstock OJ, Felsen UR (2017).  Reaching key populations: PrEP uptake in an urban health care system in the Bronx, New York.  AIDS Behav 5: 1309-1314.  Pubmed 
  • Dara JS, Hanna DB, Anastos K, Wright R, Herold BS (2018).  Low birth weight in human immunodeficiency virus-exposed uninfected infants in Bronx, New York.  J Ped Infect Dis Soc, ePub 30 Dec 2017.  Pubmed 
  • Felsen UR, Bellin EY, Cunningham CO, Zingman BS (2014).  Development of an electronic medical record-based algorithm to identify patients with unknown HIV status.  AIDS Care 26: 1318-1325.  Pubmed 
  • Hanna DB, Felsen UR, Ginsberg MS, Zingman BS, Beil RS, Futterman DC, Strickler HD, Anastos K (2016).  Increased antiretroviral therapy use and virologic suppression in the Bronx in the context of multiple HIV prevention strategies.  AIDS Res Hum Retroviruses 32: 955-963.  Pubmed 
  • Kuniholm MH, Leach T, Lunievicz J, Olivo N, Anastos K, Vazquez Y, Brennan-Ing M, Karpiak SE, Alao O, Nash D, Ernst J (2015).  Hepatitis C direct acting antiviral therapies in a New York City HIV/AIDS Special Needs Plan: Uptake and barriers.  AIDS Pt Care STDs 29: 643-645.  Pubmed 
  • Ross J, Cunningham CO, Hanna DB (2017).  HIV outcomes among migrants living in high-income countries: a review of recent evidence. Curr Opin Inf Diseases, ePub 1 Nov 2017.  Pubmed 
  • Ross J, Felsen UR, Cunningham CO, Patel VV, Hanna DB (2017).  Outcomes along the HIV care continuum among undocumented immigrants in clinical care.  AIDS Res Hum Retroviruses 33: 1038-1044.  Pubmed 
  • Ross J, Hanna DB, Felsen UR, Cunningham CO, Patel VV (2017).  Emerging from the database shadows: Characterizing undocumented immigrants in a large cohort of HIV-infected persons.  AIDS Care 12: 1491-1498.  Pubmed 
  • Shitole SG, Kayo N, Srinivas V, Alapati V, Nordin C, Southern W, Christia P, Faillace RT, Scheuer J, Kizer JR (2016).  Clinical profile, acute care, and middle-term outcomes of cocaine-associated ST-segment elevation myocardial infarction in an inner-city community.  Am J Cardiol 117: 1224-1230.  Pubmed 
 

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ERC-CFAR at a Glance

Partner Institutions 

  • Albert Einstein College of Medicine
  • Rockefeller University
  • The City University of New York (CUNY)
 

Investigators 

Total ERC-CFAR members

  • 183 Full members
  • 10 Affiliate members

CFAR member trainees funded by NIH K awards

  • 15 Full members
 

NIH Funding 

FY2015 OAR NIH AIDS FRB grants

$34,084,840 Total costs

 

New NIH AIDS grants awarded in FY2016

$7,345,645 Total annual costs

 

FY2014 non-AIDS NIH grants

$34,745,334 Total costs

Publications (first 6 months of 2016) 

Total Publications: 240

Publications multi-authored
by ERC-CFAR members: 91

Cores 

Administrative 

Director: Dr. H. Goldstein

 

Developmental 

Directors: Dr. V. Prasad & Dr. C. Cunningham

 

Biomarkers & Advanced Technologies 

Directors: Dr. J. Berman & Dr. S. Almo

 

Behavioral Science 

Director: Dr. L. Bauman

 

Clinical Translational Implementation Science 

Director: Dr. K. Anastos

 

Scientific Working Groups 

HIV and Eradication 

Directors: Dr. G. Kalpana & Dr. M. Caskey

 

Patient and Population Health Outcomes Research 

Directors: Dr. D. Nash & Dr. J. Arnsten  

New 2016 NIH Grants Awards 

 
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In the Media

Vice interviews Harris Goldstein, M.D., about the difficulty of developing a vaccine for HIV. Dr. Goldstein is professor of pediatrics and of microbiology & immunology at Einstein and director of the Einstein-Rockefeller-CUNY Center for AIDS Research. (Wednesday, Aug 30, 2017)

Crain’s Health Pulse interviews Dr. Laurie Bauman regarding a collaborative study aimed at controlling the spread of HIV using PrEP, a drug proven to reduce risk. Dr. Bauman is a principal investigator on the study, which includes Einstein, Montefiore and Columbia. She also is director of the Preventive Intervention Research Center and professor of pediatrics. (Friday, Jul 29, 2016)

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