Einstein-Mount Sinai Diabetes Research Center

Center for Epigenomics

Location: 3rd Floor Price Center

Director: John Greally, MB, BcH, PhD  

The Einstein Center for Epigenomics fosters multidisciplinary epigenomics research into human disease by assisting investigators in performing specialized epigenomics assays and comprehensive data analyses of these large datasets. The Epigenomics Core, along with the Animal Physiology and Stable Isotope & Metabolomics cores, provides the unique ability to perform detailed phenotyping in humans and rodent models that can be used to directly assess the causality of epigenetic alterations on metabolism.


  1. Make available to investigators specialized high-throughput molecular technological resources including microarray and massively-parallel sequencing platforms to study DNA methylation and chromatin organization
  2. Provide extensive quality controls and assurance information for all high-throughput assays, generated as part of each analysis
  3. Provide readily available dedicated systems administrators and programmers, relational database services, high-performance computing resources and data storage/backup systems through the Computational and Statistical Epigenomics Resource and Research Informatics SubCores
  4. Advise investigators regarding the best experimental platforms and protocols to use for the specific biological question being asked
  5. Disseminate current and new technological development information and foster investigator interactions through weekly workshops and journal clubs
  6. Provide laboratory training of students, postdoctoral fellows, investigators and technical staff in performing epigenomics methodologies and data analyses


  1. Analysis of epigenomic modifications within a given gene locus.
  2. Microarray and massively-parallel sequencing platforms for high-throughput epigenomic assays.
  3. High-performance computing and statistical resources.
  4. Resource training and facilitation of interactions with other laboratory and genomic services.




Illumina GAII 


Single end read (72 bp)


Paired end read (72 bp)


Roche FLX 


2 regions


4 regions


8 regions


16 regions


NimbleGen Microarray – 385K platform 


1-plex sequence capture


2 color/sample fluorescence


4 regions x 72K features/region

2 color/sample fluorescence


NimbleGen Microarray – H2D platform
(2.1 million features) 


1-plex sequence capture


2 color/sample fluorescence


3 regions x 720K features/region
2 color/sample fluorescence


12 regions x 135K features/region
2 color/sample fluorescence


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